Unusual neuroendocrine tumor in unusual site: a case report and review of literature

Jeya Anand Ayyamperumal; Amudhan Anbalagan; Satish Devakumar Murugasen; Selvaraj Thangasamy; Jeswanth Satyanesan

doi:10.18203/2349-2902.isj20242139

Authors

Jeya Anand Ayyamperumal Institute of Surgical Gastroenterology and Liver Transplantation, Stanley Medical College, Chennai, Tamil Nadu, India
Amudhan Anbalagan Institute of Surgical Gastroenterology and Liver Transplantation, Stanley Medical College, Chennai, Tamil Nadu, India
Satish Devakumar Murugasen Institute of Surgical Gastroenterology and Liver Transplantation, Stanley Medical College, Chennai, Tamil Nadu, India
Selvaraj Thangasamy Institute of Surgical Gastroenterology and Liver Transplantation, Stanley Medical College, Chennai, Tamil Nadu, India
Jeswanth Satyanesan Institute of Surgical Gastroenterology and Liver Transplantation, Stanley Medical College, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-2902.isj20242139

Keywords:

Paraganglioma, Peripancreatic, Pancreaticoduodenal groove, Neuroendocrine tumor

Abstract

Paragangliomas (PGL) are uncommon tumors that develop in the extra-adrenal chromaffin cells of the autonomic nervous system. They are usually found in the retroperitoneum along the abdominal para-aortic region. PGL arising near the pancreas are extremely rare. These tumors can be difficult to diagnose as they can resemble more common pancreatic tumors, making it challenging for clinicians, radiologists, and pathologists alike. In this report, we describe a case of PGL that originated in the pancreaticoduodenal groove, which was initially diagnosed as a neuroendocrine tumor arising from the second part of the duodenum. The patient underwent pancreas-preserving surgery to remove the tumour.

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References

Borgohain M, Gogoi G, Das D, Biswas M: Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis. Indian J Endocrine Metabo. 2013;17:917-9.

Gong Y, DeFrias DV, Nayar R. Pitfalls in Fine Needle Aspiration Cytology of Extraadrenal Paraganglioma: A Report of 2 cases. Acta Cytologica. 2003;47:1082-6.

Inzani F, Rindi G, Tamborrino E, Cobelli R, Bordi C. Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass. Endocrine Pathol. 2009;20:191-5.

Tsukada A, Ishizaki Y, Nobukawa B, Kawasaki S. Paraganglioma of the pancreas: a case report and review of the literature. Pancreas. 2008;36:214-6.

Singhi AD, Hruban RH, Fabre M, Imura J, Schulick R, Wolfgang C, et al. Peripancreatic Paraganglioma: A Potential Diagnostic Challenge in Cytopathology and Surgical Pathology. Am J Surg Pathol. 2011;35:1498-504.

Bello HR, Sekhar A, Ross W. Filice, Radmard AR, Davarpanah AH. Pancreaticoduodenal Groove: Spectrum of Disease and Imaging Features. RadioGraphics. 2022;42:1062-80.

Shah S, Mortele KJ. Semin: Uncommon Solid Pancreatic Neoplasms: Ultrasound, Computed Tomography, and Magnetic Resonance Imaging features. Semin Ultrasound CT MRI. 2007;28:357-70.

Elsayes KM, Narra VR, Leyendecker JR, Francis IR, Lewis JS Jr, Brown JJ. MRI of adrenal and extraadrenal pheochromocytoma. Am J Roentgenol. 2005;2005:860-7.

Raman SP, Hruban RH, Cameron JL, Wolfgang CL, Fishman EK. Pancreatic Imaging Mimics: Part 2, Pancreatic Neuroendocrine Tumors and their Mimics. Am J Roentgenol. 2012;199:309-18.

Renshaw AA, Lee KR, Madge R. Accuracy of Fine Needle Aspiration in Distinguishing subtypes of Renal Cell Carcinoma. Acta Cytologica. 1997;41:987-94.

Lanke G, Stewart JM, Lee JH. Pancreatic paraganglioma diagnosed by endoscopic ultrasound-guided fine needle aspiration: A case report and review of literature. World J Gastroenterol. 2021;27:6322-31.

Fliedner SM, Lehnert H, Pacak K. Metastatic paraganglioma. Semin Oncol. 2010;37:627-37.

Burnichon N, Rohmer V, Amar L, Herman P, Leboulleux S, Darrouzet V, et al. The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas. J Clin Endocrinol Metab. 2009;94(8):2817-27.

Ginesu GC, Barmina M, Paliogiannis P, Trombetta M, Cossu ML, Feo CF, et al. Nonfunctional paraganglioma of the head of the pancreas: A rare case report. Int J Surg Case Rep. 2016;28:81-4.

Liew SH, Leong AS, Tang HM. Tracheal paraganglioma: a case report with review of the literature. Cancer. 1981;47:1387-93.

Ginesu GC, Puledda M, Feo CF, Cossu ML, Fancellu A, Addis F, et al. Abdominal wall schwannoma. Gastrointest Surg. 2016;20(10):1781-3.

Manning MA, Paal EE, Srivastava A, Mortele KJ. Radiographics: Nonepithelial neoplasms of the pancreas, part 2: malignant tumors and tumors of uncertain malignant potential from the radiologic pathology archives. Radiographics. 2018;38:1047-72.

Meng L, Wang J, Fang SH. Primary pancreatic paraganglioma: A report of two cases and literature review. World J Gastroenterol. 2015;21:1036-9.

Jiang CN, Cheng X, Shan J, Yang M, Xiao YQ. Primary pancreatic paraganglioma harboring lymph node metastasis: A case report. World J Clin Cases. 2021;9(27):8071-81.