Randomized controlled study of effectiveness and timings of bupivacaine at port site in managing pain after laparoscopic cholecystectomy
DOI:
https://doi.org/10.18203/2349-2902.isj20162888Keywords:
Bupivacaine, Laparoscopic cholecystectomy, Postop pain, Port siteAbstract
Background: Laparoscopic cholecystectomy now a day is considered a day care procedure, but postoperative pain, requiring injectable analgesics is one of the hurdles in performing it as day care. Aim was to assess the effectiveness of port site instillation of bupivacaine in reduction of post-operative pain after laparoscopic cholecystectomy.
Methods: The study was conducted from November 2013 to November 2015 on 120 patients undergoing elective laparoscopic cholecystectomy at SGRDIMSAR, Sri Amritsar. The study was a randomized controlled in which patients were randomly allocated into 3 groups of 40 patients each. In group 1, pre-incisional local infiltration of the port sites with bupivacaine was done throughout all the layers of the abdominal wall. In group 2, local infiltration of the port sites with bupivacaine was done after the completion of surgical procedure and before the closure of skin. In Group 3 no local infiltration was done. The study was evaluated using Visual analog scale for a period of 24 hours post operatively.
Results: Instillation of bupivacaine at the port sites in laparoscopic cholecystectomy irrespective of the timing of instillation is an effective method of achieving pain control in the post-operative period as long as 24 hours after surgery.
Conclusions: Instillation of bupivacaine at the port sites in laparoscopic cholecystectomy is simple, safe, and without adverse effects and local anesthetics should be considered for instillation in all patients at the beginning and at the end of laparoscopic procedures.
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References
Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Characterisics and prediction of early pain after laparoscopic cholecystectomy. Pain. 2001;90(3):261-9.
Jensen K, Khlet H, Lund CM. Post-operative recovery profile after laparoscopic cholecystectomy: a prospective, observational study of a multimodal anaesthetic regime. Acta Anaesthesiol Scand. 2007;51:464-71
Hazinedaroglu SM, Kayaoglu HA, Ates Y, Ertürk S, Butuner C, Turkcapar AG. Intraperitoneal bupivacaine for postoperative pain relief after laparoscopic cholecystectomy. Pain Med. 2006;7:539-41.
Pavlin DJ, Chen C, Penaloza DA. Pain as a factor complicating recovery and discharge after ambulatory surgery. Anesth Analg. 2003;97:1627-32.
Sain AH. Laparoscopic cholecystectomy is the current “gold standard” for the treatment of gallstone disease. Annals of Surgery. 1996;224(5):689-90.
Aitola P, Airo I, Kaukinen S, Ylitalo P. Comparison of N2O and CO2 pneumoperitoneum during laparoscopic cholecystectomy with special reference to postoperative pain. Surg Laparosc Endosc. 1998;8:140-4.
Alexander DJ, Lee L. Randomized trial of periportal peritoneal bupivacaine for pain relief after laproscopic cholecystectomy. Br J Surg. 1996;83(9):1223-5.
Hasaniya N, Zayed F, Faiz H, Severino R. Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy. Surg Endosc. 2001;15:962-64.
Ke RW, Portera SG, Bagous W, Lincoln SR. A randomized, double-blinded trial of preemptive analgesia in laparoscopy. Obstet Gynecol. 1998;92(6):972-5.
Loizides S, Gurusamy KS, Nagendran M, Rossi M, Guerrini GP, Davidson BR. Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy. Cochrane Database of Systematic Reviews. 2014:3. Art. No.: CD007049.
Rafaie AMN, Khatab MM. Reduction of early postoperative pain after diagnostic laparoscopy with local bupivacaine: a randomized placebo controlled study. Middle East Fertil Soc J. 2005;10(3):244-9.
Johnson N, Onwude JL, Player J, Hicks N, Yates A, Bryce F, et al. Pain after laparoscopy: an observational study and a randomized trial of local anesthetic. J Gynecol Surg. 1994;10:129-38.
Saff GN, Marks RA, Kuroda M. Analgesic effect of bupivacaine on extraperitoneal laparoscopic hernia repair. Anesth Analg. 1998;87(2):377-81.
Ure BM, Troidl H, Spangenberger W. Preincisional local anaesthesia with bupivacaine and pain after laparoscopic cholecystectomy. A double-blind randomized clinical trial. Surg Endosc. 1993;7:482-88.
Deans GT, Wilson MS, Brough WA. Controlled trial of preperitoneal local anaesthetic for reducing pain following laparoscopic hernia repair. Br J Surg. 1998;85:1013-4.
Maier C, Broer-Boss F, Kube D, Arp WD. Wound infiltration with bupivacaine following pelviscopy does not reduce postoperative pain intensity. Results of a placebo-controlled, double-blind study. Anaesthesist. 1994;43(8):547-52.
Murrat Sarac A, Baykan N.The effect and timing of local anaesthesia in laparoscopic cholecystectomy. Surg Laparosc Endosc. 1996;6(5):362-6.
Lee IO, Kim SH, Kong MH, Lee MK, Kim NS, Choi YS, et al. Pain after laparoscopic cholecystectomy: the effect and timing of incisional and intraperitoneal bupivacaine. Can J Anaesth. 2001;48(6):545-50.
Uzunkoy A, Coskun A, Akinci OF. The value of pre-emptive analgesia in the treatment of postoperative pain after laparoscopic cholecystectomy. Eur Surg Res. 2001;33(1):39-41.
Maharjan SK, Shrestha S. Intraperitoneal and periportal injection ofbupivacaine for pain after laparoscopic cholecystectomy. Kathmandu Univ Med J (KUMJ). 2009;7(25):50-3.
Bisgaard T, Klarskov B. Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiving prophylactic multi-modal analgesia: a randomized, double-blinded, placebo-controlled study. Anesth Analg. 1999;89(4):1017-24.
Liu YY, Yeh CN, Lee HL, Wang SY, Tsai CY, Lin CC,et al. Local anesthesia with ropivacaine for patients undergoing laparoscopic cholecystectomy. World J Gastroenterol. 2009;15(19):2376-80.
Paulson J, Mellinger J, Baguley W. The use of intraperitoneal bupivacaine to decrease the length of stay in elective laparoscopic cholecystectomy patients. Am Surg. 2003;69(4):275-8.
Pavlidis TE, Atmatzidis KS, Papaziogas BT, Makris JG, Lazaridis CN, Papaziogas TB. The effect of preincisional periportal infiltration with ropivacaine in pain relief after laparoscopic procedures: a prospective, randomized controlled trial. JSLS. 2003;7(4):305-10
Callesen T, Hjort D, Mogensen T, Schouenborg L, Nielsen D, Reventlid H, et al. Combined field block and i.p. instillation of ropivacaine for pain management after laparoscopic sterilization. Br J Anaesth. 1999;82:586-90.
Narchi P, Benhamou D, Bouaziz H, Fernandez H, Mazoit JX. Serum concentrations of local anaesthetics following intraperitoneal administration during laparoscopy. Eur J Clin Pharmacol. 1992;42(2):223-5.