Clinicopathological evaluation of acute appendicitis and the role of ultrasound in diagnosis: a prospective study
DOI:
https://doi.org/10.18203/2349-2902.isj20191560Keywords:
Acute appendicitis, Alvarado scoring system, UltrasoundAbstract
Background: Acute appendicitis is the most common acute surgical condition of the abdomen. Delay in treatment of acute appendicitis causes lot of complication. Study was done with the objective to study the clinical and pathological presentations of acute appendicitis, to evaluate the role of ultrasound in early diagnosis of acute appendicitis and to reduce negative appendicectomy in patients.
Methods: This is a prospective study done on 100 patients with acute right lower abdominal pain clinically presumed to be of appendicular origin. A thorough history, clinical examination and ultrasound scan, was done for all cases. All ultrasound positive cases were subjected to surgery and some negative cases were also taken for surgery based on clinical suspicion. The ultrasound diagnosis was compared with clinical findings, operative findings and histopathological examination reports.
Results: The overall accuracy of clinical diagnosis (Alvarado scoring system) with histopathology findings was 72%. The overall sensitivity and specificity was 70.3% and 81.3% respectively and positive predictive value of was 95.2% whereas the negative predictive value was 34.2%. The overall accuracy of ultrasound with histopathology report was 93%, with a sensitivity of 96.4%, specificity of 75%, and a positive predictive value of 95% and a negative predictive value of 80%. Negative appendicectomy rate was 8.82% in females and 3.63% in males.
Conclusions: The Alvarado scoring system combined with ultrasound can therefore be used as a cheap and inexpensive way of confirming acute appendicitis thus reducing negative appendicectomy rate.
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References
Stephens PL, Mazzucco JJ. Comparison of ultrasound and the Alvarado score for the diagnosis of acute appendicitis. Conn Med. 1999;63(3):137-40.
Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990;132:910‐25.
Blomqvist PG, Andersson RE, Granath F, Lambe MP, Ekbom AR. Mortality after appendectomy in Sweden. Ann Surg. 2001;233:455‐60.
Lee SL, Walsh AJ, Ho HS. Computed Tomography and Ultrasonography Do Not Improve and May Delay the Diagnosis and Treatment of Acute Appendicitis. Arch Surg. 2001;136(5):556-62.
Bondi M, Miller R, Zbar A, Hazan Y, Appelman Z, Caspi B, et al. Improving the diagnostic accuracy of ultrasonography in suspected acute appendicitis by the combined transabdominal and transvaginal approach. Am Surg. 2012;78:98‐103.
Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986;15:557‐64.
Kalan M, Talbot D, Cunliffe WJ, Rich AJ. Evaluation of the modified Alvarado score in the diagnosis of acute appendicitis: a prospective study. Ann R Coll Surg Engl. 1994;76(6):418-9.
OwenTD, Williams H, Stiff G, Jenkinson LR, Rees BI. Evaluation of the Alvarado scorein acute appendicitis. J R Soc Med. 1992;85(2):87-8.
George MJ, Siba PP, Charan PK, Rao RRM. Evaluation of Ultrasonographyas a Useful Diagnostic Aid in Appendicitis. IJS Surg. 2002;64:436–9.
Hoffmann J, Rasmussen OO. Aids in the diagnosis of acute appendicitis. Br JSurg. 1989;76(8):774-9.
Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock RE. In: Schwartz’s Principles of Surgery. 8th ed. McGraw-Hill Companies Inc; 2005: 1119-1135.
Bhattacharjee PK, Chowdhury T, Roy D. Prospective evaluation of modified Alvarado score for diagnosis of acute appendicitis. J Indian Med Assoc. 2002;100(5):310-1.
Puylaert JB. Acute appendicitis: US evaluation using graded compression. Radiology. 1986;158(2):355-60.
John H, Neff U, Kelemen M. Appendicitis diagnosis today: clinical and ultrasonic deductions. World J Surg. 1993;17(2):243-9.
Jeffrey RB Jr, Laing FC, Lewis FR. Acute appendicitis: high-resolution real-time US findings. Radiology. 1987;163(1):11-4.
Crnogorac S, Lovrenski J. Validation of the Alvarado score in the diagnosis of acute appendicitis. Med Pregl. 2001;54(11-12):557-61.
Subash KC, De A, Pathak M, Sathian B. Diagnostic Role of Ultrasonography in Acute Appendicitis: A Study at a Tertiary Care Hospital. American J Public Health Res. 2015;3(5):23-8.
Korner H, Sondenaa K, SoreideJa, Andersen E, Nysted A, Lende TH, et al. The study of negative appendicectomyrates in Male and Female: age specific and Sex specifica nalysis. World J Surg. 1997;21:313-7.
Mohanty SK, Sil K. Evaluation of modified Alvarado score in decreasing negative appendicectomy rate – our experience. IJS. 2000;62(5):342-3.