A comprehensive study on colorectal malignancies
DOI:
https://doi.org/10.18203/2349-2902.isj20191483Keywords:
Colorectal-carcinoma, Dukes’ staging, NeoplasmsAbstract
Background: Colorectal cancer is one of the cancers whose incidence is increasing globally. Coupled with the relatively sophisticated and expensive management protocols, it poses a major health systems challenge.
Methods: The present study is a cross-sectional study conducted among patients admitted with colorectal carcinoma in the General Surgery wards in a tertiary care hospital. Data was collected using a pretested pre-structured interview schedule. Relevant lab and radiographic workup was done.
Results: A total of 50 subjects were studied. The study population was largely male, illiterate and in the older age groups. The lesions were mostly left-sided and located in the rectum. 10% presented with metastasis and 16% presented as acute intestinal obstruction. Most of the lesions were in the Dukes’ stage C and mostly moderately differentiated. The common surgical procedures done in elective cases were curative abdomino-perineal obstruction and right hemicolectomy.
Conclusions: Being a disease associated with old age and non-vegetarian dietary habits and requiring advanced surgery as gold standard treatment, colorectal cancer is especially important in a country undergoing disease-favorable epidemiologic and demographic transitions like India.
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References
World Cancer Research Fund International/ American Institute for Cancer Research. Diet, nutrition, physical activity and colorectal cancer 2017. Continuous Update Project Report. Available at: https://www.wcrf.org/sites/default/files/ Colorectal-Cancer-2011-Report.pdf. Accessed on 23 March 2019.
World Health Organisation. Cancer. World Health Organisation - Fact Sheets - Cancer. 2018. Available at: https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed on 20 March 2019.
ICMR - Consensus Document For Management Of Colorectal Cancer. Available at: https://www.icmr. nic.in/sites/default/files/guidelines/Colorectal%20Cancer_0.pdf Accessed on 20 March 2019.
Galler AS, Petrelli NJ, Shakamuri SP. Rectal cancer surgery: a brief history. Surg Oncol. 2011;20(4):223–30.
Dayal S, Battersby N, Cecil T. Evolution of Surgical Treatment for Rectal Cancer: a Review. J Gastrointest Surg. 2017;21(7):1166–73.
Lirici MM, Hüscher CGS. Techniques and technology evolution of rectal cancer surgery: a history of more than a hundred years. Minim Invasive Ther Allied Technol. 2016;25(5):226–33.
Rentsch M, Schiergens T, Khandoga A, Werner J. Surgery for Colorectal Cancer - Trends, Developments, and Future Perspectives. Visc Med. 2016;32(3):184–91.
Meyer B, Are C. Current Status and Future Directions in Colorectal Cancer. Indian J Surg Oncol. 2017;8(4):455–6.
Peedikayil MC, Nair P, Seena SM, Radhakrishnan L, Sadasivan S, Naryanan VA, et al. Colorectal cancer distribution in 220 Indian patients undergoing colonoscopy. Indian J Gastroenterol. 2009;28(6):212–5.
Goh K-L, Quek K-F, Yeo GTS, Hilmi IN, Lee C-K, Hasnida N, et al. Colorectal cancer in Asians: a demographic and anatomic survey in Malaysian patients undergoing colonoscopy. Alimentary Pharmacol Therap. 2005;22(9):859–64.
Javid G, Zargar SA, Rather S, Khan AR, Khan BA, Yattoo GN, et al. Incidence of colorectal cancer in Kashmir valley, India. Indian J Gastroenterol. 2011;30(1):7–11.
Murphy G, Devesa SS, Cross AJ, Inskip PD, McGlynn KA, Cook MB. Sex disparities in colorectal cancer incidence by anatomic subsite, race and age. Int J Cancer. 2011;128(7):1668–75.
Orlich MJ, Singh PN, Sabaté J, Fan J, Sveen L, Bennett H, et al. Vegetarian dietary patterns and the risk of colorectal cancers. JAMA Intern Med. 2015;175(5):767–76.
Azeem S, Gillani SW, Siddiqui A, Jandrajupalli SB, Poh V, Syed SS. Diet and Colorectal Cancer Risk in Asia--a Systematic Review. Asian Pac J Cancer Prev. 2015;16(13):5389–96.
Ramadas A, Kandiah M. Food intake and colorectal adenomas: a case-control study in Malaysia. Asian Pac J Cancer Prev. 2009;10(5):925–32.
Mahfouz EM, Sadek RR, Abdel-Latief WM, Mosallem FA-H, Hassan EE. The role of dietary and lifestyle factors in the development of colorectal cancer: case control study in Minia, Egypt. Cent Eur J Public Health. 2014;22(4):215–22.
Nayak SP, Sasi MP, Sreejayan MP, Mandal S. A case-control study of roles of diet in colorectal carcinoma in a South Indian Population. Asian Pac J Cancer Prev. 2009;10(4):565–8.
Nashar RM, Almurshed KS. Colorectal Cancer: A Case Control Study of Dietary Factors, King Faisal Specialist Hospital and Researh Center, Riyadh, Saudi Arabia. J Family Community Med. 2008;15(2):57–64.
Kuper H, Boffetta P, Adami H-O. Tobacco use and cancer causation: association by tumour type. J Intern Med. 2002;252(3):206–24.
Mik M, Berut M, Dziki L, Trzcinski R, Dziki A. Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ. Arch Med Sci. 2017;13(1):157–62.
Sinha R, Pati S. Addressing the escalating burden of chronic diseases in India: Need for strengthening primary care. J Family Med Primary Care. 2017;6(4):701.
Hamilton W, Round A, Sharp D, Peters TJ. Clinical features of colorectal cancer before diagnosis: a population-based case-control study. Br J Cancer. 2005;93(4):399–405.
Ben-Ishay O, Peled Z, Othman A, Brauner E, Kluger Y. Clinical presentation predicts the outcome of patients with colon cancer. World J Gastrointest Surg. 2013;5(4):104–9.
Akkoca AN, Yanık S, Ozdemir ZT, Cihan FG, Sayar S, Cincin TG, et al. TNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinoma. Int J Clin Exp Med. 2014;7(9):2828–35.
Badmos K, Rotimi O, Lawal A, Osinowo A, Habeebu M, Abdulkareem F. Histopathological report of colorectal carcinoma resections: A 5-year audit in Lagos. Niger Postgrad Med J. 2018;25(1):32–6.
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