The quintessence of breast leiomyosarcoma

Ashwini Kannamma Kalimuthu, Raja Senthil Viswanathan, Ponniah Iyyappan, Kaliyappa C.


Sarcoma of the breast is a rare condition. The biological differences from other primary breast tumours necessitate a corresponding difference in approach to diagnostic and management strategies. The rarity of the condition has made clinicopathological study difficult. Authors report a case of primary leiomyosarcoma in a 40-yr-old-women, with a 15x9 cm bosselated swelling, involving all 4 quadrants of the left breast. Her clinical features, sonography and trucut biopsy were compatible with cystosarcoma phyllodes and she underwent a left mastectomy for the same. Later the histological and imunohistochemical studies established the diagnosis of leiomyosarcoma, grade 2.


Mastectomy, Spindle cell carcinoma, Sarcoma breast

Full Text:



EL M’rabet FZ, El Mesbahi O, El Hassouni K, khalil El Gueddari B. Primary breast leiomyosarcoma: case report and literature review. Health. 2011 Oct 17;3(10):620.

Cameron HM, Hamperl H, Warambo W. Leiomyosarcoma of the breast originating from myothelium (myoepithelium). J Pathol. 1974 Oct;114(2):89-92.

Raj SD, Sweetwood K, Kapoor MM, Raj KM, Nagi C, Sepulveda KA, Sedgwick EL. Spindle cell lesions of the breast: Multimodality imaging and clinical differentiation of pathologically similar neoplasms. European J Radiol. 2017 May;90:60-72.

Kim BR, Lee JH, Cho E, Kim DC, Park YM, Ha D-H, et al. Primary breast leiomyosarcoma located in the premammary zone: a case report. Clin Imaging. 2015;39:1105-7.

Munitiz V, Rios A, Canovas J, Ferri B, Sola J, Canovas P, et al. Primitive leiomyosarcoma of the breast: case report and review of the literature. Breast. 2004;13:72-6.

Shinto O, Yashiro M, Yamada N, Matsuoka T, Ohira M, Ishikawa T, et al. Primary leiomyosarcoma of the breast: report of a case. Surg Today 2002;32:716-9.

Amaadour L, Benbrahim Z, Moumna K, Boudahna L, Amarti A, Arifi S, et al. Primary breast leiomyosarcoma. Case Rep Oncol Med. 2013;2013:732.

Pardo-MindÁn J, Garcia-Julian G, Altuna ME. Leiomyosarcoma of the breast: Report of a case. Am J Clin Pathol. 1974 Oct 1;62(4):477-80.

De la Pena J, Wapnir I. Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report. Cases J. 2008 Dec;1(1):301.

Adem C, Reynolds C, Ingle JN, Nascimento AG. Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. Br J Cancer. 2004 Jun 8;91(2):237-41.

Pandey M, Mathew A, Abraham EK, Rajan B. Primary sarcoma of the breast. J Surgical Oncol. 2004 Sep 1;87(3):121-5.

Fujita N, Kimura R, Yamamura J, Akazawa K, Kasugai T, Tsukamoto F. Leiomyosarcoma of the breast: a case report and review of the literature about therapeutic management. Breast. 2011 Oct 1;20(5):389-93.

Arista-Nasr J, Gonzalez-Gomez I, Angeles-Angeles A, Illanes-Baz E, Brandt-Brandt H, Larriva-Sahd J. Primary recurrent leiomyosarcoma of the breast: case report with ultrastructural and immunohistochemical study and review of the literature. Am J Clinical Pathol. 1989 Oct 1;92(4):500-5.

Chen KA, Kuo TT, Hoffmann KD. Leiomyosarcoma of the breast. A case of long survival and late hepatic metastasis. Cancer. 1981 Apr;47(7):1883-6.