Case series on the on the onset of transient hypo-parathyroidism after thyroidectomy
DOI:
https://doi.org/10.18203/2349-2902.isj20175112Keywords:
Post thyroidectomy, Transient hypocalcemiaAbstract
Background: Surgery for thyroid disorders is the common operation in general surgery and total thyroidectomy is widely performed both for carcinoma as well as benign bilateral diseases of the thyroid and the most common complication is transient hypocalcaemia. A preliminary study was conducted to assess the risk factors for transient hypocalcaemia in our hospital.
Methods: This was a prospective observational study conducted from February 2013 to April 2014 at the Mahatma Gandhi Medical College and Research Institute, Pondicherry and have included all patients undergone any type of thyroid surgery with a normal pre-operative serum calcium level. After initial clinical assessment, blood samples were drawn for estimation of thyroid function and serum calcium and albumin. Postoperative hypocalcemia was assessed by eliciting Chovstek’s and Troussea’s sign and biochemically estimating serum calcium and albumin at 6,24, and 24 hours intervals and 1st and 3rd months during follow-up. The risk factors involved are also studied like sex, age, type of thyroidectomy, identification of parathyroid, Identification of recurrent laryngeal nerve and their histology.
Results: A total of 50 patients who underwent thyroidectomy were included in the study. The hypocalcemia occurred in 28% of patients studied showed that 66.7% of patients developed hypocalcemia at 48-72 hours. There was no statistical significance for the parameters of age or gender, benign and malignant conditions of thyroid. The analysis of type surgery performed showed a significant number of patients developing transient hypocalcaemia after near or total thyroidectomy (p-0.002).
Conclusions: The present study, though consisted of a small group of patients has shown that transient hypocalcaemia after near or total thyroidectomy occurs in early post-operative days. Hence, on an average 2-5 days of hospital stay is mandatory. Near total or total thyroidectomy is a risk factor. Early diagnosis and replacement with calcium intra-venous reduce the morbidity and mortality of hypocalcaemia.
Metrics
References
Agarwal G, Aggarwal V. Is total thyroidectomy the surgical procedure of choice for benign multi-nodular goiter? An evidence based review. World J Surg. 2008;32:1.
Bentrem DJ, Rademaker A, Angelos P. Evaluation of serum calcium levels in predicting hyperparathyroidism after total/near-total thyroidectomy or parathyroidectomy. Am Surg. 2001;67:249-51. [PubMed]
Abboud B, Sargi Z, Akkam M, Sleilaty F. Risk factors for post thyroidectomy hypocalcemia. J Am Surg. 2002;195:456-61. [PubMed]
Lindblom P, Westerdahl J, Bergenfelz A. Low parathyroid hormone levels after thyroid surgery: a feasible predictor of hypocalcemia. Surgery. 2002;131:515-20. [PubMed]
Tredici P, Grosso E, Gibelli B, Massaro MA, Arrigoni C, Tradati N. Identification of patients at high risk for hypocalcaemia after total thyroidectomy. Acta Otorhinolaryngol Ital. 2011;31(3):144-8.
Viswanathan KV, Jithnath MR, Viswanathan M. Incidence of Post-Operative Hypocalcaemia after Thyroidectomy. A case control study. Int J Adv Health Sci. 2014;1(5):1-9.
Calo PG, Tatti A, Farris S, Nicilosi A. Length of hospital stay and complications in thyroid surgery: our experience. Chir Ital. 2007:59:149-53.
Randall L, Baldassarre, David C, Chang, Kevin T, Brumund, et al. Predictors of Hypocalcaemia after Thyroidectomy: Results from the Nationwide Inpatient Sample. ISRN Surgery. 2012;2012:838614.
Sosa JA, Mehta PJ, Wang TS, Boudourakis L, Roman SA. A population-based study of outcomes from thyroidectomy in aging Americans: at what cost?. J Am College Surgeons. 2008;206(6):1097-105.
Gann DS, Paone JF. Delayed hypocalcaemia after thyroidectomy for Graves’ Disease is prevented by parathyroid auto transplantation. Ann Surg. 1979;190(4):508-12.
Qasaimeh GR, Al Nemri S, Al Omari AK. Incidental extirpation of the parathyroid glands at thyroid surgery: risk factors and post-operative hypocalcemia. European Archives Oto Rhino Laryngology. 2011;268(7):1047-51.