Management of chemical injury with total corneal scar and cicatrization treated with simple limbal epithelial transplantation and amniotic membrane transplantation: a case report

Authors

  • Sushma Suram Pristyn Care, Bangalore, India
  • Mitesh Mohan Hood AGM-Medical Excellence, Pristyn care, Gurgaon, Haryana, India

DOI:

https://doi.org/10.18203/2349-2902.isj20250589

Keywords:

Chemical injury, Corneal scar, Limbal stem cell deficiency, SLET, AMT, Ocular trauma

Abstract

Chemical injuries to the eye are medical emergencies that can result in severe visual impairment or blindness, especially when complicated by limbal stem cell deficiency (LSCD) and cicatrization. Simple limbal epithelial transplantation (SLET) combined with amniotic membrane transplantation (AMT) has shown promise in treating such conditions, offering a path to restore corneal clarity and function. A 46-year-old male presented with sudden vision loss, redness, and pain in the left eye following a chemical injury. Examination revealed a total corneal scar with cicatrization, and the patient was diagnosed with LSCD. He underwent SLET combined with AMT for corneal restoration. Postoperatively, gradual corneal clarity was observed, and vision improved to counting fingers at 2 meters, though further improvement was limited due to a cataract. This case underscores the potential effectiveness of SLET + AMT in managing severe chemical injuries complicated by LSCD. While partial recovery was achieved, further surgical intervention for cataract removal may be necessary to optimize visual acuity. The case highlights the importance of early diagnosis and timely surgical management in such patients.

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References

Akgun Z, Selver OB. Epidemiology and etiology of chemical ocular injury: A brief review. World J Clin Cases. 2023;11(6):1245-51.

Singh P, Tyagi M, Kumar Y, Gupta KK, Sharma PD. Ocular chemical injuries and their management. Oman J Ophthalmol. 2013;6(2):83-6. DOI: https://doi.org/10.4103/0974-620X.116624

Dua HS, Ting DSJ, Al Saadi A, Said DG. Chemical eye injury: pathophysiology, assessment and management. Eye (Lond). 2020;34(11):2001-19. DOI: https://doi.org/10.1038/s41433-020-1026-6

Mobaraki M, Abbasi R, Omidian Vandchali S, Ghaffari M, Moztarzadeh F, Mozafari M. Corneal Repair and Regeneration: Current Concepts and Future Directions. Front Bioeng Biotechnol. 2019;7:135. DOI: https://doi.org/10.3389/fbioe.2019.00135

Haagdorens M, Van Acker SI, Van Gerwen V, et al. Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies. Stem Cells Int. 2016;1:9798374. DOI: https://doi.org/10.1155/2016/9798374

Sangwan VS, Basu S, MacNeil S, Balasubramanian D. Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency. Br J Ophthalmol. 2012;96(7):931-4. DOI: https://doi.org/10.1136/bjophthalmol-2011-301164

Le Q, Deng SX. The application of human amniotic membrane in the surgical management of limbal stem cell deficiency. Ocul Surf. 2019;17(2):221-9. DOI: https://doi.org/10.1016/j.jtos.2019.01.003

Shanbhag SS, Patel CN, Goyal R, Donthineni PR, Singh V, Basu S. Simple limbal epithelial transplantation (SLET): Review of indications, surgical technique, mechanism, outcomes, limitations, and impact. Indian J Ophthalmol. 2019;67(8):1265-77. DOI: https://doi.org/10.4103/ijo.IJO_117_19

Akgun Z, Selver OB. Epidemiology and etiology of chemical ocular injury: A brief review. World J Clin Cases. 2023;11(6):1245-51. DOI: https://doi.org/10.12998/wjcc.v11.i6.1245

Quesada JM, Lloves JM, Delgado DV. Ocular chemical burns in the workplace: Epidemiological characteristics. Burns. 2020;46(5):1212-8. DOI: https://doi.org/10.1016/j.burns.2019.11.007

Rauchman SH, Locke B, Albert J, De Leon J, Peltier MR, Reiss AB. Toxic External Exposure Leading to Ocular Surface Injury. Vision (Basel). 2023;7(2):32. DOI: https://doi.org/10.3390/vision7020032

Bizrah M, Yusuf A, Ahmad S. An update on chemical eye burns. Eye (Lond). 2019;33(9):1362-77. DOI: https://doi.org/10.1038/s41433-019-0456-5

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Published

2025-02-27

How to Cite

Suram, S., & Hood, M. M. (2025). Management of chemical injury with total corneal scar and cicatrization treated with simple limbal epithelial transplantation and amniotic membrane transplantation: a case report. International Surgery Journal, 12(3), 447–449. https://doi.org/10.18203/2349-2902.isj20250589

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Section

Case Reports