A rare reaction to a common procedure - anaphylactoid reaction to PEG push pad found in breast tissue markers

Authors

  • Faruk Ayvaz Department of Radiology, Princess Alexandra Hospital, Queensland, Australia
  • Nicholas Low Department of Breast and Endocrine Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia
  • Kathleen Taylor Breast Screen Queensland, QEII Hospital, Nathan, Queensland, Australia
  • Ian Bennett Department of Breast and Endocrine Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia
  • Thomas Lloyd Department of Radiology, Princess Alexandra Hospital, Queensland, Australia

DOI:

https://doi.org/10.18203/2349-2902.isj20251542

Keywords:

Polyethylene glycol, Anaphylaxis, Breast, Vacuum assisted biopsy

Abstract

Polyethylene glycol (PEG) is a synthetic polymer used in a multitude of medical and non-medical settings. Allergy to PEG is a rare but potentially life-threatening condition. We report a case of an anaphylactoid reaction to the PEG component of a breast tissue marker and its subsequent removal using a vacuum assisted biopsy device. We believe this is an important case to draw attention to the fact that PEG is an additive in multiple medications and devices and the product information must be carefully reviewed when planning to administer a medication or device in a patient with a known PEG allergy. This case also highlights the use of vacuum assisted excision as an appropriate non-surgical means of intervention in managing this unusual event.

 

Metrics

Metrics Loading ...

References

Bent RK, Faihs V, Tizek L, Biedermann T, Zink A, Brockow K. PEG allergy - A COVID-19 pandemic-made problem? A German perspective. World Allergy Organ J. 2022;15(11):100714. DOI: https://doi.org/10.1016/j.waojou.2022.100714

Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, et al. European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO. Eur J Surg Oncol. 2024;50(1):107292. DOI: https://doi.org/10.1016/j.ejso.2023.107292

BD. SenoMark™ Ultra Breast Tissue Marker specifications, 2024. Available ar: https://www.bd.com/en-in/products-and-solutions/products/product-families/senomark-ultra-breast-tissue-marker. Accessed on 23 March 2025.

Baumann A, Tuerck D, Prabhu S, Dickmann L, Sims J. Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis? Drug Discov Today. 2014;19(10):1623-31. DOI: https://doi.org/10.1016/j.drudis.2014.06.002

Michael Argentieri DK, Christopher N. Schabowsky. Polyethylene glycol Safety Profile. Food and Drug Administration (FDA); 2021.

Bianchi A, Bottau P, Calamelli E, Caimmi S, Crisafulli G, Franceschini F, et al. Hypersensitivity to polyethylene glycol in adults and children: An emerging challenge. Acta Biomed. 2021;92(S7):e2021519.

Gardiner D. Information Request. In: Ayvaz F, editor.: Bard, Queensland Territory Manager, Peripheral Intervention - Biopsy 2024.

Sellaturay P, Nasser S, Ewan P. Polyethylene Glycol-Induced Systemic Allergic Reactions (Anaphylaxis). J Allergy Clin Immunol Pract. 2021;9(2):670-5. DOI: https://doi.org/10.1016/j.jaip.2020.09.029

Mammatome. HydroMARKTM - Breast Biopsy Site Marker: Devicor Medical Products; 2024. Available at: https://www.mammotome.com/us/en/products/breast-biopsy-markers/hydromark#:~:text=The%20hydrogel%20is%20composed%20of%20polyethylene%20glycol%20(PEG). Accessed on 22 March 2025.

Downloads

Published

2025-05-28

How to Cite

Ayvaz, F., Low, N., Taylor, K., Bennett, I., & Lloyd, T. (2025). A rare reaction to a common procedure - anaphylactoid reaction to PEG push pad found in breast tissue markers. International Surgery Journal, 12(6), 1002–1005. https://doi.org/10.18203/2349-2902.isj20251542

Issue

Section

Case Reports