Role of vitamin E in management of mastalgia without a palpable lump
DOI:
https://doi.org/10.18203/2349-2902.isj20163572Keywords:
MDA, Mastalgia without a palpable lump, Numerical pain grading scale, Superoxide dismutase, Vitamin EAbstract
Background: Mastalgia also known as mastodynia/mammodynia/mazoplasia is defined as a dull ache or heaviness in the breast. It is a common and troubling condition occurring in about 60-70% of women at some stage of their lives. Mastalgia without a palpable lump poses a significant problem to the surgeons. Mastalgia can significantly affect the quality of life in some women. The major question that worries the patient is the risk of malignancy. Reassurance plays a key role. This study was done to assess the role of vitamin E in treating mastalgia.
Methods: 700 patients who presented to surgical OPD with chief complaint of mastalgia between August 2013 and August 2015 in a tertiary care hospital were examined. 660 of these patients had a palpable lump. 40 patients who complained of pain in one or both breasts but without a palpable lump were included in the study. Severity of pain was marked on pain grading scale. Biochemical tests for lipid peroxidation i.e., malondialdehyde (MDA) and superoxide dismutase (SOD) which are markers of oxidative stress were assessed on first visit. Women complaining of mastalgia but without a palpable breast lump were treated by administration of vitamin E (cap. evion) 200 mg once daily for 3 months and reassessed both clinically and biochemically.
Results: Women treated by vitamin E for 3 months showed a decrease in severity of pain as measured by numerical pain rating scale. Biochemical analysis showed significant decrease in oxidative stress markers MDA and SOD.
Conclusions: Oxidative stress is the primary cause for mastalgia without a palpable lump. Vitamin E at a dosage of 200 mg once daily for 3months has a significant role in the management of such cases.
References
Bailey and love text book of surgery 24th edition, part 8 chapter 50, Breast; 2004.
Makumbi T, Galukande M, Gakwaya A. Mastalgia: prevalence at a sub-saharanafrican tertiary hospital. Pain research and treatment. Pain Res Treat. 2014:article ID 972726.
Harrison M. Non-cyclical mastalgia: an improved classification and treatment. BJS. 1989;76.
Pruthi S, Wahner-Roedler DL, Torkelson CJ, Cha SS, Thicke LS, Hazelton JH, et al. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Alt Med Review. 2010;15(1):559-67.
Does vitamin E help breast pain? Dr. Gen Gunter Breast K; 2009.
Harper’s illustrated biochemistry 28th edition, Chapter 12: biologic oxidation. 2016.
William’s text book of gynaecology, Chapter 15, section 2: Reproductive endocrinology. 2012.
Meyer EC, Sommers DK, Reitz CJ, Mentis H. vitamin E and benign breast diseases. Surgery. 1990:107:549-51.
Parsay S, Olfati F, Nahidi S. Therapeutic effects of vitamin E on cyclic mastalgia. Breast J. 2009;15(5):510-4.