Association between fingerprint patterns and prostate cancer grade among blacks: a cross-sectional review

Joseph A. Abiahu; Dudem E. Orakwe; Conellius O. Onuigbo; Onyekachi A. Onu; Timothy U. Mbaeri; Felix E. Menkiti; Vitalis O. Ofuru

doi:10.18203/2349-2902.isj20253007

Authors

Joseph A. Abiahu Department of Surgery, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria
Dudem E. Orakwe Department of Surgery, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria
Conellius O. Onuigbo Department of Surgery, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria
Onyekachi A. Onu Department of Surgery, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria
Timothy U. Mbaeri Department of Surgery, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria
Felix E. Menkiti Department of Anatomic Pathology and Forensic Medicine, Faculty of Basic Clinical Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria
Vitalis O. Ofuru Department of Surgery, Faculty of Clinical Sciences, Rivers State University, Nigeria

DOI:

https://doi.org/10.18203/2349-2902.isj20253007

Keywords:

Prostate cancer, African blacks, Dermatoglyphics, Tumor genetics

Abstract

Background: Prostate cancer is a major global health concern, with higher incidence and aggressiveness among Black men. Owing to its genetic basis, numerous biomarkers have been explored for early detection and prognosis. Simple, low-cost, and less invasive tools are particularly valuable for African populations. Fingerprints, which are genetically determined and unique to individuals, have been investigated as a potential marker for prostate cancer risk. Objective of the study was to examine fingerprint pattern prevalence among Nigerian men with prostate cancer and assess associations with histological grades.

Methods: A descriptive cross-sectional study was conducted from January 2012 to July 2023 among 52 newly diagnosed patients. Fingerprints were captured using a digital reader, standardized, analyzed, and classified. Statistical analysis (Chi-square test) was performed using statistical package for social science (SPSS) v19.0, with significance set at p<0.05.

Results: Loop and composite patterns each accounted for 34.6%, while whorl and arch patterns represented 23.1% and 7.7%, respectively. Among loop patterns, 55.5% were high-grade (ISUP 4 or 5). Composite patterns showed majority (33.3%) ISUP 4, with the highest proportion (83.3%) in loop + arch composites. Whorl patterns were more frequent in low-grade (ISUP 1) disease (41.7%). No statistically significant association was found between fingerprint patterns and ISUP grades (χ²=13.868, p=0.309).

Conclusion: Loop patterns were most frequent, particularly in high-grade disease, but lacked statistical significance as a predictor. Larger, multicenter studies are needed to clarify potential links between dermatoglyphics and prostate cancer.

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