Acute mild gallstone pancreatitis: timing of cholecystectomy
DOI:
https://doi.org/10.18203/2349-2902.isj20191250Keywords:
Gallstone, Pancreatitis, CholecystectomyAbstract
Background: Cholecystectomy is essential to prevent recurrent attacks of mild acute gallstone pancreatitis, but the precise timing of cholecystectomy remains a subject of ongoing debate. The aim of this study is to address the optimal timing of cholecystectomy in patients with mild acute gallstone pancreatitis.
Methods: From September 2013 to September 2018, patients with mild acute gallstone pancreatitis were prospectively randomized to either an early laparoscopic cholecystectomy (ELC) versus a delayed laparoscopic cholecystectomy (DLC) group. Recurrent biliary complications, success and failure rate, difficulty of cholecystectomy, operative time, cholecystectomy related complications, length of admission between the two groups were evaluated.
Results: A total of 80 patients were randomized to the ELC (41 patients) and to the DLC group (39 patients). There were a statistically significant differences in the total length of hospital stay and recurrent biliary events (4.5±1.1 vs. 7.4±2.6 days, p<0.01 and 4.9% vs. 41%, p<0.001; respectively). There were no differences regarding success and failure rate, difficulty of cholecystectomy, operative time, cholecystectomy related complications, and length of index admission between both groups.
Conclusions: In mild gallstone pancreatitis, ELC results in a shorter overall hospital stay with a significant reduction in the recurrent biliary events with no apparent impact on the safety and technical difficulty of the procedure or perioperative complication rate.
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References
Ito K, Ito H, Whang EE. Timing of cholecystectomy for biliary pancreatitis:do the data support current guidelines? J Gastrointestinal Surg. 2008;12:2164-70.
Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144:1252-61.
Taylor E, Wong C. The optimal timing of laparoscopic cholecystectomy in mild gallstone pancreatitis. Am Surg. 2004;70:971-5.
Aboulian A, Chan T, Yaghoubian A, Kaji AH, Putnam B, Neville A, et al. Early cholecystectomy safely decreases hospital stay in patients with mild gallstone pancreatitis: Randomized prospective study. Ann Surg. 2010;251:615-9.
Forsmark CE, Baillie J. AGA Institute technical review on acute pancreatitis. Gastroenterology. 2007;132:2022-44.
Banks PA, Freeman ML. Practice guidelines in acute pancreatitis. Am J Gastroenterol. 2006;101:2379-400.
Uhl W, Warshaw A, Imrie C, Bassi C, McKay CJ, Lankisch PG, et al. IAP Guidelines for the Surgical Management of Acute Pancreatitis. Pancreatology. 2002;2:565-73.
Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013;13:1-15.
Tenner S, Baillie J, Dewitt J, Vege SS. American College of Gastroenterology Guidelines: management of acute pancreatitis. Am J Gastroenterol. 2013;108:1400-15.
Gullo L, Migliori M, Pezzilli R, Olah A, Farkas G, Levy P, et al. An update on recurrent acute pancreatitis:data from five European countries. Am J Gastroenterol. 2002;97:1959-62.
Nealon WH, Bawduniak J, Walser EM. Appropriate timing of cholecystectomy in patients who present with moderate to severe gallstone-associated acute pancreatitis with peripancreatic fluid collections. Ann Surg. 2004;239:741-9.
Crockett SD, Wani S, Gardner TB, Falck-Ytter Y, Barkun AN. American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis. Gastroenterol. 2018;154:1096-101.
Kelly TR, Wagner DS. Gallstone pancreatitis:a prospective randomized trial of the timing of surgery. Surgery. 1988;104:600-5.
Perez LJR, Parra JF, Dimas GA. The safety of early laparoscopic cholecystectomy (<48 h) for patients with mild gallstone pancreatitis:a systematic review of the literature and meta-analysis. CIR ESP. 2014;92:107-13.
Van Baal MC, Besselink MG, Bakker OJ, van Santvoort HC, Schaapherder AF, Nieuwenhuijs VB, et al. Timing of cholecystectomy after mild biliary pancreatitis:a systematic review. Ann Surg. 2012;255:860-6.
Nguyen GC, Rosenberg M, Chong RY, Chong CA. Early cholecystectomy and ERCP are associated with reduced readmissions for acute biliary pancreatitis:a nationwide, population-based study. Gastrointest Endosc. 2012;75:47-55.
David GG, Al-Sarira AA, Willmott S, Deakin M, Corless DJ, Slavin JP. Management of acute gallbladder disease in England. Br J Surg. 2008;95(4):472-6.
Lankisch PG, Weber-Dany B, Lerch MM. Clinical perspectives in pancreatology:compliance with acute pancreatitis guidelines in Germany. Pancreatology. 2005;5:591-3.
Monkhouse SJ, Court EL, Dash I, Coombs NJ. Two-week target for laparoscopic cholecystectomy following gallstone pancreatitis is achievable and cost neutral. Br J Surg. 2009;96:751-5.
Jee SL, Jarmin R, Lim KF, Raman K. Outcomes of early versus delayed cholecystectomy in patients with mild to moderate acute biliary pancreatitis: A randomized prospective study. Asian J Surg. 2018;41:47-54.
Toouli J, Brooke-Smith M, Bassi C, et al. Guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol. 2002;17:15-39.
Pezzilli R, Uomo G, Gabbrielli A, Zerbi A, Frulloni L, De Rai P, et al. A prospective multicentre survey on the treatment of acute pancreatitis in Italy. Dig Liver Dis. 2007;39:838-46.
Johnstone M, Marriott P, Royle TJ, et al. The impact of timing of cholecystectomy following gallstone pancreatitis. Surgeon. 2014;12(3):134-40.
Wilson CT, de Moya MA. Cholecystectomy for acute gallstone pancreatitis:early vs delayed approach. Scand J Surg. 2010;99(2):81-5.
Tang SC, Stain G, Tang EF, Berne TV. Management of acute pancreatitis: from surgery to interventional intensive care. Gut. 2005;54:426-36.
Sinha R. Early laparoscopic cholecystectomy in acute biliary pancreatitis: the optimal choice? HPB Surg. 2008;10:332-5.
Sanjay M, Kapil S, Mahavir J, Jangvir S, Prakash GS, Pal SV. Comparative Evaluation of Early Laparoscopic Cholecystectomy for Mild Gallstone Pancreatitis vs Acute Cholecystitis. Hellenic J Surg. 2017;89:4-12.
da Costa DW, Bouwense SA, Schepers NJ, Besselink MG, van Santvoort HC, van Brunschot S, et al. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO):a multicentre randomised controlled trial. Lancet. 2015;386:1261-8.
Kamal A, Akhuemonkhan E, Akshintala VS, Singh VK, Kalloo AN, Hutfless SM. Effectiveness of Guideline Recommended Cholecystectomy to Prevent Recurrent Pancreatitis. Am J Gastroenterol. .2017;112:503-10.
Al-Qahtani HH. Early versus interval cholecystectomy after mild acute gallstone pancreatitis:A 10 year experience in central Saudi Arabia. Journal of Taibah University Medical Sci. 2014;9:322-7.
Karvonen J, Salminen P, Gronroos JM. Bile duct injuries during open and laparoscopic cholecystectomy in the laparoscopic era:alarming trends. Surg Endosc. 2011;25(9):2906e10.
Flum DR, Cheadle A, Prela C, Dellinger EP, Chan L. Bile duct injury during cholecystectomy and survival in medicare beneficiaries. J Am Med Assoc. 2003;290(16):2168-73.
Trust MD, Sheffield KM, Boyd CA, Benarroch-Gampel J, Zhang D, Townsend Jr CM, et al. Gallstone pancreatitis in older patients: are we operating enough? Surgery. 2011;150(3):515-25.