Published: 2019-04-29

Efficacy of low level infrared light therapy on wound healing in patients with chronic diabetic foot ulcers: a randomised control trial

Mimamaychet B. Sangma, Selvakumaran Selvaraju, Fremingston Marak, Simon David Dasiah


Background: A total of 52-patients with Type-2 Diabetes Mellitus having Meggitt-Wagner Grade-I of foot ulcers of at least more than 4-weeks duration, less than 6×6 cm, with negative culture were studied. Diabetic foot ulcers are serious complications of diabetes mellitus and are known to be resistant to conventional treatment. It also causes a significant cause of morbidity, mortality and financial burden. If the ulcer is left untreated they can create a severe complications. This study was designed to examine the effect of infrared radiation on the healing of diabetic foot ulcer.

Methods: This clinical trial was performed on 52 patients with diabetic foot ulcer Wagner Grade-I. Patients were classified into 26 control and 26 study group. Electromagnetic radiations in the form of photons are delivered to the ulcer site by infrared light to stimulate healing.

Results: Male preponderance was found with ratio of 2:1. Mean age of the patients was 58.82 years in control group and 52.44 years in study group. The mean HbA1C levels in the control groups were 7 (range 6.2-8.3%) and 7.2 (range 7-8%) in the study group, suggesting no biochemical differences between two groups. Mean reduction in the ulcer area was 375.30 mm in the control group and 893.56 mm in the study group and this differences between the two groups was statistically significant (p<0.010).

Conclusions: It is shown that using infrared plus routine dressing is more effective than merely routine dressing in diabetic foot ulcers and there was a significant difference in reduction of ulcer size in study group.


Diabetic foot ulcer, Infrared rays, Wound healing

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Schindl M, Kerschan K, Schindl A, Schon H, Heinzl H, Schindl L. Induction of complete wound healing in recalcitrant ulcers by low intensity laser irradiation depends on ulcer cause and size. Photodermatol Photoimmunol Photomed. 1999;15(1):18-21.

Kajagar B, Godhi A, Pandit A, Khatri S. Efficacy of low level laser therapy on wound healing in patients with chronic diabetic foot ulcers-a randomised control trial. Ind J Surg. 2012;74:359-63.

Kazemi-Khoo N. Successful treatment of diabetic foot ulcers with low level laser therapy. The Foot. 16 2016;16:184-7.

Nteleki B, Houreld NN. The use of phototherapy in the treatment of diabetic foot ulcers. J Endocrinol Metab Diabetes South Africa. 2012;17(3):128-32.

Beckmann KH, Meyer-Hamme G, Schröder S. Low level laser therapy for the treatment of diabetic foot ulcers: A critical survey. Evid Based Complement Alternat Med. 2014;2014:626127.

Kaviani A, Djavid GE, Ataie-Fashtami L, Fateh M, Ghodsi M, Salami M, et al. A randomized clinical trial on the effect of low-level laser therapy on chronic diabetic foot wound healing: a preliminary report. Photomed Laser Surg. 2011;29:109-14.

Shobhana R, Rama Rao P, Lavanya A, Viswanathan V, Ramachandra A. Cost burden to diabetic patients with foot complications-a study from southern India. J Assoc Physicians India. 2000;48(12):1147-50.

Landau Z, Migdal M, Lipovsky A, Lubart R. Visible light-induced healing of diabetic or venous foot ulcers: a placebo-controlled double-blind study. Photomed Laser Surg. 2011;29:399-404.

Minatel DG, Frade MA, Franca SC, Enwemeka CS. Phototherapy promotes healing of chronic diabetic leg ulcers that failed to respond to other therapies. Lasers Surg Med. 2009;41:433-41.

Posten W, Wrone DA, Dover JS, Arndt KA, Silapunt S, Alam M. Low-level laser therapy for wound healing: mechanism and efficacy. Dermatol Surg. 2005;31(3):334-40.

Zand N. Using low-level laser on wound healing. Laser Med. 2008;5(1):39-44.