Comparison of quality of life and sexual function before and after anterior urethral reconstruction surgery
DOI:
https://doi.org/10.18203/2349-2902.isj20243550Keywords:
Anterior urethral stricture, IPSS, IIEF-5 and urethral surgeryAbstract
The study assessed the impact of anterior urethral reconstruction surgery on quality of life and sexual function in 22 male patients with anterior urethral strictures. The mean age was 51 years (range: 25–88), and strictures were localized in the bulbar urethra, penile urethra, or both, with an average stricture length of 4.2 cm. Etiologies included trauma, iatrogenic causes, infections, and idiopathic factors. Surgical techniques included end-to-end urethroplasty, dorsal onlay oral mucosa graft urethroplasty, and combined dorsal graft with ventral augmentation. Significant postoperative improvements were noted in urinary symptoms, with IPSS scores reducing from severe to mild in all patients (p<0.001) and Qmax increasing from a mean of 3.23 ml/s to 19.46 ml/s (p<0.001). Preoperative quality of life, evaluated using EQ-5D and EQ-VAS, showed significant enhancement, with EQ-VAS scores improving from 38.77 to 77.05 (p<0.001). Sexual function, assessed via IIEF-5, remained stable, with no significant postoperative decline (p=0.463), highlighting the preservation of erectile function. USS-PROM evaluations revealed a substantial reduction in symptom severity and improved patient satisfaction. The findings demonstrate that anterior urethral reconstruction effectively restores urinary function and improves quality of life without compromising sexual health, establishing it as a safe and reliable treatment for anterior urethral strictures.
References
Mundy AR, Andrich DE. Urethral trauma. Part I: introduction, history, anatomy, pathology, assessment, and emergency management. BJU Int. 2011;108(3):310–27.
Latini JM, McAninch JW, Brandes SB, Chung JY, Rosenstein D. SIU/ICUD consultation on urethral strictures: epidemiology, etiology, anatomy, and nomenclature of urethral stenoses, strictures, and pelvic fracture urethral disruption injuries. Urol. 2014;83(3):1-7.
Palminteri E, Berdondini E, Verze P, De Nunzio C, Vitarelli A, Carmignani L. Contemporary urethral stricture characteristics in the developed world. Urol. 2013;81(1):191–7.
Alwaal A, Blaschko SD, McAninch JW, Breyer BN. Epidemiology of urethral strictures. Transl Androl Urol. 2014;3(2):209–13.
Hughes M, Caza T, Li G, Daugherty M, Blakley S, Nikolavsky D. Histologic characterization of post-radiation urethral stenosis in men treated for prostate cancer. World J Urol. 2020;38(9):2269–77.
Handmer M, Martin J, Tiu A. Costing Urologic Complications Following Pelvic Radiation Therapy. Urology. 2020;140:64–9.
Lumen N. EAU Guidelines on Urethral Strictures. Guidelines EAU. 2024;1:7–108.
Latini JM, McAninch JW, Brandes SB, Chung JY, Rosenstein D. SIU/ICUD consultation on urethral strictures: epidemiology, etiology, anatomy, and nomenclature of urethral stenoses, strictures, and pelvic fracture urethral disruption injuries. Urol. 2014;83(3):1–7.
Lumen N, Hoebeke P, Willemsen P, De Troyer B, Pieters R, Oosterlinck W. Etiology of urethral stricture disease in the 21st Century. J Urol. 2009;182(3):983–7.
Falcone M, Garaffa G, Castiglione F, Ralph DJ. Current management of penile fracture: an up-to-date systematic review. Sex Med Rev. 2018;6(2):253–60.
Barratt RC, Bernard J, Mundy AR, Greenwell TJ. Pelvic fracture urethral injury in males—mechanisms of injury, management options, and outcomes. Transl Androl Urol. 2018;(1):29–62.
Fenton AS, Morey AF, Aviles R, Garcia CR. Anterior urethral strictures: Etiology and characteristics. Urology. 2005;65(6):1055–8.
Cotter KJ, Hahn AE, Voelzke BB, Myers JB, Smith TG, Elliott SP, et al. Trends in urethral stricture disease etiology and urethroplasty technique from a multi-institutional surgical outcomes research group. Urol. 2019;130:167–74.
Stein DM, Thum DJ, Barbagli G, Kulkarni S, Sansalone S, Pardeshi A, et al. A geographic analysis of male urethral stricture aetiology and location. BJU Int. 2013;112(6):830–4.
Wood DN, Nethercliffe J, Andrich DE, Greenwell TJ, Mundy AR. Peritoneal and perineal anatomy and surgical approaches. BJU Int. 2004;94(5):719–37.
Terlecki RP, Steele MC, Valadez C, Morey AF. Grafts are Unnecessary for Proximal Bulbar Reconstruction. J Urol. 2010;184(6):2395–9.
Wessells H, McAninch JW. Current controversies in anterior urethral stricture repair: free-graft versus pedicled skin-flap reconstruction. World J Urol. 1998;16(3):175–80.
Preciado-Estrella D, Sanchez J, Herrera J. Determination of uroflowmetric parameters and their relationship with anthropometric parameters in asymptomatic Mexican men. Rev Mex Urol. 2021;78(2):135–43.
Jørgensen JB, Jensen KME. UROFLOWMETRY. Urologic Clinics of North America. 1996;23(2):237–42.
Lambert E, Denys M, Poelaert F, Everaert K, Lumen N. Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men. Int J Urol. 2018;25(9):792–8.
Robey C, McCammon K, Perry M, Zagade T, Brugh V, Liu J. Inter-rater reliability of retrograde urethrograms. World J Urol. 2023;41(4):1163–7.
Rosenbaum CM, Reiss CP, Borgmann H, Salem J, Fisch M, Huber J, et al. Management of anterior urethral strictures in adults: a survey of contemporary practice in Germany. Urol Int. 2017;99(1):43–50.
Mahmud SM, El KS, Rana AM, Zaidi Z. Is ascending urethrogram mandatory for all urethral strictures? J Pak Med Assoc. 2008;58(8):429–31.
Wessells H, Morey A, Souter L, Rahimi L, Vanni A. Urethral stricture disease guideline amendment. J Urol. 2023;210(1):64–71.
Pisapati VLNM, Paturi S, Bethu S, Jada S, Chilumu R, Devraj R, et al. Dorsal buccal mucosal graft urethroplasty for anterior urethral stricture by ASOPA technique. Eur Urol. 2009;56(1):201–6.
Wessells H, Angermeier KW, Elliott S, Gonzalez CM, Kodama R, Peterson AC, et al. Male Urethral Stricture: American Urological Association Guideline. J Urol. 2017 Jan;197(1):182–90.
Mundy AR. The long-term results of skin inlay urethroplasty. Br J Urol. 1995;75(1):59–61.
Guralnick ML, Webster GD. The augmented anastomotic urethroplasty: indications and outcome in 29 patients. J Urol. 2001 May;165(5):1496–501.
Santucci RA, Mario LA, McAninch JW. Anastomotic urethroplasty for bulbar urethral stricture: analysis of 168 patients. J Urol. 2002;167(4):1715–9.
Baradaran N, Hampson LA, Edwards TC, Voelzke BB, Breyer BN. Patient-Reported Outcome Measures in Urethral Reconstruction. Curr Urol Rep. 2018;19(7):48.
Pang KH, Osman NI, Chapple CR, Eardley I. Erectile and Ejaculatory Function Following Anterior Urethroplasty: A Systematic Review and Meta-analysis. Eur Urol Focus. 2022;8(6):1736–50.
Jackson MJ, Sciberras J, Mangera A, Brett A, Watkin N, N’Dow JMO, et al. Defining a Patient-Reported Outcome Measure for Urethral Stricture Surgery. Eur Urol. 2011;60(1):60–8.
Puche-Sanz I, Martín-Way D, Flores-Martín J, Expósito-Ruiz M, Vicente-Prados J, Nogueras-Ocaña M, et al. Psychometric validation of the Spanish version of the USS-PROM questionnaire for patients undergoing anterior urethral surgery. Actas Urol Esp. 2016;40(5):322–7.
Tam CA, Elliott SP, Voelzke BB, Myers JB, Vanni AJ, Breyer BN, et al. The International Prostate Symptom Score (IPSS) is an inadequate tool to screen for urethral stricture recurrence after anterior urethroplasty. Urology. 2016;95:197–201.
Vallejo-Medina P, Saffon JP, Álvarez-Muelas A. Colombian clinical validation of the international index of erectile function (IIEF-5). Sex Med. 2022;10(1):100461.
Nilsen OJ, Holm HV, Ekerhult TO, Lindqvist K, Grabowska B, Persson B, et al. To transect or not transect: results from the scandinavian urethroplasty study, a multicentre randomised study of bulbar urethroplasty comparing excision and primary anastomosis versus buccal mucosal grafting. Eur Urol. 2022;81(4):375–82.
Surur-Zaibaka E, Bolado-García PB, Gamboa-López GJ, Gómez-Ávalos T, Mena-Ramírez LF. Urethral plasty and quality of life associated with surgical technique in the High Specialty Medical Unit in Mérida. Cir Cir. 2019;86(4):23-8.
Xie H, Xu YM, Xu XL, Sa YL, Wu DL, Zhang XC. Evaluation of erectile function after urethral reconstruction: a prospective study. Asian J Androl. 2009;11(2):209–14.
Kałużny A, Krukowski J, Frankiewicz M, Matuszewski M. The impact of post-urethroplasty erectile dysfunction on the quality of life and treatment satisfaction. Cent European J Urol. 2021;74(1):116–20.
Redmond E, Bekkema J, Rourke K. Comprehensive prospective assessment of patient-reported outcomes following urethroplasty. Urol. 2020;141:162–7.