Liver biopsy in gall stone disease: a prospective study in patients undergoing cholecystectomy

Gaurav Patel; Atul Jain; Malwinder Singh; Meenu Garg; Tanweer Karim; Subhajeet Dey

doi:10.18203/2349-2902.isj20175912

Authors

Gaurav Patel Department of Surgery, ESI PGIMSR and Hospital, Basaidarapur, New Delhi, India
Atul Jain Department of Surgery, ESI PGIMSR and Hospital, Basaidarapur, New Delhi, India
Malwinder Singh Department of Surgery, ESI PGIMSR and Hospital, Basaidarapur, New Delhi, India
Meenu Garg Department of Microbiology, LNJP Hospital, New Delhi, India
Tanweer Karim Department of Surgery, ESI PGIMSR and Hospital, Basaidarapur, New Delhi, India
Subhajeet Dey Department of Surgery, ESI PGIMSR and Hospital, Basaidarapur, New Delhi, India

DOI:

https://doi.org/10.18203/2349-2902.isj20175912

Keywords:

Cholelithiasis, Choledocholithiasis, Gall stone disease, Liver histology, Liver biopsy

Abstract

Background: Cholelithiasis has affected mankind since many centuries. It not only affects the biliary tree but also has adverse effects on the hepatic parenchyma, which can get further complicated due to infected bile. Early intervention in these cases not only retards the unwanted effects but also prevents irreversible damage to liver. Aim of study was to see the effect of gallstone disease on liver in patients of GSD (Cholelithiasis, Chronic cholecystitis, CBD Stones).

Methods: All patients being subjected for planned cholecystectomy were taken as subjects irrespective of age, sex and co-morbid conditions.

Results: 90 patients were included in study and they were evaluated for secondary histopathological changes in liver. Abnormal liver histology was seen in 40% of the cases, with portal tract inflammation being the commonest abnormality seen in 24.4% of patients followed by fatty change (17.8%), cholestasis (10%), lobular parenchymal infiltration (8.9%) and one (1.1%) patient had fibrosis. Choledocholithiasis was associated with a greater incidence of positive bile culture (60%) and greater incidence of abnormal liver histology (80%).

Conclusions: Gall stone disease cause significant changes in liver histology and these changes are more common in those patients having long duration of symptoms. In patients of choledocholithiasis incidence of infected bile and liver histology changes are more as compared to cholelithiasis with chronic cholecystitis.

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