Outcome of re-exploration and continuous irrigation with gentamicin-mixed normal saline via tri-channel Foley's catheter in postoperative discitis patients at a tertiary care hospital
DOI:
https://doi.org/10.18203/2349-2902.isj20250557Keywords:
Postoperative discitis, Irrigation, Gentamicin, Normal saline, Tri-channel Foley's catheterAbstract
Background: Discitis, an inflammation of vertebral plates due to infection, can occur post-lumbar discectomy, affecting 0.2–4% of cases. This study assessed outcomes of re-exploration and continuous irrigation with gentamicin-normal saline via a tri-channel Foley catheter for postoperative discitis (POD).
Methods: A retrospective observational study at Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh, analyzed 30 patients with POD post-lumbar disc surgery (March 2020–February 2022).
Results: The mean age was 43.0±12.90 years, with L4/5 being the most affected level (60%). Persistent pain and fever were common (80%), with Staphylococcus aureus identified in 73.33% via blood cultures. Treatment showed significant improvements: erythrocyte sedimentation rate (ESR) reduced from 58.32±18.02 mm to 28.00±4.18 mm, CRP from 68.82±19.82 mg/l to 13.42±3.40 mg/l (both p<0.001), VAS scores from 7.52±1.73 to 1.32±1.59 (p<0.01), and JOA scores across sensory, motor, and activity parameters (p<0.01). Satisfactory outcomes were achieved in 80% of patients, with excellent results in 46.67% and good results in 33.33%.
Conclusions: Continuous irrigation with gentamicin-normal saline was effective in reducing inflammation, improving functionality, and achieving favorable outcomes in the majority of patients.
Metrics
References
Turnbull F. Postoperative inflammatory disease of lumbar discs. J Neurosurg. 1953;10:469-73. DOI: https://doi.org/10.3171/jns.1953.10.5.0469
Onik G. Automated percutaneous biopsy in the diagnosis and treatment of infectious discitis. Neurosurg Clin N Am. 1996;7(1):145-50. DOI: https://doi.org/10.1016/S1042-3680(18)30413-3
Moon MS, Kim SS, Lee BJ, Moon JL, Sihn JC, Moon SI. Pyogenic discitis following discectomy. J Orthop Surg. 2012;20(1):11-7. DOI: https://doi.org/10.1177/230949901202000103
Chen SH, Chen WJ, Wu MH, Liao JC, Fu CJ. Postoperative infection in patients undergoing posterior lumbosacral spinal surgery: a pictorial guide for diagnosis and early treatment. Clin Spine Surg. 2018;31(6):225-38. DOI: https://doi.org/10.1097/BSD.0000000000000633
Osti O, Fraser R, Vernon-Roberts B. Discitis after discography. The role of prophylactic antibiotics. J Bone Joint Surg Br. 1990;72:271. DOI: https://doi.org/10.1302/0301-620X.72B2.2312567
Jain M, Sahu RN, Gantaguru A, Das SS, Tripathy SK, Pattnaik A. Postoperative lumbar pyogenic spondylodiscitis: an institutional review. J Neurosci Rural Pract. 2019;10(3):511-8. DOI: https://doi.org/10.1055/s-0039-1697887
Singh DK, Singh N, Das PK, Malviya D. Management of postoperative discitis: A review of 31 patients. Asian J Neurosurg. 2018;13:703-6. DOI: https://doi.org/10.4103/ajns.AJNS_233_16
Torda AJ, Gottlieb T, Bradbury R. Pyogenic vertebral osteomyelitis: analysis of 20 cases and review. Clin Infect Dis. 1995;20:320-8. DOI: https://doi.org/10.1093/clinids/20.2.320
Rawlings CE, Wilkins RH, Gallis HA, Goldner JL, Francis R. Post-operative intervertebral disc space infection. Neurosurgery. 1983;13:371-5. DOI: https://doi.org/10.1097/00006123-198310000-00004
Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systemic review of clinical characteristics. Semin Arthritis Rheum. 2009;39:10-7. DOI: https://doi.org/10.1016/j.semarthrit.2008.03.002
Santhanam R, Lakshmi K. A retrospective analysis of the management of postoperative discitis: a single institutional experience. Asian Spine J. 2015;9(4):559-64. DOI: https://doi.org/10.4184/asj.2015.9.4.559
Silber JS, Anderson DG, Vaccaro AR, Anderson PA, McCormick P; NASS. Management of postprocedural discitis. Spine J. 2002;2(4):279-87. DOI: https://doi.org/10.1016/S1529-9430(02)00203-6
Hadjipavlou AG, Korovessis PG, Nakavelakis KN. Spine infections: medical versus surgical treatment options. In: Vaccaro AR, Eck JC, editors. Controversies in spine surgery: best evidence recommendations. 1st edition. New York/Stuttgart: Thieme Publishers. 2010;250-60.
Wang J, Yang Y, Lv W, Xu S, Mei S, Shi F, et al. Gentamycin irrigation significantly reduces 28-day surgical site infection after emergency neurosurgery. Br J Neurosurg. 2024;38(2):481-5. DOI: https://doi.org/10.1080/02688697.2021.1902472
Bansal D, Khatri K, Dahuja A, Lakhani A, Malhotra N. Comparison between vancomycin and gentamicin for intraoperative presoaking of hamstring graft in primary anterior cruciate ligament reconstruction. Cureus. 2022;14(2):e22550. DOI: https://doi.org/10.7759/cureus.22550
AbdulWahid AT. Gentamycin injection in disc space during lumbar discectomy (aiming to prevent post-operative discitis). J Fac Med Baghdad. 2015;57(1):15-7. DOI: https://doi.org/10.32007/jfacmedbagdad.571297
Rath SA, Nelf U, Schneider O, Richter HP. Neurosurgical management of thoracic and lumbar osteomyelitis and discitis in adults: a review of 43 conservative surgically treated patients. Neurosurgery. 1996;38:926-33. DOI: https://doi.org/10.1097/00006123-199605000-00013
Rohde V, Meyer, Schaller, Hassier WE. Spondylodiscitis after lumbar discectomy: incidence and a proposed prophylaxis. Spine. 1998;23:615-20. DOI: https://doi.org/10.1097/00007632-199803010-00016
Fouquet B, Ganpille P, Jattit F, Cotty P, Lapierre F, Valat JP, et al. Discitis after lumbar disc surgery: features of septic and aseptic forms. Spine. 1992;17:356-8. DOI: https://doi.org/10.1097/00007632-199203000-00019
Sapkas GS, Mavrogenis AF, Mastrokalos DS, Papadopoulos E, Papagelopoulos EC, Papagelopoulos PJ. Postoperative spine infection: a retrospective analysis of 21 patients. Eur J Orthop Surg Traumatol. 2006;16:322-6. DOI: https://doi.org/10.1007/s00590-006-0090-3
Hopkinson N, Stevenson J, Benjamin S. A case ascertainment study of septic discitis: clinical, microbiological and radiological features. QJM. 2001;94:465-70. DOI: https://doi.org/10.1093/qjmed/94.9.465
Thelander U, Larsson S. Quantization of C-reactive protein level and erythrocyte sedimentation rate after spinal surgery. Spine. 1992;17:400-4. DOI: https://doi.org/10.1097/00007632-199204000-00004
Emile SH, Elfallal AH, Abdel-Razik MA, El-Said M, Elshobaky A. A randomized controlled trial on irrigation of open appendectomy wound with gentamicin-saline solution versus saline solution for prevention of surgical site infection. Int J Surg. 2020;81:140-6. DOI: https://doi.org/10.1016/j.ijsu.2020.07.057
Fatula LK, Nelson A, Abbad H, Ewing JA, Hancock BH, Cobb WS, et al. Antibiotic irrigation of the surgical site decreases incidence of surgical site infection after open ventral hernia repair. Am Surg. 2018;84(7):1146-51. DOI: https://doi.org/10.1177/000313481808400728
Bayer J, Vackova Z, Svecova H, Stirand P, Spicak J, Martinek J. Gentamicin submucosal lavage during peroral endoscopic myotomy (POEM): a retrospective analysis. Surg Endosc. 2018;32(1):300-6. DOI: https://doi.org/10.1007/s00464-017-5677-8
Maaty AM, Yehia AA, Abdelaleem MM, El-Fattah MA. Subcutaneous antibiotic irrigation to prevent wound infection in obese patients undergoing cesarean section. Women Health Care Issues. 2021;4(3):1-5. DOI: https://doi.org/10.31579/2642-9756/060
Yazdi H, Gomrokchi AY, Nazarian A, Lechtig A, Hanna P, Ghorbanhoseini M. The effect of gentamycin in the irrigating solution to prevent joint infection after anterior cruciate ligament (ACL) reconstruction. Arch Bone Jt Surg. 2019;7(1):67-74.
Koutsoumbelis S, Hughes AP, Girardi FP, Cammisa FP Jr, Finerty EA, Nguyen JT, et al. Risk factors for postoperative infection following posterior lumbar instrumented arthrodesis. J Bone Joint Surg Am. 2011;93:1627-33. DOI: https://doi.org/10.2106/JBJS.J.00039
Chahoud J, Kanafani Z, Kanj SS. Surgical site infections following spine surgery: eliminating the controversies in the diagnosis. Front Med (Lausanne). 2014;1:7. DOI: https://doi.org/10.3389/fmed.2014.00007