A comparative study of preoperative intra-incisional infiltration of ceftriaxone vs. intravenous ceftriaxone for prevention of surgical site infections
Keywords:Surgical site infection, Ceftriaxone, Wound infection
Background: Surgical site infection (SSI) continues to be a major causes of post-operative morbidity, mortality since time immemorial. Many methods have been evolved to combat wound infection including concept of antisepsis and use of intravenous antibiotics. But the rate of SSI has been more or less static over the past few decades. The current study was undertaken to check effectiveness of preoperative intra-incisional infiltration of ceftriaxone for prevention of SSI.
Methods: This prospective study included 120 cases. Patients were randomly divided into two equal groups (60 each). Group A, considered control and received single dose of intravenous ceftriaxone (1 gm), whereas Group B, considered test and received intra-incisional ceftriaxone before starting procedure. If any evidence of SSI present, data recorded and swab sample was taken and sent for culture. Result of this analyzed for significance.
Results: In category A, 15 out of 60 patients (25%) developed SSI, while in category B, 3 out of 60 patients (5%) developed SSI. Escherichia coli is the commonest (72.22%) organism responsible for SSI in our study. Mean hospital stay of patients who develop SSI is nearly two times higher than who don’t develop SSI.
Conclusions: This study confirms that the preoperative intra-incisional injection of ceftriaxone has resulted in a significant reduction in SSI infection rates in all classes of wounds both clinically as well as statistically (P value < 0.005).
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