DOI: http://dx.doi.org/10.18203/2349-2902.isj20194067

A study to determine the incidence of carcinoma of the thyroid gland in patients treated for multinodular goiter

Vikram Yogish, Challa Teja, Himanshi Grover

Abstract


Background: In the population today, the presence of multi nodular goiter (MNG) is found in quite a few people and this may be due to various reasons. The patients should be thoroughly evaluated and a detailed history must be collected. Surgical treatment is offered to patients for various reasons. The objective of this research article is, to determine the incidence and the type of carcinoma of the thyroid gland in patients treated for multinodular goiter.

Methods: A total of 105 patients who had multinodular goiter were studied. The study was carried out at SRM Medical College Hospital and Research Center, Kattankulathur, Tamil Nadu, India, from March 2016 to February 2019, for a period of three years. A detailed history was obtained and a thorough clinical evaluation was done. Investigations such as, complete blood count, thyroid function tests, ultrasound of the neck, and fine needle aspiration cytology were done. The patients then underwent total thyroidectomy and the operated specimens were subjected to histopathological examination (HPE). Out of the total of 105 patients that were studied, 21 patients were found to have carcinoma of the thyroid gland. The statistics were analysed using SPSS package 16.0.

Results: From the results it was seen that papillary carcinoma of the thyroid gland was most commonly found in the operated specimens. The findings were compared with other studies.

Conclusions: In patients with multinodulargoiter, a thorough evaluation and a detailed histopathological examination of the operated specimens must be done.


Keywords


Multinodular goiter, Histopathological examination, Fine needle aspiration cytology, Thyroid function tests, Total thyroidectomy

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References


Pelizzo MR, Piotto A, Rubello D, Casara D, Fassina A, Busnardo B. High prevalence of occult papillary thyroid carcinoma in a surgical series for benign thyroid diseases. Tumori. 1990;76:255.

Jun P, Chow LC, Jeffrey RB. The sonographic features of papillary thyroid carcinomas: pictorial essay. Ultrasonud Q. 2005;21:39-45.

Meller J, Becker W. The continuing importance of thyroid scintigraphy in the era of high resolution ultrasound. Eur J Nucl Med Mol Imag. 2002;29:S425-38.

Caragacianu D, Pakdaman MN, Kamani D, Randolph GW.Clinical characteristics of lymph node metastases in papillary thyroid carcinoma. J Am Coll Surgeons. 2014;219(4):e84–e85.

Hamburger JI. Fine needle biopsy diagnosis of thyroid nodules. Perspec Thyroidol. 1988;1:21-34.

Bloch M. Fine needle aspiration biopsy of head & neck masses. Otolaryngol Head Neck Surg. 1997;89:62–8.

Hanumanthappa MB, Gopinathan S, Rithin S, Rai GD, Shetty G, Shetty A, et al. The incidence of malignancy in multi-nodular goitre: a prospective study at a tertiary academic centre. J Clin Diag Res. 2012;6(2):267-70.

Davies L, Ouellette M, Hunter M, Welch HG. The increasing incidence of small thyroid cancers: where are the cases coming from? Laryngoscope. 2010;120:2446-51.

Schlesinger MJ, Gargill SL, Saxe IH. Studies in nodular goiter: Incidence of thyroid nodules in routine necropsies in nongoitrous region. JAMA. 1938;110:1638.

Kapur MM, Sarin R, Karmakar MG, Sarda AK. Solitary thyroid nodule. Ind J Surg. 1982;44:174–9.

Bhansali SK. Solitary nodule in the thyroid gland; experience with 600 cases. Ind J Surg. 1982;44:547–61.

Abu-Eshy SA, Khan AR, Khan GM, al-Humaidi MA, al-Shehri MY, Malatani TS. Thyroid malignancy in multinodular goitre and solitary nodule. J R Coll Surg Edinb. 1995;40:310–2.

Mofti AB, Al Momen AA, Suleiman SI, Jain GC, Assaf HM. Experience with thyroid surgery in Security Forces hospital. Riyadh Saudi Med J. 1991;12:504-6.

Stoffer RP, Welch JW, Hellwig CA, Chesky VE, McCusker EN. Nodular goiter. Incidence, morphology before and after iodine prophylaxis, and clinical diagnosis. AMA Arch Intern Med. 1960;106:10-4.

Benzarti S, Miled I, Bassoumi T, Ben Mrad B, Akkari K, Bacha O, et al. Thyroid surgery (356cases), risks and complications. Rev Laryngol Otol Rhinol (Board). 2002;123(1):33-7.

Cerci C, Cerci SS, Eroglu O, Dede M, Kopucuoglu N, Yildiz M. Thyroid cancer in toxic andnontoxicmultinodular goiter. J Postgrad Med. 2007;53:157-60.

Prades JM, Dumollard JM, Timoshenko A, Chelikh L, Michel F, Estour B, et al. Multinodular goiter, surgical management and histopathological findings. Eur Arch Otolaryngol. 2002;259:217–21.

Shah SH, Muzaffar S, Soomro IN, Hassan S. Morphological patterns and frequency of thyroid tumors. J Pak Med Assoc. 1999;49(6):131-3.