A comparative study between aloe vera gel dressing and conventional dressing in chronic wounds

Authors

  • Virendra S. Athavale Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, DPU University, Pimpri, Pune, Maharashtra, India
  • Shivmurti N. Khandalkar Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, DPU University, Pimpri, Pune, Maharashtra, India
  • Megha Mahawar Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, DPU University, Pimpri, Pune, Maharashtra, India
  • Iresh Shetty Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, DPU University, Pimpri, Pune, Maharashtra, India
  • Aditya Lad Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, DPU University, Pimpri, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-2902.isj20174510

Keywords:

Aloe vera gel, Chronic non-healing ulcers

Abstract

Background: The aim of this study was to evaluate the effectiveness and rate of healing of Aloe vera gel in treatment of chronic wounds, to compare the effectiveness of Aloe vera gel with conventional dressing (normal saline and povidone iodine) and to assess the percentage reduction of wound healing with Aloe vera gel dressing.

Methods: The study was conducted at Dr. D. Y. Patil Medical College and Hospital, DPU University, for a period of 2 months (from January 2017 to March 2017) and is a prospective and comparative randomized type of study using 50 cases (Group A and Group B, 25 each). The study was approved by the Institute’s Ethics Committee.

Results: Data analysis showed that at the end of 4 weeks, mean surface area in Group A is reduced to 4.58 cm2 from 9.79 cm2 which is higher than that in the control group. Also, the average rate of healing in Aloe vera gel is more than control group. Percentage reduction in ulcer surface area was calculated to be much more in Group A as compared to Group B.

Conclusions: The study concluded that Aloe vera gel is highly effective in treatment of chronic ulcers and stimulates the growth of wound healing. Thus, reducing the hospital stay. Apart from being efficacious in wound healing, Aloe vera gel is safe product. No allergic reactions/infections were associated with Aloe vera gel. Aloe vera gel not only heals faster but is also cost effective.

References

REFERENCES

B. Kahle, H. J. Hermanns, and G. Gallenkemper. “Evidence-based treatment of chronic leg ulcers”. Deutsches Ärzteblatt International 2011;108(14): 231–237.

W. B. van Gent, E. D. Wilschut, and C. Wittens. “Management of venous ulcer disease”. The British Medical Journal 2010; 341(7782):1092–1096.

www.disabled-world.com/artman/publish/aloe-vera.shtml

Lee MJ, Lee OH, Yoon SH, et al. In vitro angiogenic activity of Aloe vera gel on calf pulmonary artery endothelial (CPAE) cells. Arch Pharm Res. 1998;21(3):260-65

Barrantes E, Guinea M. Inhibition of collagenase and metalloproteinases by aloins and aloe gel. Life Sci. 2003;72(7):843-50

Winters WD, Benavides R, Clouse WJ. Effects of aloe extracts on human normal and tumor cells in vitro. Economic Botany. 1981;35:89-95.

Habeeb F, Stables G, Bradbury F, et al. The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. Methods. 2007;42(4):388-93.

Habeeb F, Shakir E, Bradbury F, et al. Screening methods used to determine the anti-microbial properties of Aloe vera inner gel. Methods. 2007;42(4):315-20.

t Hart LA, Nibbering PH, van den Barselaar MT, van Dijk H, van den Berg AJ, Labadie RP. Effects of low molecular constituents from Aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human neutrophils. Int J Immunopharmacol. 1990;12(4):427-34.

Shida T, Yagi A, Nishimura H, Nishioka I. Effect of aloe extract on peripheral phagocytosis in adult bronchial asthma. Planta Med. 1985;51(3):273-75.

Yagi A, Shida T, Nishimura H. Effect of amino acids in Aloe extract on phagocytosis by peripheral neutrophil in adult bronchial asthma. Arerugi. 1987;36(12):1094-101.

Vazquez B, Avila G, Segura D, Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol. 1996;55(1):69-75.

Strickland FM, Darvill A, Albersheim P, Eberhard S, Pauly M, Pelley RP. Inhibition of UV-induced immune suppression and interleukin-10 production by plant oligosaccharides and polysaccharides. Photochem Photobiol. 1999;69(2):141-47.

Byeon SW, Pelley RP, Ullrich SE, Waller TA, Bucana CD, Strickland FM. Aloe barbadensis extracts reduce the production of interleukin-10 after exposure to ultraviolet radiation. J Invest Dermatol. 1998;110(5):811-17.

Womble D, Helderman JH. Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn). Int J Immunopharmacol. 1988;10(8):967-74.

Zhang L, Tizard IR. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacol. 1996;35(2):119-28.

Talmadge J, Chavez J, Jacobs L, et al. Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity. Int Immunopharmacol. 2004;4(14):1757-73.

Ali MI, Shalaby NM, Elgamal MH, Mousa AS. Antifungal effects of different plant extracts and their major components of selected aloe species. Phytother Res. 1999;13(5):401-07.

Rosca-Casian O, Parvu M, Vlase L, Tamas M. Antifungal activity of Aloe vera leaves. Fitoterapia. 2007;78(3):219-22.

J. Massagué, “The transforming growth factor-beta family,” Annual Review of Cell Biology, vol. 6, no. 1, pp. 597–641, 1990

Abdullah KM, Abdullah A, Johnson ML, et al. Effects of Aloe vera on gap junctional intercellular communication and proliferation of human diabetic and nondiabetic skin fibroblasts. J Altern Complement Med. 2003;9(5):711-18.

P. R. Roberts, K. W. Black, J. T. Santamauro, and G. P. Zaloga. “Dietary peptides improve wound healing following surgery”. Nutrition 1998; 14(3): 266–269.

A. Barcroft, A. Myskja, and T. Reynolds. “Aloe Vera: Nature's Silent Healer”. BAAM 2003, New York, NY, USA.

www.ncbi.nlm.nih.gov › NCBI › Literature

Downloads

Published

2017-09-27

Issue

Section

Original Research Articles