Benign inflammatory myofibroblastic tumour of the nose: a rare case report

Surya Rao Rao Venkata Mahipathy, Alagar Raja Durairaj, Narayanamurthy Sundaramurthy, Manimaran Ramachandran, Praveen Ganesh Natarajan, Vimal Chander Rajamanohar


Inflammatory myofibroblastic tumor (IMT) of the head and neck region are rare and benign and of unknown etiology. They mimic as malignant lesions both clinically and radiologically. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. Recently, the concept of this lesion being reactive has been challenged based on the clinical demonstration of recurrences and metastasis and cytogenetic evidence of acquired clonal chromosomal abnormalities. Here we report a case of a 16 year old male who presented with a swelling on the nasal dorsum for 6 months. MRI and FNAC revealed a spindle cell neoplasm. The swelling was resected completely under general anaesthesia. Histopathology with immunohistochemistry proved it to be a benign inflammatory myofibrobalstic tumour.  Complete surgical resection is the best treatment modality for IMT.


Benign, Rare, Spindle cells, Surgical excision

Full Text:



Poh CF, Priddy RW, Dahlman DM. Intramandibular inflammatory myofibroblastic tumour: A true neoplasm or reactive lesion? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(4):460-6.

Volker HU, Scheich M, Holler S, Strobel P, Hagen R, Hermenlink HK et al. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumour: Report of two cases with similar morphology. Diagn Pathol. 2007;2:1–7.

Ong HS, Ji T, Zhang CP, Li J, Wang L.Z, Li RR. Head and neck inflammatory myofibroblastic tumor (IMT): evaluation of clinicopathologic and prognostic features. Oral Oncol. 2012;48:141–8.

Margaret S, Silloo BK, Gnepp DR. Nonsquamous pathology of the larynx, hypopharynx and trachea. In: Gnepp DR, editor. Diagnostic surgical pathology of the head and neck. 4th ed. New York: W.B. Saunders Company; 2001: 287–288.

Xavier FC, Rocha AC, Sugaya NN, dos Santos-Pinto D, de Sousa SC. Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor. Medicina Oral, Patologia Oral Y Cirugia Bucal. 2009;14(12):e635-9.

Oh JM, Yim JH, Joon BW, Choi BJ, Lee DW, Kwon YD. Inflammatory pseudotumour in the mandible. J Craniofac Surg. 2008;19(6):1552-3.

Kujima M, Nakamura S, Itoh H, Suchi T, Masawa N. Inflammatory pseudoumour of the submandibular gland: Report of a case presenting with autoimmune disease like manifestation. Arch Pathol Lab Med. 2001;125(8):1095-7.

Montgomery E, Speight PM, Fisher C. Myofibromas presenting in the oral cavity: A series of 9 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(3):343-8.

Al-Sindi KA, Al-Shehabi MH, Al-Khalifa SA. Inflammatory myofibroblastic tumour of paranasal sinuses. Saudi Med J. 2007;28:623–7.

J. M. Coindre. Histologic classification of soft tissue tumors (WHO, 1994). Annales de Pathologie. 1994;14(6):426-7.

Binmadi Nada O, Packman Harold, Papadimitriou John C, Scheper Mark. Oral inflammatory myofibroblastic tumor: case report and review of literature. Open Dent J. 2011;5:66–70.

Dayan D, Nasrallah V, Vered M. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity: I. Nodular fasciitis. J Oral Pathol Med. 2005;34(7):426-35.

Brooks JK, Nikitakis NG, Frankel BF, Papadimitriou JC, Sauk JJ. Oral inflammatory myofibroblastic tumor demonstrating ALK, p53, MDM2, CDK4, pRb, and Ki-67 immunoreactivity in an elderly patient. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2005;99(6):716-26.

Coffin CM, Fletcher JA. Inflammatory myofibroblastic tumour: World Health Organization classification of tumours in Pathology and Genetics of Tumours of Soft Tissue and Bone. Fletcher CDM, Unni KK, Mertens FF, Eds., France, Lyon: IARC Press; 2002.

Sangeeta Palaskar, Supriya Koshti, Mahesh Maralingannavar, Anirudha Bartake. Inflammatory myofibroblastic tumor. Contemp Clin Dent. 2011;2(4):274–7.

Lorena Gallego, Tania R. Santamarta, Verónica Blanco, Luis García-Consuegra, Tommaso Cutilli, et al. Inflammatory Myofibroblastic Tumor of the Lung and the Maxillary Region: A Benign Lesion with Aggressive Behavior. Case Reports in Dentistry. 2013;2013:879792.