Electrospun nanofibers and their potential in dental applications: an updated review

Fernando Rosas López Portillo; Aurea Elizabeth Valle Urias; Tonantzin González Arredondo; Marco Antonio Quiroz Beltran; Jose Aurelio Cortina Aguilar; Felix Manuel Manjarrez Guerrero; María del Rosario Cázarez Camacho; Karely Rojo López; Alfredo del Rosario Ayala Ham; Ramsés Eduardo Sandoval Castro; Cristhal Duque Urióstegui; Alan I. Valderrama Treviño

doi:10.18203/2349-2902.isj20251413

Authors

Fernando Rosas López Portillo Department of Graduate Clinic of Oral Rehabilitation, Autonomous University of Sinaloa, Mexico
Aurea Elizabeth Valle Urias Department of Teaching Clinic, Autonomous University of Sinaloa, Mexico
Tonantzin González Arredondo Department of Orthodontics, Autonomous University of Sinaloa, Mexico
Marco Antonio Quiroz Beltran Department of Community and Preventive Area, Autonomous University of Sinaloa, Mexico
Jose Aurelio Cortina Aguilar Department of Dental Operative Clinic, Autonomous University of Sinaloa, Mexico
Felix Manuel Manjarrez Guerrero Department of Orthodontics, Autonomous University of Sinaloa, Mexico
María del Rosario Cázarez Camacho Department of Community Dental Clinics, Autonomous University of Sinaloa, Mexico
Karely Rojo López Department of Teaching Clinic, Autonomous University of Sinaloa, Mexico
Alfredo del Rosario Ayala Ham Department of Endodontics, Autonomous University of Sinaloa, Mexico
Ramsés Eduardo Sandoval Castro Department of Endodontics, Autonomous University of Sinaloa, Mexico
Cristhal Duque Urióstegui Department of Orthodontics. NOVA, Mexico City, Mexico
Alan I. Valderrama Treviño Department of Biomedical Research, UNAM, Mexico City, Mexico

DOI:

https://doi.org/10.18203/2349-2902.isj20251413

Keywords:

Electrospinning, Nanofibers, Odontology, Nanotechnology, Tissue engineering

Abstract

The use of Electrospun nanofibers has proven to be an innovative technology with great potential in the field of dentistry, particularly in tissue engineering and the regeneration of oral and dental tissues. Their ability to mimic the extracellular matrix facilitates cell adhesion, nutrient transport, and cell proliferation, optimizing the biological response. However, despite their multiple benefits, some disadvantages have been reported, related to their structural composition or the difficulty in obtaining ultrafine fibers. Direct electrospinning techniques have been proposed to optimize parameters and incorporate biomolecules. The continuous advancement in biomaterials research will enable better clinical applications and the consolidation of dental tissue regeneration.

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References

Bottino MC, Thomas V, Schmidt G, Vohra YK, Chu TM, Kowolik MJ, et al. Recent advances in the development of GTR/GBR membranes for periodontal regeneration--a materials perspective. Dent Mater. 2012;28(7):703-21. DOI: https://doi.org/10.1016/j.dental.2012.04.022

Santos MS, Carvalho MS, Silva JC. Recent advances on electrospun nanofibers for periodontal regeneration. Nanomaterials (Basel). 2023;13(8):1307. DOI: https://doi.org/10.3390/nano13081307

Zhao P, Chen W, Feng Z, Liu Y, Liu P, Xie Y, et al. Electrospun Nanofibers for Periodontal Treatment: A Recent Progress. Int J Nanomed. 2022;17:4137-62. DOI: https://doi.org/10.2147/IJN.S370340

Xue J, Wu T, Dai Y, Xia Y. Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications. Chem Rev. 2019;119(8):5298-415. DOI: https://doi.org/10.1021/acs.chemrev.8b00593

Seo SJ, Kim HW, Lee JH. Electrospun Nanofibers applications in dentistry. J Nanomat. 2016;2016(1):5931946. DOI: https://doi.org/10.1155/2016/5931946

Rasouli R, Barhoum A, Bechelany M, Dufresne A. Nanofibers for biomedical and healthcare applications. Macromol Biosci. 2019;19(2):1800256. DOI: https://doi.org/10.1002/mabi.201800256

Abadi B, Goshtasbi N, Bolourian S, Tahsili J, Adeli-Sardou M, Forootanfar H. Electrospun hybrid nanofibers: Fabrication, characterization, and biomedical applications. Front Bioeng Biotechnol. 2022;10:986975. DOI: https://doi.org/10.3389/fbioe.2022.986975

Villarreal-Gómez LJ, Cornejo-Bravo JM, Vera-Graziano R, Grande D. Electrospinning as a powerful technique for biomedical applications: a critically selected survey. J Biomater Sci Polym Ed. 2016;27(2):157-76. DOI: https://doi.org/10.1080/09205063.2015.1116885

Kalluri L, Duan Y, Janorkar AV. Electrospun polymeric nanofibers for dental applications. J Appl Poly Sci. 2024;141(15):55224. DOI: https://doi.org/10.1002/app.55224

Jin S, Yeung AWK, Zhang C, Tsoi JK. A Bibliometric Analysis of Electrospun Nanofibers for Dentistry. J Funct Biomater. 2022;13(3):90. DOI: https://doi.org/10.3390/jfb13030090

Maran BAV, Jeyachandran S, Kimura M. A review on the electrospinning of polymer nanofibers and its biomedical applications. J Compos Sci. 2024;8(1):32. DOI: https://doi.org/10.3390/jcs8010032

Zafar M, Najeeb S, Khurshid Z, Vazirzadeh M, Zohaib S, Najeeb B, et al. Potential of electrospun nanofibers for biomedical and dental applications. Materials (Basel). 2016;9(2):73. DOI: https://doi.org/10.3390/ma9020073

Meireles AB, Corrêa DK, da Silveira JV, Millás AL, Bittencourt E, de Brito-Melo GE, et al. Trends in polymeric electrospun fibers and their use as oral biomaterials. Exp Biol Med (Maywood). 2018;243(8):665-76. DOI: https://doi.org/10.1177/1535370218770404

Berton F, Porrelli D, Di Lenarda R, Turco G. A Critical Review on the Production of Electrospun Nanofibres for Guided Bone Regeneration in Oral Surgery. Nanomaterials (Basel). 2019;10(1):16. DOI: https://doi.org/10.3390/nano10010016

Liu W, Thomopoulos S, Xia Y. Electrospun nanofibers for regenerative medicine. Adv Healthc Mater. 2012;1(1):10-25. DOI: https://doi.org/10.1002/adhm.201100021