Giant solitary trichoepithelioma masquerading as basal cell carcinoma
DOI:
https://doi.org/10.18203/2349-2902.isj20182790Keywords:
Adnexal, Benign, Immunohistochemistry, RareAbstract
Trichoepithelioma is a rare benign adnexal tumour which can be of solitary non-familial type or multiple familial trichoepitheliomas. Here authors describe a middle-aged patient who presented with a swelling of the left nasolabial region diagnosed clinically as a basal cell carcinoma but proved to be a giant solitary trichoepithelioma (GST) following histopathological examination. This case is presented due to the rarity and the difficulty encountered in diagnosis of the case.
References
Weedon D. Weedon's skin pathology. Section 7 Tumors London: Elsevier Publications, Churchill livingstone;2010:760-762.
Samaka RM, Bakry OA, Seleit I, Abdelwahed MM, Hassan RA. Multiple familial trichoepithelioma with malignant transformation. Indian J Dermatol. 2013 Sep;58(5): 409.
Pincus LB, McCalmont TH, Neuhaus IM, Kasper R, Oh DH. Basal cell carcinomas arising within multiple trichoepitheliomas. J Cutan Pathol. 2008 Oct;35Suppl 1:59-64.
Lee KH, Kim JE, Cho BK, Kim YC, Park CJ. Malignant transformation of multiple familial trichoepithelioma: Case report and literature review. Acta Derm Venereol. 2008;88:43-6.
Pham TT, Selim MA, Jr, Burchette JL, Madden J, Turner J, Herman C. CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol. 2006; 33(2): 123-8.
Fernandez-Flores A. Advanced differentiation in trichoepithelioma and basal cell carcinoma investigated by immunohistochemistry against neurofilaments. Folia Histochem Cytobiol. 2009;47:61-4.
Elder DE, Elenitsas R, Johnson BL, Murphy GF, Xu X. Tumors of the epidermal appendages. Lever's Histopathology of the skin. 10th ed. Philadalphia: Lippincott Williams and Wilkins; 2009:857-9.
Sellheyer K, Nelson P. Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens. J Cutan Pathol. 2011 Jul;38(7): 542-50.
Doherty SD, Barrett TL, Joseph AK. Brooke-Spiegler syndrome: Report of a case of multiple cylindromas and trichoepitheliomas. Dermatol Online J.2008;14(7):8.
Kaur T, Puri KJ, Chahal KS, Budhwar J. Multiple Familial Trichoepitheliomas: A case report and review. Egypt Dermatol Online J. 2012;8(2):11.