Acute duodenal diverticulitis with contained perforation causing biliary obstruction and ascending cholangitis: a case report
DOI:
https://doi.org/10.18203/2349-2902.isj20260736Keywords:
Periampullary duodenal diverticulum, Duodenal diverticulitis, Cholangitis, Choledocholithiasis, Lemmel syndrome, Endoscopic retrograde cholangiopancreatographyAbstract
Periampullary duodenal diverticula (PAD) are common in older adults but rarely cause biliary obstruction and cholangitis. Distinguishing diverticulitis with contained perforation from other periampullary pathology can be challenging, and endoscopic visualisation may be limited by scope choice. An 83-year-old woman presented with two weeks of right upper-quadrant pain, associated with fever, jaundice and cholestatic derangement. CT and MRCP showed periampullary diverticulitis with contained perforation, causing common bile duct (CBD) obstruction; several small non‑obstructive CBD stones were also present. She met accepted criteria for definite acute cholangitis. In view of suspected diverticular perforation and anticipated technical challenges with endoscopic retrograde cholangiopancreatography (ERCP), she was managed conservatively with intravenous antibiotics and supportive care, with clinical and biochemical resolution. Follow-up CT intravenous cholangiogram showed normal calibre ducts and no filling defects. Forward-viewing gastroscopy later did not visualise diverticulum. PAD can present with diverticulitis and peridiverticular collection causing biliary obstruction and cholangitis, even when small non‑occlusive CBD stones coexist. Conservative management may be effective in selected stable patients when ERCP carries high risk and side‑viewing duodenoscopy should be considered when endoscopic visualisation is required.
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References
Oukachbi N, Brouzes S. Management of complicated duodenal diverticula. J Visc Surg. 2013;150(3):173-9. DOI: https://doi.org/10.1016/j.jviscsurg.2013.04.006
Gao AR, Matta A, Seth R, Bande D. Lemmel's Syndrome Secondary to Common Bile Duct Compression by an Inflamed Duodenal Diverticulum. Cureus. 2021;13(8):e16959. DOI: https://doi.org/10.7759/cureus.16959
Bakula B, Romic I, Sever M, Halle ZB. Duodenal diverticulum causing obstructive jaundice-Lemmel's syndrome. Rev Esp Enferm Dig. 2021;113(5):375-7. DOI: https://doi.org/10.17235/reed.2020.7516/2020
Rojas RA, Reyes MC, Peñaherrera MV, Gualacata EV, Morillo G, Villacres OP. Lemmel's syndrome: Presentation of an uncommon cholangitis cause and a risk factor for failed endoscopic retrograde cholangiopancreatography. Case report. Int J Surg Case Rep. 2022;90:106698. DOI: https://doi.org/10.1016/j.ijscr.2021.106698
Volpe A, Risi C, Erra M, Cioffi A, Casella V, Fenza G. Lemmel's syndrome due to giant periampullary diverticulum: report of a case. Radiol Case Rep. 2021;16(12):3783-6. DOI: https://doi.org/10.1016/j.radcr.2021.08.068
Ren J, Ding J, Su T, Wu S, Chen F, Li J, et al. Evaluation and management of symptomatic duodenal diverticula: a single-center retrospective analysis of 647 patients. Front Surg. 2023;10:1267436. DOI: https://doi.org/10.3389/fsurg.2023.1267436
Chen Q, Zhang Y, Tang Z, Yu M, Liu Z, Zhou X, et al. The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography. Arch Med Sci. 2020;17(4):905-914. DOI: https://doi.org/10.5114/aoms.2020.94591
Altonbary AY, Bahgat MH. Endoscopic retrograde cholangiopancreatography in periampullary diverticulum: The challenge of cannulation. World J Gastrointest Endosc. 2016 Mar 25;8(6):282-7. DOI: https://doi.org/10.4253/wjge.v8.i6.282
Shrivastava P, Nagendra V, Varma A, Jose AM. A Rare Presentation of Duodenal Diverticulum Causing Obstructive Jaundice: Lemmel's Syndrome. Cureus. 2023;15(1):e33702. DOI: https://doi.org/10.7759/cureus.33702
Yagnik K, Gaddameedi S, Ravilla J, Chhabria P, Rathod M, Vangala A, et al. Rethinking Right Upper Quadrant (RUQ) Pain: The Role of Lemmel Syndrome in Biliary Obstruction. Cureus. 2024;16(12):e76442. DOI: https://doi.org/10.7759/cureus.76442
Jayaraj M, Mohan BP, Dhindsa BS, Mashiana HS, Radhakrishnan G, Dhir V, et al. Periampullary Diverticula and ERCP Outcomes: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2019;64(5):1364-76. DOI: https://doi.org/10.1007/s10620-018-5314-y
Xia C, Sun L, Peng L, Cui F, Jin Z, Huang H. Factors and techniques associated with endoscopic retrograde cholangiopancreatography outcomes in patients with periampullary diverticulum: Results from a large tertiary center. Saudi J Gastroenterol. 2023;29(1):12-20. DOI: https://doi.org/10.4103/sjg.sjg_311_22
Tabak F, Ji GZ, Miao L. Impact of periampullary diverticulum on biliary cannulation and ERCP outcomes: a single-center experience. Surg Endosc. 2021;35(11):5953-61. DOI: https://doi.org/10.1007/s00464-020-08080-8
Sergi W, Libia A, Stasi E, Depalma N, D'Ugo S, Spampinato M. Lemmel's syndrome: Case report of a not feasible endoscopic management. Int J Surg Case Rep. 2024;117:109522. DOI: https://doi.org/10.1016/j.ijscr.2024.109522
Khan F, Chetan MR, D'Costa H. Giant duodenal diverticulum masquerading as a sealed perforation. BJR Case Rep. 2022;8(3):20210196. DOI: https://doi.org/10.1259/bjrcr.20210196
Karagyozov PI, Tishkov I, Boeva I, Draganov K. Endoscopic ultrasound-guided biliary drainage-current status and future perspectives. World J Gastrointest Endosc. 2021;13(12):607-18. DOI: https://doi.org/10.4253/wjge.v13.i12.607
Langdon DE. Side-viewing endoscopy in bleeding duodenal diverticula. Gastrointest Endosc. 1996;44(3):358-9. DOI: https://doi.org/10.1016/S0016-5107(96)70184-0
Baysal C, Saritaş U, Yilmaz U, Kirimlioğlu V, Sahin B. Side-viewing endoscope for diagnosis of bleeding from a duodenal diverticulum. Gastrointest Endosc. 1995;41(5):529. DOI: https://doi.org/10.1016/S0016-5107(05)80027-6