DOI: http://dx.doi.org/10.18203/2349-2902.isj20182394

The state of dyslipidemia after laparoscopic sleeve gastrectomy

Ahmed Mahmoud Hussein

Abstract


Background: Obesity and dyslipidemia have a strong relation to the development of cardiovascular diseases. Bariatric surgery is directed towards the loss of patients weight and resolution of comorbidities as hyperlipidemia. Laparoscopic sleeve gastrectomy, a feasible restrictive procedure, is one the most popular and successful operations for achieving this purpose. The aim of present study was to evaluate the effect of laparoscopic sleeve gastrectomy on the lipid profile, comparing preoperative with postoperative results 12 months after surgery.

Methods: This study included fifty morbidly obese cases that underwent laparoscopic sleeve gastrectomy (LSG). Preoperative and postoperative BMI and lipid parameters were documented and analysed at 12 months postoperatively.

Results: The mean age of the studied group ±SD was 32.7±9.2 years, female predominance was found. BMI improved significantly after the LSG procedure with a mean±SD of 32.2±4 kg/m2. A significant improvement of dyslipidemia was found with a p-value (<0.001) regarding the mean level±SD of total cholesterol (TC) (180.5±25mg/dl), triglycerides (TG) (127.2±14.7mg/dl), low density lipoprotein (LDL) (94.2±14.5mg/dl) and high density lipoprotein (HDL) (48.4±5.6 mg/dl).

Conclusions: Laparoscopic sleeve gastrectomy is a feasible and successful operation in reducing the body weight and subsequently improving the dyslipidemia of the morbid obese individuals.


Keywords


Cholesterol, Dyslipidemia, Hyperlipidemia, Morbid obesity, Sleeve gastrectomy

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References


- Szczuko M, Komorniak N, Hoffmann M, Walczak J, Jaroszek A, Kowalewski B, et al. Body Weight Reduction and Biochemical Parameters of the Patients After RYGB and SG Bariatric Procedures in 12-Month Observation. Obes Surg. 2017 Apr;27(4):940-947.

- Keleidari B, Mahmoudie M, Anaraki AG, Shahraki MS, Jamalouee SD, Gharzi M, et al. Six month-follow up of laparoscopic sleeve gastrectomy. Adv Biomed Res. 2016 Mar 16;5:49.

- Waldmann E, Hüttl TP, Göke B, Lang R, Parhofer KG. Effect of sleeve gastrectomy on postprandial lipoprotein metabolism in morbidly obese patients. Lipids Health Dis. 2013 Jun 1;12:82.

- Hady HR, Dadan J, Gołaszewski P, Safiejko K. Impact of laparoscopic sleeve gastrectomy on body mass index, ghrelin, insulin and lipid levels in 100 obese patients. Wideochir Inne Tech Maloinwazyjne. 2012 Dec;7(4):251-9.

- Al Khalifa K, Al Ansari A, Alsayed AR, Violato C. The impact of sleeve gastrectomy on hyperlipidemia: a systematic review. J Obes. 2013;2013:643530.

- Abusnana S, Abdi S, Tagure B, Elbagir M, Maleckas A. Bariatric surgery outcomes: a single-center study in the United Arab Emirates. Diabetes Metab Syndr Obes. 2015 Sep 18;8:461-71.

- Bužga M, Holéczy P, Svagera Z, Svorc P Jr, Zavadilová V. Effects of sleeve gastrectomy on parameters of lipid and glucose metabolism in obese women - 6 months after operation. Wideochir Inne Tech Maloinwazyjne. 2013 Mar;8(1):22-8

- Hassan MM, Sharaf SA, Soliman HM, Al-Wakeel NA. Dyslipidemia: A Cardiovascular Risk Factor in Type 1 Diabetes and Its Correlations. J Diabetes Metab 2015; 6:586.

- Heffron SP, Parikh A, Volodarskiy A, Ren-Fielding C, Schwartzbard A, Nicholson J, et al. Changes in Lipid Profile of Obese Patients Following Contemporary Bariatric Surgery: A Meta-Analysis. Am J Med. 2016 Sep;129(9):952-9.

- Buchwald H. Lowering of cholesterol absorption and blood levels by ileal exclusion. Experimental basis and preliminary clinical report. Circulation. 1964; 29:713–20. [PubMed: 14156865]

- Buchwald H, Varco RL, Matts JP, Long JM, Fitch LL, Campbell GS, et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). The New England journal of medicine. 1990; 323:946–55. [PubMed: 2205799]

- Shi X, Karmali S, Sharma AM, Birch DW : A review of laparoscopic sleeve gastrectomy for morbid obesity. Obes Surg. 2010 Aug;20(8):1171-7.

- Péquignot A, Dhahri A, Verhaeghe P, Desailloud R, Lalau JD, Regimbeau JM. Efficiency of laparoscopic sleeve gastrectomy on metabolic syndrome disorders: Two years results. J Visc Surg. 2012;149:e350–5.

- Helmiö M, Victorzon M, Ovaska J, Leivonen M, Juuti A, Peromaa-Haavisto P, et al. Comparison of short-term outcome of laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: A prospective randomized controlled multicenter SLEEVEPASS study with 6-month follow-up. Scand J Surg. 2014;103:175–81

- Himpens J, Dobbeleir J, Peeters G. Long-term results of laparoscopic sleeve gastrectomy for obesity. Ann Surg. 2010;252:319–24.

- Abd Ellatif ME, Abdallah E, Askar W, Thabet W, Aboushady M, Abbas AE, et al. Long term predictors of success after laparoscopic sleeve gastrectomy. Int J Surg. 2014;12:504–8.

- Mizrahi I, Alkurd A, Ghanem M, Zugayar D, Mazeh H, Eid A, et al. Outcomes of laparoscopic sleeve gastrectomy in patients older than 60 telears. Obes Surg. 2014;24:855–60.

- Kang JH, Le QA : Effectiveness of bariatric surgical procedures: A systematic review and network meta-analysis of randomized controlled trials. Medicine (Baltimore). 2017 Nov;96(46):e8632.

- To VT, Hüttl TP, Lang R, Piotrowski K, Parhofer KG. Changes in body weight, glucose homeostasis, lipid profiles, and metabolic syndrome after restrictive bariatric surgery. Exp Clin Endocrinol Diabetes. 2012 Oct;120(9):547-52

- Erol V, Yılmaz TH, Tuncalı B, Arslan B, Gülay H. Changes in serum lipid levels after laparoscopic sleeve gastrectomy in morbidly obese dyslipidemic and normolipidemic patients. Acta Chir Belg. 2017 Dec 17:1-6.

- Milone M, Lupoli R, Maietta P, Di Minno A, Bianco P, Ambrosino P, et al. Lipid profile changes in patients undergoing bariatric surgery: a comparative study between sleeve gastrectomy and mini-gastric bypass. Int J Surg. 2015 Feb;14:28-32.