Kissing sebaceous carcinoma of the eyelids: a rare case report

Surya Rao Rao Venkata Mahipathy, Senthil Kumar Azhisoor Chandrasekhar, Alagar Raja Durairaj, Vimal Chander Rajamanohar, Narayanamurthy Sundaramurthy, Manimaran Ramachandran


Sebaceous gland carcinomas are tumours of the skin adnexa which occur around the periocular region of elderly females. It is a rare malignancy usually involving the upper eyelid and has an indolent course. Treatment is surgical excision of the lesion with lid reconstruction. Here authors discuss a case of swellings involving both the eyelids of an elderly female diagnosed as sebaceous gland carcinoma on biopsy for which wide local excision and primary eyelid repair was done. This case has been presented as the lesion masquerades as a benign one but is malignant with multifocal spread.


Carcinoma, Eyelids, Malignant, Rare, Sebaceous

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Buitrago W, Joseph AK. Sebaceous carcinoma: The great masquerader: Emerging concepts in diagnosis and treatment. Dermatol Ther. 2008;21(6): 459-66.

Straatsma BR. Meibomian gland tumors. Arch Ophthalmol. 1956 July;56(1):71-93.

Ni C, Kou PK. Meibomian gland carcinoma: A clinico-pathological study of 156 cases with long-period follow up of 100 cases. Jpn J Ophthalmol. 1979;23:388-401.

Rao NA, Hidayat AA, Mclean IW, Zimmerman LE. Sebaceous carcinomas of the ocular adnexa: A clinico-pathological study of 104 cases, with five year follow up data. Human Pathol. 1982 Feb;13(2):113-22.

Zurcher M, Hinstchich CR, Garner A, Bunce C, Collin JR. Sebaceous carcinoma of the eyelid: A clinicopathological study. Br J Ophthalmolo. 1998 Sep;82(9):1049-55.

Shields JA, Demirci H, Marr BP, Eagle RC, Jr, Shields CL. Sebaceous carcinoma of the eyelids: Personal experience with 60 cases. Ophthalmol. 2004;111(12):2151-7.

Sweebe EC, Cogan DG. Adenocarcinoma of the meibomian gland; a pseudochalazion entity. Arch Ophthalmol. 1959 Feb;61(2):282-90.

Russell WG, Page DL, Hough AJ, Rogers LW. Sebaceous carcinoma of meibomian gland origin. The diagnostic importance of pagetoid spread of neoplastic cells. Am J ClinPathol. 1980 Apr;73(4):504-11.

Cook BE, Bartley GB. Treatment options and future prospects for the management of eyelids malignancie. Opthalmol. 2001 Nov;108(11):2088-98.

Ginsber J. Present status of Meibomian gland carcinoma. Arch Ophthalmol. 1965 Feb;73:271-7.

Epstein GA, Putterman AM. Sebaceous adenocarcinoma of the eyelid. Ophthalmic Surg. 1983 Nov;14(11):935-40.

Ahmad J, Mathes DW, Itani KM. Reconstruction of the eyelids after Mohs surgery. Semin Plast Surg. 2008;22(4):306-10.

Parodi PC, Faini G, De Biasio F, RampinoCordaro E, Guarneri GF, Miani F. Full-thickness lower eyelid reconstruction with a conchalchondro-perichondral graft and local coverage with Mio-cutaneous flaps--our divisional experience. J Oral Maxillofac Surg. 2008;66(9):1826-32.

Harvey DT, Taylor RS, Itani KM, Loewinger RJ. Mohs Micrographic Surgery of the Eyelid: An Overview of Anatomy, Pathophysiology, and Reconstruction Options. Dermatol Surg. 2013;39(5):673-97.

Stein JD, Antonyshyn OM. Aesthetic eyelid reconstruction. ClinPlast Surg. 2009;36(3):379-97.

Jewett BS, Shocley WW. Reconstructive options for periocular defects.Otolaryngol Clin North Am. 2001;34(3):601-25.

Miyamoto J, Nakajima T, Nagasao T, Konno E, Okabe K, Tanaka T. Full thickness reconstruction of the eyelid with rotation flap based on orbicularis oculi muscle and palatal mucosal graft: long-term results in 12 cases. J Plast Reconstr Aesthet Surg. 2009;62(11):1389-94.

Moesen I, Paridaens D. A technique for the reconstruction of lower eyelid marginal defects. Br J Ophthalmol. 2007;91(12):1695-7.

Ducic Y, Burye M. Nasolabial flap reconstruction of oral cavity defects: a case report of 18 cases. J Oral Maxillofac Surg. 2000 Oct;58(10):1104-8.

Shields CL, Naseripour M, Shields JA, Eagle RC. Topical mitomycin C for pagetoid invasion of the conjuctiva by eylid sebaceous gland carcinoma. Ophthalmol. 2002 Nov;109(11):2129-33.

Nunery WR, Welsh MG, McCord CD., Jr Recurrence of Sebaceous carcinoma of the eyelid after radiation therapy. Am J Ophthalmol. 1983 Jul;96(1):10-5.

Hendley RL, Reiser JC, Cavanagh HD. Primary radiation therapy for meibomian gland carcinoma. Am J Ophthalmol. 1979 Feb;87(2):206-9.