Efficacy of platelet rich plasma gel vs conventional dressing in chronic non-healing wounds: a randomized controlled trial
DOI:
https://doi.org/10.18203/2349-2902.isj20252280Keywords:
Chronic non-healing wounds, Conventional dressing, Platelet-rich plasma gel, Randomized controlled trial, Wound healingAbstract
Background: Chronic non-healing wounds pose significant clinical and economic challenges. This study evaluates the efficacy of platelet-rich plasma (PRP) gel against conventional dressings in chronic wound management.
Methods: A single-center, open-label randomized controlled trial included 138 patients with chronic wounds (≥3 months duration). Participants were divided into PRP gel (n=69) and conventional dressing (n=69) groups. Outcomes included healing time, wound size reduction, pain scores, complications and follow-up visits.
Results: PRP-treated wounds achieved complete healing faster (60.87% within 5–8 weeks vs. 34.78% in controls, p<0.001) with fewer complications (scarring: 8.70% vs. 36.23%, p<0.001). PRP reduced follow-up visits (mean: 5.94 vs. 33.16, p<0.001). Pain scores were comparable except transient discomfort during PRP application.
Conclusions: PRP gel accelerates healing, minimizes complications and reduces healthcare burden, making it superior to conventional dressings for chronic wounds.
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References
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