Palpebral schwannoma as an uncommon differential diagnosis in solid eyelid lesions

Noemí Porras Gascón; Cristian Notario Andrade; Jimena Celeste Treviño Flores; Oscar Ulises Rosales Martínez; Iván Yahir Paternina González; Brittani Trejo; Dulce Paola Gómez González; Diana Guadalupe González Guzmán

doi:10.18203/2349-2902.isj20251441

Authors

Noemí Porras Gascón Department of Ophthalmology, National Autonomous University of Mexico, School of Medicine, Santa Julia Medical Center, Tizayuca, Hidalgo, Mexico
Cristian Notario Andrade Hospital Médica de Especialidades Siloe, México
Jimena Celeste Treviño Flores Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México
Oscar Ulises Rosales Martínez Hospital General Regional, Vicente Santos Guajardo, IMSS, México
Iván Yahir Paternina González Hospital Español de México, Ciudad de México, México
Brittani Trejo Universidad Latina de México, Celaya, Guanajuato, México
Dulce Paola Gómez González Universidad Regional del Sureste (URSE), Oaxaca, México
Diana Guadalupe González Guzmán Universidad Autónoma de Yucatán, Mérida, Yucatán, México

DOI:

https://doi.org/10.18203/2349-2902.isj20251441

Keywords:

Eyelid tumors, Benign eyelid tumors, Schwannoma, S-100 protein, Eyelid swellings

Abstract

Schwannoma (neurilemmoma) is a rare benign tumor that originates from Schwann cells of peripheral nerves, accounting for approximately 0.1 to 0.7% of eyelid tumors. The occurrence of schwannoma in the eyelid is extremely rare, with very few cases reported in the literature to date. These tumors are typically solitary, asymptomatic, and slow-growing, which can make early diagnosis challenging. Clinically, they present as solid eyelid masses without skin involvement and can be mistaken for other conditions such as inclusion cysts, recurrent chalazia, or other types of tumors. A definitive diagnosis is obtained through histopathological and immunohistochemical studies. The treatment of choice is complete surgical excision, which generally has a favorable prognosis with a low recurrence rate. This case highlights the importance of always considering schwannomas in the differential diagnosis of any solid eyelid lesion.

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