Association of Helicobacter pylori infection and stomach cancer: our experience

NG. Javan, Wormi Sharon


Background: Infection with Helicobacter pylori (H. pylori) has been linked with chronic atrophic gastritis, an inflammatory precursor of gastric adenocarcinoma. There are data on the epidemiology, pathophysiology, and histology of this disease that show that Helicobacter pylori gastritis has an important role in gastric carcinogenesis. However, it has to be considered that only very few of those infected with Helicobacter pylori will develop gastric cancer. Hence, it will be a major target of future research to identify individuals who carry a greater risk for developing gastric cancer, and therefore may benefit from eradication of Helicobacter pylori in terms of gastric cancer prevention. Various studies revealed that approximately more than 50% of the world’s human population is infected by Helicobacter pylori. In underdeveloped countries, this association is shown to be much higher according to different studies.

Methods: This study was conducted over a period of 36 months from 1st January 2014 till December 31st, 2016. All patients who underwent Gastrectomy during this period were taken. All specimens were investigated to see presence of helicobacter pylori by histological examination. A total of 50 Gastrectomy was performed by one surgical team over 36-month period.

Results: Out of 50 patients, Helicobacter pylori positivity was seen in 33 (66%) cases by histopathological examination (HPE). Gastric cancer is more prevalent among males 31 (62%) as compared to 19 (38%) in females. It is more common among the older age group.

Conclusions: Helicobacter pylori infection is higher in prevalence in cases of stomach cancer. Present study also showed that there is significant association of Helicobacter pylori infection with gastric carcinoma. Helicobacter pylori infection could be one of the etiological factors for gastric carcinoma.


Helicobacter pylori, Helicobacter pylori IARC, Histopathological examination MALT lymphomas, International agency for research on cancer HPE, Mucosa associated lymphoid tissue lymphomas, Stomach carcinoma

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Dixon MF. Campylobacter pylori and chronic gastritis. In: Rathbone BJ, Heatley RV, eds. Campylobacter pylori and gastroduodenal disease. Oxford: Blackwell Scientific Publications, 1989:106-16.

World Health Organization. International Agency for Research on Cancer, IARC. Monograph on the evaluation of carcinogenic risks to human: Schistosomes, Liver flukes and Helicobacter pylori. Lyon France. IARC. 1994;61:177-240.

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA: Cancer J Clinicians. 2005;55(2):74-108.

Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK. Helicobacter pylori infection and the risk of gastric carcinoma. N Eng J Med. 1991;325(16):1127-31.

Muir C, Powell J, Manck T, Whelan S. Cancer incidence in Five Continents volume V. IARC (scientific publications no.88); 1987.

Mohandas KM, Nagral A. Epidemiology of digestive tract cancers in India. II. Stomach, and gastrointestinal lymphomas. Indian J Gastroenterol: Off J Indian Soc Gastroenterol. 1998;17(1):24-7.

Fuchs CS, Mayor RJ. Gastric carcinoma. N Engl J Med. 1995; 333(1):32-41.

Parkin DM. The global health burden of infection‐associated cancers in the year 2002. Int J Cancer. 2006;118(12):3030-44.

Knigge KL. The role of H. pylori in gastrointestinal disease: a guide to identification and eradication. Postgrad Med. 2001;110(31):71-82.

Warren JR, Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1:1273-75.

Forman D, Newell DG, Fullerton F, Yarnell JWG, Stacey AR, Wald N, Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Br Med J. 1991;302:1302-5.

Wang C, Yuan Y, Hunt RH. The association between Helicobacter pylori infection and early gastric cancer: a meta-analysis. Am J Gastroenterol. 2007;102(8):1789-98.

Nakamura RM. Laboratory tests for the evaluation of Helicobacter pylori infections. J Clin Lab Analysis. 2001;15(6):301-7.

Basnet R.B, Shrestha B, Joshi RD, et al Prevalence of helicobacter pylori in gastric biopsy specimens, PMJN. 2006;6.

Ries LA. SEER cancer statistics review, 1973-1998. Journal. Bethesda: National Cancer Institute. 2001:1-20.

Julian AA, Timothy CW. Adenocarcinoma and other tumors of the stomach. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtrean's Gastrointestinal and Liver disease. 9th edition. Saunders, Elsevier; 2010:887.

Afridi SP, Bano F, Shafiq-ur-Rahman. Pattern and presentation of carcinoma stomach. J Coll Physicians Surg Pak. 2011;21:161-3.

Satti MB, Al-Quorain AA, Al-Gindan YM, Al Hamdan AA, Al-Idrissi HY. Gastric malignancy: clinicopathologic spectrum and relationship to Helicobacter pylori infection. Saudi J Gastroenterol. 2005;11(3):149.

Cherian JV, Sivaraman R, Muthusamy AK, Venkataraman J. Stomach carcinoma in the Indian subcontinent: a 16-year trend. Saudi J Gastroenterol. 2007;13(3):114-7.

Qurieshi MA, Masoodi MA, Kadla SA, Ahmad SZ, Gangadharan P. Gastric cancer in Kashmir. Asia Pacific J Cancer Preventation. 2011;12:303-7.

Devesa SS, Blot WJ, Fraumeni Jr JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer: Interdisciplinary Int J Am Cancer Soc. 1998;83(10):2049-53.

Goto H, Ohmiya N, Kamiya K, Ando N, Sakata T, Hayakawa T. Did gastric cancer vary over 30 years in Japan?. Gastroenterol. 2001;120(5):A255.

Lee JY, Kim HY, Kim KH, Jang HJ, Kim JB, Lee JH, et al. No changing trends in incidence of gastric cardia cancer in Korea. J Korean Med Sci. 2003;18(1):53-7.

Abdi-Rad A, Ghaderi-Sohi S, Nadimi-Barfroosh H, Emami S. Trend in incidence of gastric adenocarcinoma by tumor location from 1969-2004: a study in one referral center in Iran. Diagnostic Pathol. 2006 Dec;1(1):5.

Shibata T, Imoto I, Ohuchi Y, Taguchi Y, Takaji S, Ikemura N et al. Helicobacter pylori infection in patients with gastric carcinoma in biopsy and surgical resection specimens. Cancer: Interdisciplinary Int J Am Cancer Soc. 1996;77(6):1044-9.

Craanen ME, Blok P, Dekker W, Tytgat GN. Helicobacter pylori and early gastric cancer. Gut. 1994;35(10):1372-4.

Demirel A, Oncel S, Çaydere M, Dogan A, Usten H, Ongoren A. Helicobacter pylori infection in gastrectomy specimens. Internet J Oncol. 1999;1(1).

Zhang HM, Wakisaka N, Maeda O, Yamamoto T. Vitamin C inhibits the growth of a bacterial risk factor for gastric carcinoma: Helicobacter pylori. Cancer: Interdisciplinary Int J Am Cancer Soc. 1997;80(10):1897-903.

Konturek SJ, Bielański W, Płonka M, Pawlik T, Pepera J, Konturek PC, et al. Helicobacter pylori, non-steroidal anti-inflammatory drugs and smoking in risk pattern of gastroduodenal ulcers. Scand J Gastroenterol. 2003;38(9):923-30.

Wang RT, Wang T, Chen K. Helicobacter pylori infection and gastric cancer: evidence from a retrospective cohort study and nested case-control study in China. World J Gastroenterol. 2002;8(6):1103-110.

Takenaka R, Okada H, Kato J, Makidono C, Hori S, Kawahara Y, et al. Helicobacter pylori eradication reduced the incidence of gastric cancer, especially of the intestinal type. Alimentary Pharmacol Therapeutics. 2007;25(7):805-12.

Kim JS, Chung SJ, Choi YS, Cheon JH, Kim CW, Kim SG, et al. H. pylori eradication for low-grade gastric mucosa-associated lymphoid tissue lymphoma is more successful in inducing remission in distal compared to proximal disease. Br J Cancer. 2007;7:1324-8.

Kürşad TM, Süleyman A, Mahmut İ, Hüsniye D, Emel A et al. Helicobacter pylori infection in gastric carcinoma in the Van region of Turkey. Turk J Gastroenterol. 1999;10(1):36-9.

Bhasin DK, Kakkar N, Sharma BC, H. pylori in gastric cancer in India. Trop Gastroenterol. 1999;20(2):70-2.