Comparison of conventional and ultrasonologically guided fine needle aspiration cytology of the solitary nodule of the thyroid gland

Authors

  • Sajikumar N. R. Department of General Surgery, T.D. Medical College, Alappuzha, Kerala, India
  • Ramkumar V. Department of General Surgery, T.D. Medical College, Alappuzha, Kerala, India

DOI:

https://doi.org/10.18203/2349-2902.isj20171464

Keywords:

Fine needle aspiration cytology, Papillary carcinoma, Thyroid, Ultrasound

Abstract

Background: Solitary nodule of the thyroid can be a manifestation of a diversity of diseases affecting the thyroid gland. FNAC is the initial diagnostic investigation of choice in the work up of such patients. The study aimed to assess the impact of adding ultrasonographic assistance to FNAC in patients with such nodules.

Methods: 100 patients with solitary nodule of thyroid were included in the study. 50 patients each underwent ultrasound guided FNAC and conventional FNAC. The patients proceeded to definitive surgery and the histopathological report was compared to the FNAC report.

Results: The sensitivity (90.0 % v/s 83.3 %), negative predictive power (97.6 % v/s 95 %) and accuracy ( 98 % v/s 96%) of USG guided FNAC was higher than that of conventional FNAC. The false positivity rate (10 % v/s 16.7 %) of USG guided FNAC was found to be lower than that of conventional FNAC. These findings, which apparently showcase the advantages of USG guided FNAC, were not proven to be statistically significant.

Conclusions: The database of our retrospective study regarding age and sex incidence, clinicopathological features and therapeutic outcome was comparable to other studies in various literatures.

References

Gandolfi PP, Prisina A, Raffa M, Renda P, Rochetti O, Ruggeri C. The incidence of thyroid carcinoma in multinodular goiter: a retrospective analysis. Acta Biomedica Ateneo Parmense. 2004;75;114-7.

Kilfroy BA, Zheng T, Halford TR, Han X, Ward MH, Sjodin A. International patterns and trends in the thyroid cancer incidence 1973-2002. PMC. 2009;20(5):525-31.

Smith PW, Salomone LJ, Hanks JB. Thyroid. In Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery: The Biological Basis Of Modern Surgical Practice. 19th edition. Elsevier; 2012: 886-923.

Frates MC, Benson CB, Doubilet PM, Kunreuther M, Contreras M, Cibas ES. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. The Journal Clinical Endocrinology Metabolism. 2006;91:3411-7.

Krukowski ZH. The thyroid and parathyroid glands. In Williams NS, Bulstrode CJK, O’Connell PR, eds. Bailey and Love’s Short practice of Surgery. 26th Edition. CRC Press, Taylor and Francis Group;2013:741-77.

Khan SA, Gafur MA, Khan MK, Karim MR, Mohiuddin M, Islam MS. Pattern of malignancy in clinically solitary thyroid nodule. Mymensingh Med J. 2012;21:1-7.

Khadilkar UN, Maji P. Histopathological study of solitary nodules of thyroid. Kathmandu University Medical Journal. 2008;24:486-90.

Kessler A, Gavriel H, Zahav S, Vaiman M, Shlamkovitch N, Segal S, Eviatar E. Accuracy and consistency of fine-needle aspiration biopsy in the diagnosis and management of solitary thyroid nodules. Israel Medical Association J. 2005;7:371-3.

Kwak JV, Koo H, Kim MJ, Moon HJ, Son EJ. Value of US correlation of a thyroid nodule with initially benign, cytologic results. Radiology. 2010;254:292-300.

Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Revised American Thyroid. Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167-214.

Chaudhary V, Bano S. Imaging of the thyroid: Recent advances. Indian J Endocrinology Metabolism. 2012;16(3):371-6.

Moon JW, Baek JH, Jung SL, Kim DW, Kim EK, Kim JY. Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean J Radiology. 2011;12(1):1-14.

Cai XJ, Valiyaparambath N, Nixon P, Waghorn A, Giles T. Ultrasound guided fine needle aspiration cytology in the diagnosis and management of thyroid nodules. Cytopathology. 2006;17(5):251-6.

Solymosi T, Toth GL, Bodo M. Diagnostic accuracy of fine needle aspiration cytology of the thyroid: Impact of ultrasonography and ultrasonographically guided aspiration. Acta Cytologica. 2001;45:669-74.

Downloads

Published

2017-04-22

Issue

Section

Original Research Articles