Role of FNAC in soft tissue tumors and its histopathological correlation

Authors

  • Veenu Jain Department of Pathology, Integral Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
  • Tarun Agarwal Department of Surgery, Carrier Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2349-2902.isj20173402

Keywords:

Cyto-histo correlation, FNAC, Histopathology, Soft tissue tumours

Abstract

Background: Soft tissue tumours are very rare. They are diagnosed initially by Fine needle aspiration cytology (FNAC). The present study was conducted with the aim to study the acceptability and diagnostic accuracy of cytodiagnosis in soft tissue lesions, to evaluate the reliability of cytodianosis as compared conventional histological paraffin section and to assess nuclear grade in various soft tissue lesions.

Methods: The present study was conducted on 140 patients of soft tissue tumours during the period from August 2002 to July 2003 in the Department of pathology and microbiology, LLRM medical college, Meerut. FNAC was done in 132 cases and histopathology was conducted in 86 cases and correlation of those results was done.

Results: Diagnosis of STT by FNAC was done in 132 cases. In benign tumours maximum number of cases (28) was in the age group of 20-29 years and in malignant tumours maximum number of cases (7) was in the age group of 40-49 years. 110 (83.3%) cases were benign and 22 (16.7%) cases were found to be malignant. Maximum number of STT was observed in trunk followed by limb extremities. Male preponderance was observed in the study. The overall accuracy of the present study was 97.7%. Accuracy for diagnosing benign soft tissue tumours was 100% and for malignant STT was 94.5%. The sensitivity, specificity and predictive value of the present study was 100%, 98.6% and 93.3%.

Conclusions: FNAC plays a very important role in initial diagnosis of soft tissue tumours. It provided acceptable diagnostic accuracy when supported by histopathology.

References

Roy S, Manna AK, Pathak S, Guha D. Evaluation of fine needle aspiration cytology and its correlation with histopathological findings in soft tissue tumours. J Cytol. 2007;24:37-40.

Rekhi B, Gorad BD, Kakade AC, Chinoy R. Scope of FNAC in the diagnosis of soft tissue tumors-a study from a tertiary cancer referral center in India. Cyto J. 2007;4:20.

Tailor HJ, Bhagat VM, Kaptan KBR, Italiya SL, Balar HR, Agarwal MP. Diagnostic accuracy of fine needle aspiration cytology in soft tissue tumors: our institutional experience. Int J Res Med Sci. 2013;1:443-7.

Chatura KR, Katyal A, Hiremath SS. Fine-needle aspiration cytology in soft tissue tumors: How far did we go? J Adv Clin Res Insights. 2015;2:1-5.

Moschetta M, Telegrafo M, Carluccio DA, Jablonska JP, Rella L, Serio G, et al. Comparison between fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) in the diagnosis of breast lesions. G Chir. 2014;35(7-8):171-6.

Maitra A, Ashfaq R, Saboorian MH, Lindberg G, Gokaslan ST. The role of fine-needle aspiration biopsy in the primary diagnosis of mesenchymal lesions: a community hospital-based experience. Cancer. 2000;90:178-85.

Bennert KW, Abdul Karim FW. Fine needle aspiration cytology versus core needle biopsy of soft tissue lesions: a comparison. Acta Cytol. 1994;38:381-4.

Kilpatrick SE, Geisinger KR. Soft tissue sarcomas; The utility and limitations of fine needle aspirations biopsy. Am J Clin Pathol. 1998;110(1):50-68.

Bezabih M. Cytological diagnosis of soft tissue tumors.Pathologe. 2007;368(76):28.

Beg S, Vasenwala SM, Haider N, Ahmad SS, Maheshwari V, Khan M. A comparison of cytological and histopathological findings and role of immunostains in the diagnosis of soft tissue tumors. J Cytol. 2012;29:125-30.

Arul P, Masilamani S. Fine needle aspiration cytology of soft tissue tumors with its histopathological correlation in a rural hospital of South India: A retrospective study. Clin Cancer Invest J. 2016;5(2):146-50.

Pollock RE, Karnell LH, Menek HR, Winchester DP. The National cancer Data Base report on soft tissue asarcoma. Cancer. 1996;78:2247-57.

Kilpatrick SE. Prognostication in soft tissue sarcomas grading versus subtyping or both a comprehensive review of the literature with proposed practical guidelines. Ann Diagn Pathol. 1999;3(1):48-61.

Enzinger FM, Weiss SW. Soft tissue tumors. 3rd ed. St. Louis: CV. Mosby Co.; 1995: 491-508.

Palmer HE, Mukunyadzi P, Culbreth W, Thomas JR. Subgrouping and grading of soft tissue sarcomas by fine needle aspiration cytology. A histopathologic correlation study. Diagn Cytopathol. 2001,24:307-16.

Akerman M, Rydholm A, Persson BM. Aspiration cytology of soft-tissue tumors. The 10-year experience at an orthopedic oncology center. Cytopathol. 2007;18:234-40.

Sapi Z, Antal I, Papai Z, Szendroi M, Mayer A, Jakab K, et al. Diagnosis of soft tissue tumours by fine needle aspiration with combined cytopathology and ancillary techniques. Diagn Cytopathol. 2002;26(4):232-42.

Chalita MC, Matira JM, Alves MT, LangattoFilho A. Non-aspiration fine needle cytology and its correlation in canine skin and soft tissue tumours. Annal Quart Cytol Histol. 2001;23(6):399.

Downloads

Published

2017-07-24

Issue

Section

Original Research Articles