Chronic Salmonella typhi carrier state: a precursor to gall bladder cancer

Ketan Vagholkar; Amish Pawanarkar; Madhavan Iyengar; Suvarna Vagholkar

doi:10.18203/2349-2902.isj20160734

Authors

Ketan Vagholkar Department of Surgery, D. Y. Patil University School of Medicine, Navi Mumbai-400706, Maharashtra
Amish Pawanarkar Department of Surgery, D. Y. Patil University School of Medicine, Navi Mumbai-400706, Maharashtra
Madhavan Iyengar Department of Surgery, D. Y. Patil University School of Medicine, Navi Mumbai-400706, Maharashtra
Suvarna Vagholkar Department of Surgery, D. Y. Patil University School of Medicine, Navi Mumbai-400706, Maharashtra

DOI:

https://doi.org/10.18203/2349-2902.isj20160734

Keywords:

S. typhi, Typhoid chronic carrier, Gall bladder cance

Abstract

Typhoid fever is one of the commonest infections of the gastrointestinal tract seen in the Indian subcontinent. Association with gall stones can lead to a chronic carrier state. This is a dangerous situation as it can strongly predispose to the development of carcinoma of the gall bladder which is known to have a very poor prognosis. The pathophysiology of this carcinogenic change and its clinical implications are discussed in this paper.