Clear cell myoepithelioma of the palate: a case report and comprehensive review

Venkatesh Anehosur; Divya B. Kotian; Jawahar Anand; Kiran Kumar; Niranjan Kumar

doi:10.18203/2349-2902.isj20253051

Authors

Venkatesh Anehosur Department of Oral and Maxillofacial Surgery, SDM Craniofacial Surgery and Research Centre, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad, Karnataka, India
Divya B. Kotian Department of Oral and Maxillofacial Surgery, SDM Craniofacial Surgery and Research Centre, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad, Karnataka, India
Jawahar Anand Department of Oral and Maxillofacial Surgery, SDM Craniofacial Surgery and Research Centre, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad, Karnataka, India
Kiran Kumar Department of Oral and Maxillofacial Surgery, SDM Craniofacial Surgery and Research Centre, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University, Dharwad, Karnataka, India
Niranjan Kumar SDM Craniofacial Centre, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India

DOI:

https://doi.org/10.18203/2349-2902.isj20253051

Keywords:

Myoepithelioma, Hard palate, Salivary gland tumors, Clear cell, Rare

Abstract

Myoepitheliomas are a group of rare tumors of the salivary glands, primarily affecting the parotid gland. It accounts for less than 1% of all salivary gland tumors. The diagnosis of tumors of myoepithelial origin relies on evaluating the histologic features and is confirmed using immunohistochemical analysis. Vimentin and S-100 are non-specific but sensitive immunohistochemical markers of neoplastic myoepithelium. This is a unique case of a clear cell myoepithelioma of the hard palate. Diagnosis involved thorough histological examination and immunohistochemical confirmation, utilizing standard protocols. Our case showcases a rare occurrence of myoepithelioma, specifically the clear cell variant, in the hard palate. Histological analysis revealed large polyhedral cells with eosinophilic and clear cytoplasm and round to oval vesicular nucleus with small nucleoli. The cystic/ pseudo glandular spaces were filled with mucinous material. The results were further validated by immunohistochemical tests using Vimentin and S-100. This case highlights unusual presentation of myoepithelioma outside the parotid gland, emphasizing the importance of considering these tumors as differential diagnosis. Awareness of these atypical manifestations is crucial for accurate diagnosis and optimal patient management.

Metrics

Metrics Loading ...

References

Nair BJ, Vivek V, Sivakumar TT, Joseph AP, Varun BR, Mony V. Clear cell myoepithelioma of the palate with emphasis on clinical and histological differential diagnosis. Clin Pract. 2014;4(1):17-21. DOI: https://doi.org/10.4081/cp.2014.628

Yogee A, Choudhary R, Mathur N, Bhuie H. Myoepithelioma of Soft Palate: A Case Report and Review of Literature. Otorhinolaryngol Clin An Int J. 2016;8(1):32-4. DOI: https://doi.org/10.5005/jp-journals-10003-1222

Hunt KT, Stevens MR, Abdelsayed RA, Nguyen CT. Benign myoepithelioma of the floor of mouth with mandibular involvement: a case report and literature review. J Oral Maxillofac Surg. 2011;69(12):3001-5. DOI: https://doi.org/10.1016/j.joms.2010.12.034

Dardick I, Thomas MJ, van Nostrand AP. Myoepithelioma-new concepts of histology and classification: a light and electron microscopic study. Ultrastructural Pathol. 1989;13(2-3):187-224. DOI: https://doi.org/10.3109/01913128909057442

Hornick JL, Fletcher CD. Myoepithelial tumours of soft tissue: a clinicopathologic and immune-histochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol. 2003;27(9):1183-96. DOI: https://doi.org/10.1097/00000478-200309000-00001

Batsakis JG, Kraemer B, Sciubba JJ. The pathology of head and neck tumors: the myoepithelial cell and its participation in salivary gland neoplasia, Part 17. Head Neck Surg. 1983;5(3):222-33. DOI: https://doi.org/10.1002/hed.2890050307

Luna MA, Mackay B, Gamez-Araujo J. Myoepithelioma of the palate. Report of a case with histochemical and electron microscopic observations. Cancer. 1973;32(6):1429-35. DOI: https://doi.org/10.1002/1097-0142(197312)32:6<1429::AID-CNCR2820320621>3.0.CO;2-7

Sciubba JJ, Brannon RB. Myoepithelioma of salivary glands: report of 23 cases. Cancer. 1982;49(3):562-72. DOI: https://doi.org/10.1002/1097-0142(19820201)49:3<562::AID-CNCR2820490328>3.0.CO;2-6

Barnes L, Appel BN, Perez H, Moneim El‐Attar A. Myoepitheliomas of the head and neck: case report and review. J Surg Oncol. 1985;28(1):21-8. DOI: https://doi.org/10.1002/jso.2930280107

Gnepp DR. Mucinous myoepithelioma, a recently described new myoepithelioma variant. Head Neck Pathol. 2013;7(1):85-9. DOI: https://doi.org/10.1007/s12105-013-0464-x

Ferri E, Pavon I, Armato E, Cavaleri S, Capuzzo P, Ianniello F. Myoepithelioma of a minor salivary gland of the cheek: case report. Acta Otorhinolaryngologica Italica. 2006;26(1):43.

Caldeira PC, Ribeiro DC, de Almeida OP, Mesquita RA, do Carmo MA. Tumor of the hard palate. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(6):722-7. DOI: https://doi.org/10.1016/j.oooo.2011.09.017

Ding J, Wang W, Peng W, Zhou X, Chen T. MRI and CT imaging characteristics of myoepithelioma of the parotid gland. Acta Radiologica. 2016;57(7):837-43. DOI: https://doi.org/10.1177/0284185115609364