Gastric cancer in young patients under the age of 35 years:a hospital based study
Keywords:Gastric cancer, Clinical characteristics and treatments
Background: Over the last decade the incidence rate of gastric cancer in young patients has a trend towards a gradual increase. Our aim was to examine the characteristics of clinical development as well as anatomo-morphologic characteristics of the tumour and to evaluate the results of multimodal treatment of gastric cancer in young patients.
Methods: A total of 163 patients record were available for the study. Patient with diagnosis of gastric cancer were evaluated in term of age, sex, race and symptoms. We only employed descriptive statistical methods in statistical analysis with central tendency and dispersion measurements. Survival curves were estimated using the Kaplan-Meier method, and the log-rank test was utilized to compare survival data.
Results: In the observed group of 28 young gastric cancer patients under the age of 35, with an age range of 20-35 years male to female ratio was 1.3:1. So, for young adults under the age of 35, male population is more predisposed to gastric cancer than female. In all cases the diagnosis was confirmed by histological tests. Glandular and poorly differentiated forms of gastric cancer were prevailing.Conclusions: This present study concludes that pathophysiological process, such as environmental factors and dietary; may interact with genetic factors. A close association has been observed between diffuse gastric cancer and family history in a younger generation of young patients.
Yada T, Yokoi C, Uemura N. The current state of diagnosis and treatment for early gastric cancer. Diagn Ther Endosc. 2013;2013:1-9.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893-917.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.
Nagini S. Carcinoma of the stomach: a review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol. 2012;4:156-69.
Parkin D, Whelan S, Ferlay W, Teppo L, Thomas D. Cancer incidence in five continents. Volume VIII. IARC Sci Publ. 2002;155:1-781.
Okeanov AE, Moiseyev PI, Levin LF. Statistics of cancer diseases in the Republic of Belarus (2004-2013) Edited by Sukonko OG N. N. Alexandrov National Cancer Centre of Belarus. 2014;69-75.
Shah MA, Kelsen DP. Gastric cancer: a primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease. J Natl Compr Canc Netw. 2010;8:437-47.
Merrill RM, Sloan A, Anderson AE, Ryker K. Unstaged cancer in the United States: a population-based study. BMC Cancer. 2011;11:402.
Babak O, Protas Yu. Chronic atrophic gastritis-point reference starts carcinogenesis. Modern Gastroenterol. 2005;5:9-14.
Al-Refaie WB, Hu CY, Pisters PW, Chang GJ. Gastric adenocarcinoma in young patients: a population-based appraisal. Ann Surg Oncol. 2011;18:2800-7.
Buffart TE, Carvalho B, Hopmans E, Brehm V, Kranenbarg EK. Gastric cancers in young and elderly patients show different genomic profiles. J Pathol. 2007;211:45-51.
Lopez-Basave HN, Morales-Vasquez F, Ruiz-Molina JM, Namendys-Silva SA, Vela-Sarmiento I, et al. Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis? Cancer Manag Res. 2013;5:31-6.
Park YK, Kim JC, Koh YS, Joo JK, Ryu SY. Early gastric carcinoma in young patients. Int Surg. 2006;91:316-9.
Isobe T, Hashimoto K, Kizaki J, Miyagi M, Aoyagi K, et al. Characteristics and prognosis of gastric cancer in young patients. Oncol Rep. 2013;30:43-9.
Gunderson LL, Donohue JH, Burch PA. Stomach. In: Abeloff MD. Clinical oncology. 2d Ed. New York, N.Y: Churchill Livingstone; 2000:1545-1579.
Rustgi AK. Neoplasms of the stomach. In: Cecil RL, Goldman L, Bennett JC. Cecil Textbook of Medicine. 21st ed. Philadelphia, Pa.: W.B. Saunders; 2000:738-741.
Bedikian AY, Khankhanian N, Heilbrun LK, Bodey GP, Stroehlein JR, Valdivieso M. Gastric carcinoma in young adults. South Med J. 1979;72:654-6.
Jussawalla DJ, Yeole BB, Natekar MV. Cancer in Indian Moslems. Cancer. 1985;55:1147-58.
Paymaster JC, Gangadharan P. Cancer in the Parsi community of Bombay. Int J Cancer. 1970;5:426-31.
Paymaster JC, Potdar GG, DeSouza LJ, Gangadharan P. Cancer of the stomach. Indian J Cancer. 1973;10:1-14.
Smith BR, Stabile BE. Extreme aggressiveness and lethality of gastric adenocarcinoma in the very young. Arch Surg. 2009;144:506-10.