Association of the serum-free T3 and T4 hormones in severe traumatic injury

Authors

  • Sarita Ajagallay Department of Surgery, Pt. Jawaharlal Memorial Medical College and Dr. Bheemrao Ambedkar Memorial Hospital, Raipur, Chhattisgarh, India
  • Shobita K. Mane Department of Surgery, Pt. Jawaharlal Memorial Medical College and Dr. Bheemrao Ambedkar Memorial Hospital, Raipur, Chhattisgarh, India
  • Gambheer Singh Department of Surgery, Pt. Jawaharlal Memorial Medical College and Dr. Bheemrao Ambedkar Memorial Hospital, Raipur, Chhattisgarh, India

DOI:

https://doi.org/10.18203/2349-2902.isj20182221

Keywords:

Free T3, Free T4 Hormone, Severe traumatic injury

Abstract

Background: The main objective of the current study to investigate that the association of serum-free t3 and t4 hormones in the patient with a severe traumatic injury.

Methods: The study was conducted at the trauma center, the department of general surgery, Pt. J.N.M. Medical College and associated Dr. B.R. Ambedkar Memorial Hospital, Raipur, C.G.  Total 77 participants were concluded in the present study. The patients with head injuries, chest injury and abdominal injury who sustained their trauma within 24hrs of admission, within the age group of patients are 10-82 years were included. Retrospective observational study design applied to the present study.

Results: The free thyroid hormone (ft3 and ft4) at different time interval at admission, at 24hrs and at 5th day was within normal limit. At admission ft3 mean=1.5 pmol/l (sd=0.18), after 24 hrs and 5th day mean ft3 was 1.47 pmol/l (sd= 0.14). The serum-free t4 mean value at admission, at 24hrs and after 5th day was 0.71 pmol/l (sd=0.52).

Conclusions: The deranged fT4 levels have a significant association with the severity of trauma and the role of hormone level prediction of the trauma victims has important mechanisms which remain an unexplored subject. The prediction of the status ft3 level of the patients paves way for exploring the method through which these could be of clinical use for the patient’s management.

References

Di Prima, Jr PA. EMT Paramedic, 1st Ed. Mc Graw Hill. 2009:1;171-281.

WHO. The World Health Organization report. 2004. Available at www.who.int.

WHO. The World Health Organization, Motor cycle-related injuries in children in South-East Asia Region. 2001. Available at http://www.searo.who.int/entity/disabilities_injury_rehabilitation/documents/motorcyclerelatedinjuriesinchildrensear.pdf?ua=1

Jagnoor J, Suraweera W, Keay L, Ivers RQ, Thakur JS, Jha P. Unintentional injury mortality in India, 2005: nationally representative mortality survey of 1.1 million homes. BMC Public Health. 2012 Dec;12(1):487.

Souleyrette RR, Sathisan SK, James DE, Lim ST. GIS for transportation and air quality analysis. InTransportation planning and air quality ASCE. 1991:182-94.

Statistics India, P. National Crime Records Bureau (1997). Available at http://ncrb.gov.in/StatPublications/ADSI/ADSI1997/accidental-deaths-97.pdf.

Chopra IJ, Huang TS, Beredo A, Solomon DH, Teco GN, Mead JF. Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3, 5, 3'-triiodothyronine in sera of patients with nonthyroidal illnesses. J Clin Endocrinol Metab. 1985 Apr 1;60(4):666-72.

Morley JE, Slag MF, Elson MK, Shafer RB. The interpretation of thyroid function tests in hospitalized patients. JAMA. 1983 May 6;249(17):2377-9.

Kaptein EM, Robinson WJ, Grieb DA, Nicoloff JT. Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the low thyroxine state of acute nonthyroidal illnesses: a noncompartmental analysis. J Clin Invest. 1982 Mar 1;69(3):526-35.

Jenkins H, Holman T, Lyon C, Lane B, Stick R, Hutchison C. Nuclei that lack a lamina accumulate karyophilic proteins and assemble a nuclear matrix. Journal of Cell Science. 1993 Sep;106(1):275-85.

Mendel CM, Frost PH, Cavalieri RR. Effect of free fatty acids on the concentration of free thyroxine in human serum: the role of albumin. J Clin Endocrinol Metab. 1986 Dec 1;63(6):1394-9.

Almassi GH, Schowalter T, Nicolosi AC, Aggarwal A, Moritz TE, Henderson WG, et al. Atrial fibrillation after cardiac surgery: a major morbid event?. Annals of surgery. 1997 Oct;226(4):501.

Magnotti L, Xu DZ, Deitch EA. Interruption of mesenteric lymph reduces lung injury following hemorrhagic shock: 115. J Burn Care Res. 1998 Jan 1;19:S192.

Gulliver P, Begg D. Personality factors as predictors of persistent risky driving behavior and crash involvement among young adults. Injury Prevent. 2007 Dec 1;13(6):376-81.

Eustace D, Wei H. The role of driver age and gender in motor vehicle fatal crashes. J Transport Safety Security. 2010 Mar 16;2(1):28-44.

Downloads

Published

2018-05-24

Issue

Section

Original Research Articles