Prevention of subclinical deep vein thrombosis in abdominal surgeries
DOI:
https://doi.org/10.18203/2349-2902.isj20182748Keywords:
Abdominal surgeries, DVT, Early mobilization, Low molecular heparinAbstract
Background: Deep vein thrombosis (DVT) is a common but elusive illness that can result in disability and death if not recognized and treated effectively. The reported incidence has not changed much over past couple of decades. The aim of this study was to identify the risk of deep vein thrombosis related to the number of days of immobility and the role of low molecular weight heparin in the prevention of deep vein thrombosis.
Methods: A total of hundred (n=100) patients undergoing laparotomy were studied in the post-operative period between January 2014 and December 2016. Patients were divided into two groups alternatively; Group I patients did not receive any DVT prophylaxis and Group II patients were given low molecular weight heparin once a day till mobilization. From 3rdPOD, all the patients were evaluated with detailed history and lower limb examination. D-dimer study was done in all the patients and if positive then followed by Color Venous Doppler. Regular follow-ups were done weekly once for a month, every two weeks for next month and once a month thereafter, minimum for 6 months.
Results: A total of hundred (n=100) patients, including 65 men and 35 women, with median age of 40 years underwent laparotomies in 2 years by a single unit. The incidence of Lower Limb DVT in Group I was 8%. The risk factors associated with DVT were sex, BMI, smoking and Malignancy. The signs and symptoms associated with DVT were swelling of lower limbs, pain and tenderness, fever and Homan’s and Moses signs. The D-dimer test results were positive in 9 patients. Color Venous Doppler identified DVT in 8 patients. On regular follow- ups, remissions of clinical symptoms were recorded and repeat Doppler scans showed recanalization in all the patients after 6 months.
Conclusions: Deep Vein Thrombosis is multifactorial, and post-operative patients account for majority of cases. Early mobilization and Prophylactic Low Molecular Heparin prevents DVT in abdominal surgeries.
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References
Budnik I, Brill A. Immune Factors in deep vein thrombosis initiation. Trends in immunology. 2018;S1471-4906(18)30087-5.
Muleledhu AL, Galukande M, Makobore P, Mwambu T, Ameda F, Kiguli-Malwadde E. Deep venous thrombosis after major abdominal surgery in a Ugandan hospital: a prospective study. Int J Emerg Med. 2013;6(1):43.
Heit JA, Melton LJ, Lohse CM, Petterson TM, Silverstein MD, Mohr DN, O’Fallon WM. Incidence of venous thromboembolism in hospitalized patients vs community residents. Mayo Clin Proceed. 2001;76(11)1102-10.
Swenson CW, Berger MB, Kamdar NS, Campbell DA, Jr, Morgan DM. Risk factors for venous thromboembolism after hysterectomy. Obstet Gynecol. 2015;125:1139-44.
Heit JA, Petterson TM, Farmer SA, Bailey KR, Melton LJ. Trends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism: A 35-Year Population-Based Study. Blood. 2006;108:430a.
Heit JA. The Epidemiology of Venous Thromboembolism in the Community. Arterioscler Thromb Vasc Biol. 2008;28(3): 370-2.
Bergqvist D. Venous thromboembolism: a review of risk and prevention in colorectal surgery patients Dis Colon Rectum. 2006;49(10):1620-8.
Gallus AS Preventing venous thromboembolism in general medical inpatients and after an ischaemic stroke. Haemostasis. 2000;30 (Suppl 2):64-71.
Xu W, Zhang T, Yang Z, Nie L Effect of different types of anticoagulants in the prevention of venous thrombosis in the operation of knee joint bone operation Pak J Pharm Sci. 2018;31(3(Special)):1093-7.
Okuhara A, Navarro TP, Procópio RJ, Bernardes Rde C, Oliveira Lde C, et al Incidence of deep vein thrombosis and quality of venous thromboembolism prophylaxis. Rev Col Bras Cir. 2014;41(1):2-6.
Arnold DM, Kahn SR, Shrier I. Missed opportunities for prevention of venous thromboembolism: an evaluation of the use of thromboprophylaxis guidelines. Chest. 2001;120(6):1964-71.
Stone J, Hangge P, Albadawi H, Wallace A, Shamoun F, Knuttien MG, Naidu S, Oklu R. Deep vein thrombosis: pathogenesis, diagnosis, and medical management. Cardiovascu Diag Therap. 2017;7(3):S276-84.
Markovic-Denic L, Zivkovic K, Lesic A, Bumbasirevic V, Dubljanin-Raspopovic E, Bumbasirevic M. Risk factors and distribution of symptomatic venous thromboembolism in total hip and knee replacements: prospective study. Int Orthop. 2012;36(6):1299-305.
Kumar DR, Hanlin E, Glurich I, Mazza JJ, Yale SH. Virchow's contribution to the understanding of thrombosis and cellular biology. Clin Med Res. 2010;8(3-4):168-72.
Mammen EF. Pathogenesis of venous thrombosis. Chest. 1992;102(6 Suppl):640S-644S.
Pulivarthi S, Gurram MK. Effectiveness of d-dimer as a screening test for venous thromboembolism: an update. N Am J Med Sci. 2014;6(10):491-9.
Sugimachi K, Tajiri H, Kinjo N, Ikebe M, Wang H, Tanaka K, et al. Incidence and predictors of deep venous thrombosis after abdominal oncologic surgery: Prospective Doppler ultrasound screening. J Surg Res. 2012;178(2):657-61.
Bates SM, Jaeschke R, Stevens SM, Goodacre S, Wells PS, Stevenson MD, et al. Diagnosis of DVT: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;41(2):e351S-418S.
Luksameearunothai K, Sa-ngasoongsong P, Kulachote N, Thamyongkit S, Fuangfa P, Chanplakorn P, Woratanarat P, Suphachatwong C. Usefulness of clinical predictors for preoperative screening of deep vein thrombosis in hip fractures. BMC musculoskeletal disorders. 2017 Dec;18(1):208.
Gould MK, Garcia DA, Wren SM, Karanicolas PJ. Prevention of VTE in Nonorthopedic Surgical Patients Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2):e227S-77.
David A. Garcia, Trevor P. Baglin, Jeffrey I. Weitz, Meyer Michel Samama, “Parenteral Anticoagulants Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest. 2012;141(2):e24S-43.
Sang CQ, Zhao N, Zhang J, Wang SZ, Guo SL, Li SH, et al. Different combination strategies for prophylaxis of venous thromboembolism in patients: A prospective multicentre randomized controlled study. Sci Report. 20188(1):8277.
Witt DM, Clark NP, Kaatz S, Schnurr T, Ansell JE. Guidance for the practical management of warfarin therapy in the treatment of venous thromboembolism. J Thrombosis Thrombolysis. 2016;41(1):187-205.
Charles Eby. Warfarin Pharmacogenetics: does more accurate dosing benefit patients? Semin Thromb Hemost. 2012;38(7):661-6.