DOI: http://dx.doi.org/10.18203/2349-2902.isj20182757

Prospective study on use of antibiotic prophylaxis on operative wound infections in south Indian population

Chakarala Obula Reddy, Garisa Chandra Mohana Reddy

Abstract


Background: Antibiotic prophylaxis can help to reduce surgical site infections in operative wound infections. Present work was done to study the use of antibiotic prophylaxis on operative wound infection.

Methods: A total of 120 patients under went various surgeries in the department of surgery, Fathima Institute of Medical Sciences, Kadapa, Andhra Pradesh utilized for the present study. Out of 120 patients utilized 86 were males and 34 females with elective surgeries and observed from their admission to discharge from the hospital and also followed up all the patients up to fifth week of post-surgery. Surgical wound types were observed and recorded.

Results: We have noted clean wound cases were 91, contaminated cases were 5 and clean contaminated were 24 noted. 11 infected cases were observed in clean wound type, 3 infected cases in clean contaminated were observed. 3 patients out of 120 patients had post-operative fever and subsided within 2 days without antibiotics. Out of 91 clean wound cases, 2 patients (2.19%) had post-operative fever, 10 patients (10.9%) developed with serous discharge and purulent discharge was developed in 1 (1.09%) case in present study. Bacteriology revealed 4 cases (4.29%) showed growth of staphylococcus aureus organism, 1 case (1.09%) with pseudomonas organism was noted. 2 cases (8.3%) developed with serous discharge and 1 case (4.16%) with purulent discharge and also growth of E. coli in 1 (4.16%) case was noted in 24 clean contaminated cases in present study.

Conclusions: Use of antibiotic prophylaxis has a vital role in pre and post-operative wound infections.


Keywords


Antibiotics, Infection, Prophylaxis, Wound

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References


Bernier SP, Surette MG. Concentration-dependent activity of antibiotics in natural environments. Front. Microbiol. 2013;4:20.

Onyekwelu I, Yakkanti R, Protzer L, Pinkston CM, Tucker C, Seligson D. Surgical wound classification and surgical site infections in the orthopaedic patient. JAAOS Global Res Rev. 2017 Jun 1;1(3):e022.

Lizán-García M, García-Caballero J, Asensio-Vegas A. Risk factors for surgical wound infection in general surgery a prospective study. Infection Control Hospital Epidemiol. 1997;18:310-5.

Culver DH, Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index. National Nosocomial Infections Surveillance System. Am J Med. 1991 Sep;91(3B):152-7.

Gyssens IC. Preventing postoperative infections. Drugs. 1999 Feb 1;57(2):175-85.

Cummings P, Del Beccaro MA. Antibiotics to prevent infection of simple wounds: a meta-analysis of randomized studies. Am J Emerg Med. 1995;13:396-400.

Grossman JAI, Adams JP, Kunec J. Prophylactic antibiotics in simple hand lacerations. JAMA. 1981;245:1055-6.

Bencini PL, Galimberti M, Signorini M, Crosti C. Antibiotic prophylaxis of wound infections in skin surgery. Arch Dermatol. 1991 Sep;127(9):1357-60.

Bencini PL, Signorini M, Galimberti M, Cavicchini S, Caputo R. Preoperative antibiotic prophylaxis in flexural surgery of difficult contamination-prone areas of the skin: the utility of a single dose of antibiotic. J Dermatologic Treatment. 1994;5:17-9.

Harbarth S, Samore MH, Lichtenberg and D Carmeli Y. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation. 2000;101:2916-21.

Kreter B, Woods M. Antibiotic prophylaxis for cardiothoracic operations. Meta-analysis of thirty years of clinical trials. J Thorac Cardiovasc Surg. 1992;104:590-9.

Paul M, Porat E, Raz A, Madar H, Fein S, Bishara J et al. Duration of antibiotic prophylaxis for cardiac surgery: prospective observational study. J Infect. 2009;58(4):291-8.