The impact of pre-operative uric acid levels on post-operative renal outcomes in off-pump coronary artery bypass grafting patients

M. Aslam Hossain; Farhat Tabassum Nishat; C. M. Mosabber Rahman; Tania N. Shanta; Mirza M. Nazmus Saquib; M. Abul B. Maruf; Samir K. Yadav

doi:10.18203/2349-2902.isj20242117

Authors

M. Aslam Hossain Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Farhat Tabassum Nishat Department of Trauma and Orthopedics Surgery, West Middlesex University Hospital, United Kingdom
C. M. Mosabber Rahman Department of Cardiac Surgery, Dhaka Medical College Hospital, Dhaka, Bangladesh
Tania N. Shanta Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh
Mirza M. Nazmus Saquib Department of Cardiac Surgery, Ibrahim Cardiac Hospital & Research Institute, Dhaka, Bangladesh
M. Abul B. Maruf Department of Cardiac Surgery, Dhaka Medical College Hospital, Dhaka, Bangladesh;Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh
Samir K. Yadav Manmohan Cardiothaoracic Vascular and Transplant Center, Nepal

DOI:

https://doi.org/10.18203/2349-2902.isj20242117

Keywords:

Coronary artery bypass grafting, Renal outcomes and off-pump, Uric acid level

Abstract

Background: Elevated pre-operative uric acid levels significantly impact post-operative renal outcomes in off-pump CABG patients, increasing the risk of acute kidney injury, as evidenced by higher serum creatinine and reduced urine output.

Methods: This cross-sectional study was conducted in Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, Bangladesh from January 2021 to December 2022. Total 160 patients undergoing off pump CABG were divided into two groups, group A and group B, each containing 80 patients. In group A, uric acid level was <7 mg/dl for male and <6 mg/dl for female and in group B, it was >7 mg/dl and >6 mg/dL for female.

Results: The demographic characteristics, pre-operative serum UA levels and serum creatinine levels between the two groups was not statistically significant. Group A had shorter operative times (mean 265.21±53.33 minutes) compared to Group B (mean 327.04±44.32 minutes), with more patients in Group-B undergoing longer surgeries (>360 minutes). Group-B also had more grafts (mean 4.4 vs 3.6), higher serum creatinine (1.91 vs 1.17 mg/dl), bilirubin (0.8 vs 0.7 mg/dl), and lower urine output (mean 47.52 vs 95.37 ml/hour), all statistically significant (p<0.001).

Conclusions: This study concludes that there is significant impact of pre-operative uric acid levels on post-operative renal outcomes in off-pump CABG patients.

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