DOI: http://dx.doi.org/10.18203/2349-2902.isj20192611

Carcinoma in chronic calcific pancreatitis: review of literature

O. L. Naganath Babu, J. M. V. Amarjothi, Villalan Ramasamy, Jeyasudhahar Jesudason

Abstract


Carcinoma occurring the setting of chronic calcific pancreatitis (CCP) are usually multifocal, poorly differentiated, advanced on presentation and associated with poor overall survival. Hence it is imperative that these patients should be identified in the early stages of malignant progression where by curative resection can then be employed. If not, only palliative approaches are feasible in advanced stages. We wish to present our experience of pancreatic carcinoma in the setting of CCP along with a review of literature.

 


Keywords


CCP, Pancreatic cancer, Malignancy, CA 19-9

Full Text:

PDF

References


Gold EB, Cameron JL. Chronic pancreatitis and pancreatic cancer. N Engl J Med. 1993;328(20):1485–6.

Fernandez E, La Vecchia C, Porta M, Negri E, d’Avanzo B, Boyle P. Pancreatitis and the risk of pancreatic cancer. Pancreas. 1995;11(2):185–9.

Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al. Pancreatitis and the risk of pancreatic cancer. International pancreatitis study group. N Engl J Med. 1993;328(20):1433–7.

Farrow B, Sugiyama Y, Chen A, Uffort E, Nealon W, Mark Evers B. Inflammatory mechanisms contributing to pancreatic cancer development. Ann Surg. 2004;239(6):763–71.

Balakrishnan V, Unnikrishnan AG, Thomas V, Choudhuri G, Veeraraju P, Singh SP, et al. Chronic pancreatitis. A prospective nationwide study of 1, 086 subjects from India. JOP. 2008;9(5):593–600.

Augustine P, Ramesh H.Is tropical pancreatitis premalignant? Am J Gastroenterol. 1992;87(8):1005–8.

Yadav D, Lowenfels AB The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252–61.

Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, et al, European Registry of Hereditary, and C. Pancreatitis. Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin Gastroenterol Hepatol. 2004;2(3):252– 61.

Liao KF, Lai SW, Li CI, Chen WC. Diabetes mellitus correlates with increased risk of pancreatic cancer: a population-based cohort study in Taiwan. J Gastroenterol Hepatol. 2012;27(4):709–13.

Hariharan M, Subhalal N, Anandakumar M, Chellam VG, Iype S. Chronic calcific pancreatitis of the tropics with carcinoma. In: Balakrishnan V (ed) Chronic pancreatitis and pancreatic diabetes in India. Bangalore: L.G. Creations; 2006: 147–154.

Nouts A, Levy P, Voitot H, Bernades P. Diagnostic value of serum Ca 19-9 antigen in chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterol Clin Bio. 1998;22(2):152–9.

Perumal S, Palaniappan R, Pillai SA, Velayutham V, Sathyanesan J. Predictors of malignancy in chronic calcific pancreatitis with head mass. World J Gastrointest Surg. 2013;5(4):97–103.

Bedi MM, Gandhi MD, Jacob G, Lekha V, Venugopal A, Ramesh H. CA 19-9 to differentiate benign and malignant masses in chronic pancreatitis:is there any benefit? Indian J Gastroenterol. 2009;28(1):24–32.

Sivarman A, Muthukrishnan A, Senguttvan NB, Suchak SA, Kannan U. Predictors of malignancy in pancreatic head mass: a prospective study. Pan Afr Med J. 2011;9:30.

Sudhindran S, Krishnan P. Early detection of malignancy in tropical pancreatitis – is it possible? In: Balakrishnan V (ed). Chronic pancreatitis and pancreatic diabetes in India. Bangalore: L.G. Creations; 2006: 364–370.

Liu J, Gao J, Du Y, Li Z, Ren Y, Gu J, et al. Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer. Int J Cancer. 2012;131(3):683–91.

Pancreatic Cancer Action, 2014. Available at: http://pancreaticcanceraction.org/news/blood-testdifferentiate-pancreatic-cancer-chronic-pancreatitis. Accessed on 12 June 2017.

Gold DV, Newsome G, Liu D, Goldenberg DM. Mapping PAM4 (clivatuzumab), a monoclonal antibody in clinical trials for early detection and therapy of pancreatic ductal adenocarcinoma, to MUC5AC mucin. Mol Cancer. 2013;12:143-57.

Newmarkers shed light on pancreatic cancer. Available at: http://www.mayoclinic. org/medical-professionals/clinical-updates/digestive-diseases/newmarkers-shed-light-on-pancreatic-cancer. Accessed on 12 June 2017.

Yamada Y, Mori H, Matsumoto S, Kiyosue H, Hori Y, Hongo N. Pancreatic adenocarcinoma versus chronic pancreatitis: differentiation with triple-phase helical CT. Abdom Imaging. 2010;35:163–71.

Rijkers AP, Valkema R, Duivenvoorden HJ, van Eijck CH. Usefulness of F-18-fluorodeoxyglucose positron emission tomography to confirm suspected pancreatic cancer:a meta-analysis. Eur J Surg Oncol. 2014;40:794–804.

Wapnick S, Hadas N, Purow E, Grosberg SJ. Mass in the head of the pancreas in cholestatic jaundice: carcinoma or pancreatitis? Ann Surg. 1979;190:587-91.

Frey CF, Suzuki M, Isaji S. Treatment of chronic pancreatitis complicated by obstruction of the common bile duct or duodenum. World J Surg. 1990;14:59-69.

Minghini A, Weireter LJ, Perry RR. Specificity of elevated CA 19-9 levels in chronic pancreatitis. Surgery. 1998;124:103-5.

Augustine P, Ramesh H. Is tropical pancreatitis premalignant? Am J Gastroenterol. 1992;87:1005-8.

Saruc M, Pour PM. Diabetes and its relationship to pancreatic carcinoma. Pancreas 2003;26:381-7.