A rare case of colonic metastasis of endometrial adenocarcinoma

Abstract

Colorectal cancer is a leading cause of cancer-related morbidity and mortality, with primary adenocarcinoma of the colon accounting for the majority of cases. Less frequently, metastatic involvement of the colon from other primary malignancies may occur. The authors present the case of a 68-year-old female patient with past history of endometrial adenocarcinoma, who developed a colonic metastasis. The patient was previously treated for endometrioid adenocarcinoma with hysterectomy and bilateral anexectomy and now presented with elevated tumour markers during oncologic follow-up. Imaging revealed a suspicious thickening in the sigmoid colon and endoscopic biopsy confirmed moderately differentiated adenocarcinoma. A laparoscopic sigmoidectomy with liver biopsy was performed, revealing metastatic disease. Immunohistochemistry showed estrogenic and progesterone receptor positivity, as well as other markers suggestive of endometrial adenocarcinoma origin. This case highlights a rare instance of colonic metastasis from endometrial adenocarcinoma, a condition rarely observed in clinical practice. Understanding the histological and immunohistochemical characteristics of both cancers is critical for accurate diagnosis and treatment. This case underscores the importance of considering metastatic diseases when diagnosing colorectal lesions, especially in patients with past history of other malignancies.