DOI: http://dx.doi.org/10.18203/2349-2902.isj20182789

Metaplastic carcinoma breast (IDC and chondrosarcoma): a rare entity

Deepesh Kalra, Bhanu Kaushik, Shalu Gupta, Pradeep Tanwar, Sami Anwar Khan

Abstract


Metaplastic breast carcinoma is very rare neoplasm. Authors report a case of metaplastic breast carcinoma containing characteristic features of infiltrating ductal carcinoma and chondrosarcoma. A 62-year-old female presented with complaint of a lump in the right breast for the last 2 years. FNAC was suggestive of mucinous tumour. Tru-cut biopsy had been performed outside the institution, which was suggestive of a Ductal carcinoma with mucinous component. Modified radical mastectomy of the right breast was performed and histopathology was suggestive of infiltrating ductal carcinoma and chondrosarcoma of the right breast. All resected lymph nodes were free of metastasis. Immunohistochemistry was suggestive of a metaplastic carcinoma with components of ductal carcinoma and chondrosarcoma with moderately positive ER, negative PR, positive Pancytokeratin in ductal carcinoma component, positive S-100 and KI-67.


Keywords


Breast carcinoma, Chondrosarcoma, Metaplastic carcinoma

Full Text:

PDF

References


Brenner RJ, Turner RR, Schiller V, Arndt RD, Giuliano A. Metaplastic carcinoma of the breast: report of three cases. Cancer. 1998;82:1082-7.

Beltaos E, Banerjee TK. Chondrosarcoma of the breast: Report of 2 cases. Am J Clin Pathol. 1979;71:345-9.

Feder JM, de Paredes ES, Hogge P, Wilken JJ. Unusual breast lesions: radiologic-pathologic correlation. Radiographics. 1999;19(suppl):S11-26.

Kurian KM, Al-Nafussi A. Sarcomatoid/ metaplastic carcinoma of the breast: a clinicopathological study of 12 cases. Histopathol. 2002;40:58-64.

Oberman HA. Metaplastic carcinoma of breast: A clinicopathological study of 29 patients. Am J Surg Pathol. 1987;11:918-29.

Kaufman MW, Marti JR, Gallager HS, et al. Carcinoma of the breast with pseudosarcomatous metaplasia.Cancer. 1984;53:1908-17.

Schitt SJ, Millis RR, Hanby AM, Oberman HA. The breast. Chapter 9 in Sternberg's Diagnostic Surgical Pathology. vol 1. Lippincott: W&W; 2004:365-366.

Clark GM. Prognostic and predictive factors. In: Harris JR, Lippman ME, Morrow M, Hellman S, editors. ‘Disease of the Breast’. Philadelphia: Lippincott-Raven publishers; 1996:461-485.

Chao TC, Wang CS, Chen SC, Chen MF. Metaplastic carcinomas of the breast. J Surg Oncol. 1999;71:220-5.

Chhieng C, Cranor M, Lesser ME, Rosen PP. Metaplastic carcinoma of the breast with osteocartilaginous heterologous elements. Am J Surg Pathol. 1998;22:188-94.

Callery CD, Rosen PP, Kinne DW. Sarcoma of the breast. A study of 32 patients with reappraisal of classification and therapy. Ann Surg. 1985;201:527-32.

Pitts WC, Rojas VA, Gaffey MG, Rouse RV, Esteban J, Frierson HF, et al. Carcinoma with metaplasia and sarcomas of the breast. Am J Clin Pathol. 1991;95:623-32.