Acromegaly with negative immunostaining for growth hormone on the contrary to silent somatotroph tumor

Authors

  • Hatice Ozisik Department of Endocrinology and Metabolism, Ege, University, İzmir, Turkey
  • Banu Sarer Yurekli Department of Endocrinology and Metabolism, Ege, University, İzmir, Turkey
  • Nilufer Ozdemir Kutbay Department of Endocrinology and Metabolism, Ege, University, İzmir, Turkey
  • Ilker Altun Department of Endocrinology and Metabolism, Ege, University, İzmir, Turkey
  • Yesim Ertan Department of Pathology, Ege, University, İzmir, Turkey
  • Fusun Saygılı Department of Endocrinology and Metabolism, Ege, University, İzmir, Turkey

DOI:

https://doi.org/10.18203/2349-2902.isj20171174

Abstract

Silent somatotropinomas are not rare. On the contrary to that, the absence of GH immunostaining in acromegaly has not been well defined. So, we would like to to draw the clinician’s attention to such an entity through a case of acromegaly with negative GH staining.

References

Chinezu L, Vasiljevic A, Trouillas J, Lapoirie M, Jouanneau E, Raverot G. Silent somatotroph tumour revisited from a study of 80 patients with and without acromegaly and a review of the literature. Eur J Endocrinol. 2017;176(2):195-201.

Sidhaye A, Burger P, Rigamonti D, Salvatori R. Giant somatotropinoma without acromegalic features: more “quiet” than “silent”: case report. Neurosurgery. 2005;56(5): E1154

Baldeweg SE, Pollock JR, Powell M, Ahlquist J. A spectrum of behaviour in silent corticotrophpituitary adenomas. Br J Neurosurg 2005;19:38-42.

Schroeder JL, Spiotta AM, Fleseriu M, Prayson RA, Hamrahian AH, Weil RJ. Absence of immunostaining for growth hormone in a subset of patients with acromegaly. Pituitary 2014;17:103-8.

Lloyd RV, Cano M, Chandler WF, Barkan AL, Horvath E, Kovacs K. Human growth hormone and prolactin secreting pituitary adenomas by in situhybridization.Am J Pathol. 1989;134:605-13.

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Published

2017-03-25

Issue

Section

Letter to the Editor