Mechanism of Kupffer cells in hepatitis infected by hepatitis B and C virus

Yi-qing Tan; Xi-wen Zhu; Xing Lai; Jian-ping Gong; Qing-gang Yin

doi:10.18203/2349-2902.isj20170844

Authors

Yi-qing Tan Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Xi-wen Zhu Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Xing Lai Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Jian-ping Gong Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Qing-gang Yin Department of Hepatobiliary and Thoracic Surgery, Tongliang District People 's Hospital, Chongqing, China

DOI:

https://doi.org/10.18203/2349-2902.isj20170844

Keywords:

Infection, Inflammation, Immunity, Kupffer cell

Abstract

The infection of hepatitis B virus or hepatitis C virus (HBV / HCV) is the most common cause of the chronic liver disease. Kupffer cells (KCs), the largest number of viscera macrophages, are located in the sinusoid of the hepar and play an extremely significant role in hepatic chronic inflammation after HBV / HCV infection. KCs could affect the secretion of cytokines and the interaction among cells via a variety of signalling pathways and they could regulate the inflammatory response and immune activities as well. The activation of KCs could balance inflammation and anti-inflammation, maintaining the stability of internal environment in vivo. Studies of KCs have the significance of the understanding of pathogenic mechanisms and the access to the treatment of HBV/HCV infection. Meanwhile, such studies might help to delay the development of fibrosis, cirrhosis and even carcinoma of liver after HBV / HCV infection.

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