Role of oral doxycycline in the management of conjunctival dehiscence following glaucoma drainage device

Authors

  • Prakrati Gupta Department of Glaucoma, LV Prasad Eye Institute, Vijayawada, Andhra Pradesh, India
  • Srisha Senthil Head of Glaucoma services, KAR campus, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Arjun Srirampur Department of Cornea, LV Prasad Eye Institute, Vijayawada, Andhra Pradesh, India
  • Priya Mittal Department of Glaucoma, LV Prasad Eye Institute, Vijayawada, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2349-2902.isj20172801

Keywords:

Ahmed glaucoma valve, Doxycycline, Glaucoma drainage devices, Penetrating keratoplasty

Abstract

Importance of matrix metalloproteinase inhibitor like Doxycycline in the management of conjunctival dehiscence following glaucoma drainage device. A 50 years old man developed conjunctival retraction after a glaucoma grainage device with was managed with oral doxycycline. After 4 month of continuous treatment there was complete healing of conjunctival defect. Oral doxycycline is a viable alternative in the conservative management of conjunctival retraction obviating the need for surgical intervention.

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References

Chan JE, Netland PA. Ex-press glaucoma filtration device: efficacy, safety, and predictability. Med Devices (Auckl). 2015;8:381-8.

Parihar JK, Vats DP, Maggon R, Mathur V, Singh A, Mishra SK. The efficacy of Ahmed glaucoma valve drainage devices in cases of adult refractory glaucoma in Indian eyes. Indian J Ophthalmol. 2009;57(5):345-50.

Geffen N, Buys YM, Smith M, Anraku A, Alasbali T, Rachmiel R, et al. Conjunctival complications related to Ahmed glaucoma valve insertion. J Glaucoma. 2014;23:109-14.

Smith VA, Cook SD. Doxycycline-a role in ocular surface repair. Br J Ophthalmol. 2004;88:619-25.

Wong TT, Sethi C, Daniels JT, Limb GA, Murphy G, Khaw PT. Matrix metalloproteinases in disease and repair processes in the anterior segment. Surv Ophthalmol. 2002;47:239-56.

Dursun D1, Kim MC, Solomon A, Pflugfelder SC. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteina. Am J Ophthalmol. 2001;132(1):8-13.

Garrana RM, Zieske MA, Assouline M, Gipson IK. Matrix metalloproteinases in epithelia from human recurrent corneal erosion. Invest Ophthalmol Vis Sci. 1999;40:1266-70.

Solomon A1, Rosenblatt M, Li DQ, Liu Z, Monroy D, Ji Z, Lokeshwar BL, et al. Doxycycline inhibition of interleukin-1 in the corneal epithelium. Invest Ophthalmol Vis Sci. 2000;41:2544-57.

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Published

2017-06-22

How to Cite

Gupta, P., Senthil, S., Srirampur, A., & Mittal, P. (2017). Role of oral doxycycline in the management of conjunctival dehiscence following glaucoma drainage device. International Surgery Journal, 4(7), 2369–2371. https://doi.org/10.18203/2349-2902.isj20172801

Issue

Section

Case Reports