Assessment of predictors and prognostic factors for locoregional recurrent breast cancer
DOI:
https://doi.org/10.18203/2349-2902.isj20185489Keywords:
Conservative breast therapy, Locoregional recurrent breast cancer, Modified radical mastectomyAbstract
Background: Assessment of predictors and prognostic factors of locoregional recurrent breast cancer will help in management of those patients. The aim of this study was to assess and identify the predictors and prognostic factors for locoregional current breast cancer.
Methods: This prospective study will be carried out on 50 female patients with history of breast cancer underwent surgical procedures either modified radical mastectomy (MRM) or conservative breast surgery (CBS) and adjuvant therapy (chemotherapy, radiotherapy, hormonal therapy).
Results: Significant relationship between recurrence of breast cancer and Oral contraceptive pills of the studied female patients with history of breast cancer underwent surgery.
Conclusions: Number of positive lymph nodes, lympho-vascular invasion, positive safety margin and presence of extensive intra-ductal component all these factors increase risk of recurrent breast cancer.
References
Li Z, Sergent F, Bolla M, Zhou Y, Gabelle‑Flandin I. Prognostic factors of second primary contralateral breast cancer in early‑stage breast cancer. Oncol Letters. 2015 Jan 1;9(1):245-51.
Anderson BO, Ilbawi AM, El Saghir NS. Breast cancer in low and middle income countries (LMIC s): a shifting tide in global health. Breast J. 2015 Jan;21(1):111-8.
Cabioglu N, Özkurt E, Polat AK. Local-Regional Recurrence After Breast-Conservation Treatment or Mastectomy. InBreast Disease. 2016:465-488. Springer, Cham.
Witteveen A, Kwast AB, Sonke GS, IJzerman MJ, Siesling S. Survival after locoregional recurrence or second primary breast cancer: impact of the disease-free interval. PloS One. 2015 Apr 10;10(4):e0120832.
Senkus E, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rutgers E, et al. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015; 26(suppl_5):8-30.
Aalders KC, Postma EL, Strobbe LJ, Der Heiden-Van Der Loo V, Sonke GS, et al. Contemporary locoregional recurrence rates in young patients with early-stage breast cancer. J Clin Oncol. 2016 Jun 20;34(18):2107-14.
Jobsen JJ, Van der Palen J, Meerwaldt JH. The impact of age on local control in women with pT1 breast cancer treated with conservative surgery and radiation therapy. Eur J Cancer. 2001 Oct 1;37(15):1820-7.
Arvold ND, Taghian AG, Niemierko A, et al: Age, breast cancer subtype approximation, and local recurrence after breast-conserving therapy. J Clin Oncol. 2011; 29(29):3885-91.
Derkx F, Maaskant-Braat AJ, van der Sangen MJ, et al. Staging and management of axillary lymph nodes in patients with local recurrence in the breast or chest wall after a previous negative sentinel node procedure. Eur J Surg Oncol. 2010; 36(7):646-51.
