Email this article Primary hepatic lymphoma mimicking hepatocellular carcinoma: case report and review of literature
Abstract
Primary hepatic lymphoma (PHL) is a very rare malignancy presenting with non specific symptoms leading to late diagnosis. Due to its ability to masquerade other liver tumors, misdiagnosis is common. Here we present a case of a 52 years old man who presented with an incidentally detected SOL in liver with features of atypical hepatocellular carcinoma on imaging and fine needle aspiration cytology. He underwent a left hepatectomy and the final histology was a surprise in the form of hepatic lymphoma. He underwent appropriate chemotherapy post surgery and is asymptomatic at follow up.
Keywords
Full Text:
PDFReferences
Loddenkemper C, Longerich T. Lymphoma of the liver. Cavalli F, Stein H, Zucca E, eds. Extranodal Lymphomas, Pathology and Management. Abingdon, UK: CRC Press; 2008: 277-288.
Noronha V, Shafi NQ, Obando JA, Kummar S. Primary non-Hodgkin’s lymphoma of the liver. Crit Rev Oncol Hematol. 2005;53:199-207.
Emile JF, Azoulay D, Gornet JM, Lopes G, Delvart V, Samuel D, et al. Primary non-Hodgkin's lymphomas of the liver with nodular and diffuse infiltration patterns have different prognoses. Ann Oncol. 2001;1;12(7):1005-10.
Page RD, Romaguera JE, Osborne B, Medeiros LJ, Rodriguez J, North L, et al. Primary hepatic lymphoma: favorable outcome after combination chemotherapy. Cancer. 2001;92:2023-9.
Ata AA, Kamel IA. Primary reticulum cell sarcoma of the liver. A case report. J Egypt Med Assoc. 1965;48:514-21.
El-Sharkawi D, Ramsay A, Cwynarski K, Hughes D, Prentice A, Davies N, et al. Clinico-pathologic characteristics of patients with hepatic lymphoma diagnosed using image-guided liver biopsy techniques. Leuk Lymphoma. 2011;52:2130-4.
Lei KI. Primary non-Hodgkins lymphoma of the liver. Leuk Lymphoma. 1998;29:293-9.
Noronha V, Shafi NQ, Obando JA, Kummar S. Primary non-Hodgkin’s lymphoma of the liver. Crit Rev Oncol Hematol. 2005;53:199-207.
Avlonitis VS, Linos D. Primary hepatic lymphoma: a review. Eur J Surg. 1999;165:725-9.
Lisker-Melman M, Pittaluga S, Pluda JM, Kleiner DE, Thompson P, Martin P, et al. Primary lymphoma of the liver in a patient with acquired immune deficiency syndrome and chronic hepatitis B. Am J Gastroenterol. 1989;84(11):1.
Mohan C, Alurkar SS, Sharma OP, Advani SH. Primary liver lymphoma: a diagnostic dilemma. AJR Am J Roentgenol 1991;157:413.
Mohamed M, Fernando R. Diagnostic and therapeutic quandaries in a patient with primary hepatic lymphoma and concurrent hepatitis C infection. Indian J Hematol Blood Transfus 2014;30:394-7.
Sekiguchi Y, Yoshikawa H, Shimada A, Imai H, Wakabayashi M, Sugimoto K, et al. Primary hepatic circumscribed Burkitt's lymphoma that developed after acute hepatitis B: report of a case with a review of the literature. Journal of Clinical and Experimental Hematopathology. 2013;53(2):167-73.
Somaglino C, Pramaggiore P, Polastri R. Primary hepatic lymphoma in a patient with chronic hepatitis B and C infection: diagnostic pitfalls and therapeutic challenge. Updates Surg 2014;66:89-90.
Avlonitis VS, Linos D. Primary hepatic lymphoma: a review. Eur J Surg. 1999;165:725-9.
Gomyo H, Kagami Y, Kato H, Kawase T, Ohshiro A, Oyama T, et al. Primary hepatic follicular lymphoma: a case report and discussion of chemotherapy and favorable outcomes. Journal of Clinical and Experimental Hematopathology. 2007;47(2):73-7.
Scoazec JY, Degott C, Brousse N, Barge J, Molas G, Potet F, et al. Non‐Hodgkin's lymphoma presenting as a primary tumor of the liver: Presentation, diagnosis and outcome in eight patients. Hepatology. 1991;13(5):870-5.
Chowla A, Malhi-Chowla N, Chidambaram A, Surick B. Primary hepatic lymphoma in hepatitis C: case report and review of the literature. Am Surg. 1999;65:881-3.
Steller EJ, van Leeuwen MS, van Hillegersberg R, Schipper ME, Rinkes IH, Molenaar IQ. Primary lymphoma of the liver-A complex diagnosis. World J Radiol. 2012;4(2):53.
De Jong D, Xie W, Rosenwald A, Chhanabhai M, Gaulard P, Klapper W, et al. Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications: a study from the Lunenburg Lymphoma Biomarker Consortium. J Clin Oncol. 2007;25(7):805-12.
