Mixed mullerian tumour presenting as giant uterine mass: a case report and review of literature

Vrushabh R. Doshi; Vijay R. Naik; Bossuet Afonso; Aparna Joshi; Chitralekha A. Nayak

doi:10.18203/2349-2902.isj20250834

Authors

Vrushabh R. Doshi Department of General Medicine, Healthway Hospitals Pvt. Ltd., Old Goa, Goa, India
Vijay R. Naik Department of General Medicine, Healthway Hospitals Pvt. Ltd., Old Goa, Goa, India
Bossuet Afonso Department of General Surgery, Healthway Hospitals Pvt. Ltd., Old Goa, Goa, India https://orcid.org/0009-0005-6323-6605
Aparna Joshi Department of Histopathology, Healthway Hospitals Pvt. Ltd., Old Goa, Goa, India
Chitralekha A. Nayak Department of General Medicine, Healthway Hospitals Pvt. Ltd., Old Goa, Goa, India https://orcid.org/0009-0004-5894-4044

DOI:

https://doi.org/10.18203/2349-2902.isj20250834

Keywords:

Malignant mixed Müllerian tumour, Giant uterine mass, Massive abdominal distension, Carcinosarcoma, Chemotherapy

Abstract

Malignant mixed Müllerian tumors (MMMT) of the uterine corpus, also referred to as uterine carcinosarcomas, are rare and aggressive neoplasms, accounting for only 1–2% of uterine cancers. These tumors exhibit poor prognosis, with a 5-year survival rate of approximately 30% and only 50% being diagnosed at an early stage. Early detection is crucial, and imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) play a critical role in assessing tumor size, metastasis, and infiltration. The standard treatment involves surgical resection combined with platinum-based chemotherapy. Here, we present a rare case of a giant uterine mass in a 67-year-old female, confirmed to be MMMT. The patient underwent surgical debulking followed by chemotherapy, achieving significant resolution as evidenced by imaging. This case highlights the importance of early diagnosis and multimodal treatment in improving outcomes in MMMT.

Metrics

Metrics Loading ...

References

Soslow RA. Mixed müllerian tumors of the female genital tract. Surg Pathol Clinics. 2009;2(4):707–30. DOI: https://doi.org/10.1016/j.path.2009.08.016

Lee TY, Lee C, Choi WJ, Lee JY, Kim HY. Synchronous occurrence of primary malignant mixed müllerian tumor in ovary and uterus. Obstetrics & Gynecol Sci. 2013;56(4):269–9. DOI: https://doi.org/10.5468/ogs.2013.56.4.269

Singh R. Review literature on uterine carcinosarcoma. J Cancer Res Therap. 2014;10(3):461–8. DOI: https://doi.org/10.4103/0973-1482.138197

Loizzi V, Cormio G, Camporeale A, Maddalena Falagario, Mitri PD, Scardigno D, et al. Carcinosarcoma of the ovary: analysis of 13 cases and review of the literature. Oncol. 2011;80(1-2):102–6. DOI: https://doi.org/10.1159/000328794

McCluggage WG. Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas. J of Clin Pathol. 2002;55(5):321–5. DOI: https://doi.org/10.1136/jcp.55.5.321

Tekwani DT, Joshi SR, Pathak S, Nagare M, Bihade A, Kendre D. Malignant mixed mullerian tumor of the uterus: A case report. Ind J Basic Appl Med Res. 2013;3:33–6.

Penson RT, Powell MA, Dizon DS, Chakrabarti A. Clinical features, diagnosis, staging, and treatment of uterine carcinosarcoma. Uptodate. Published. 2016:1-3.

Morgan ED, Okecha T, Yahaya JJ, Othieno E. Malignant mixed mullerian tumor: A case report about a uterine Tumor’s case. International J of Surgery Open. 2022;43:100493–3. DOI: https://doi.org/10.1016/j.ijso.2022.100493

Kundu R, Shastri M, Gupta P, Gupta N, Srinivasan R, Dey P. Effusion cytology of metastatic carcinosarcoma. CytoJournal. 2023;20:14. DOI: https://doi.org/10.25259/Cytojournal_30_2022

Vijayaraghavan N, Ravikumar D. Clinical profile and treatment outcomes of malignant mixed mullerian tumors of the uterus: a single-center experience. Cureus. 2023;1:23. DOI: https://doi.org/10.7759/cureus.48079