Uterine fibroids: a review
DOI:
https://doi.org/10.18203/2349-2902.isj20241288Keywords:
Uterine myomatosis, Fibroma, Hysterectomy, Hysteroscopy, Myoma, LeiomyomaAbstract
Myomatosis of large elements are benign tumors resulting from the growth of muscular and fibrous tissue, which can be embedded or adhered to the uterine wall and their classification varies between submucosal, intramural or subserous depending on the depth they reach. More frequently, symptomatic patients report the presence of abundant abnormal uterine bleeding, dysmenorrhea, dyspareunia and infertility. This pathology represents 40-60% of all hysterectomies, of the total, 30% in women of childbearing age. Different possible triggers of uterine fibroids have been described, which is why it is considered to be of multifactorial origin. Ultrasound is usually used frequently due to its high availability and low cost, this being the first diagnostic image of choice and the gold standard, through transvaginal ultrasound. The management of myomastomas entails a great social problem, since therapy seeks treatment methods that prevent the recurrence of the disease, and in case of satisfied parity, hysterectomy is the ideal option, but in those patients still of fertile age and with desire of pregnancy, less drastic procedures such as myomectomy will be carried out. Finally, some post-surgical complications have been discussed, among which the generation of adhesions due to the scarring resulting from the surgical intervention was described, which could generate infertility or greater difficulty in conceiving.
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References
Rosales Costa K, Bastos Metzger P. Endovascular treatment of uterine myomatosis: a systematic review. J Vasc Bras. 2020;19:e20190149.
Medina-Bastidas D, Camacho-Arroyo I, García-Gómez E. Current findings in endometrial microbiome: impact on uterine diseases. Reproduction. 2022;163:R81-96.
Onishi K, Zhang, Blanck JF. A systematic review of matrix metalloproteinases as potential biomarkers for uterine fibroids. Fertil Steril Rev. 2022;3(4):2666-5719.
Medikare V, Kandukuri LR, Ananthapur V, Deenadayal M, Nallari P. The genetic bases of uterine fibroids; a review. J Reprod Infertil. 2011;12(3):181-91.
Campione E, Di Prete M, Costanza G, Saggini A, Agostinelli S, Terrinoni A, et al. Increased Occurrence of Cutaneous Leiomyomas and Dermatofibromas in Patients with Uterine Leiomyomas without Fumarate Hydratase Gene Mutations. Dermatopathology. 2023;10:231-43.
Kuznetsova MV, Tonoyan NM, Trubnikova EV, Zelensky DV, Svirepova KA, Adamyan LV, et al. Novel Approaches to Possible Targeted Therapies and Prophylaxis of Uterine Fibroids. Diseases. 2023;11:156.
Shi S, Luo L, Peng F, Yu C. Potential mechanism of Taohong Siwu Decoction in uterine fbroid treatment based on integrated strategy of network pharmacology and experimental verifcation. Chinese Med. 2023;18:95.
Hernández-Valencia M, Valerio-Castro E, Tercero-Valdez-Zúñiga CL, Barrón-Vallejo J, Luna-Rojas RM. Uterine myomatosis: Implications on reproductive health. Gynecol Obstet Méx. 2017;85(9):611-33.
Lethaby A, Vollenhoven B. Fibroids uterine myomatosis, leiomyomas. BMJ Clin Evid. 2007;08:14.
Torres de la Roche LA, Becker S, Cezar C, Hermann H, Larbig A, Leicher L. Pathobiology of myomatosis uteri: the underlying knowledge to support our clinical practice. Arch Gynecol Obstet. 2017;296:701-7.
Montiel-Jarquín AJ, García-Ramírez UN, Morales-Castillo JC, Bobadilla-Valenzuela R, Mendoza-García AV, López-Hernández A. Leiomiomatosis uterina de grandes elementos en una paciente joven. Revista Médica del Instituto Mexicano del Seguro Social. 2008;46(6):677-80.
Sparic R, Mirkovic L, Malvasi A, Tinelli A. Epidemiology of Uterine Myomas: A Review. Int J Fertil Steril. 2016;9(4):424-35.
Zimmermann A, Bernuit D, Gerlinger C, Schaefers M, Geppert K. Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women. BMC Womens Health. 2012;26;12:6.
Etrusco A, Buzzaccarini G, Laganà AS, Chiantera V, Vitale SG, Angioni S. Use of Diode Laser in Hysteroscopy for the Management of Intrauterine Pathology: A Systematic Review. Diagnostics. 2024;14:327.
Tokarz J, Adamski J, Tea Rižner TL. Metabolomics for Diagnosis and Prognosis of Uterine Diseases? A Systematic Review. J Pers Med. 2020;10:294.
Donnez J, Dolmans MM. Uterine fibroid management: from the present to the future. Hum Reprod Update. 2016;22(6):665-86.
Sun S, Bonaffini P, Nougaret S, Fournier L, Dohan A, Chong J, et al. How to differentiate uterine leiomyosarcoma from leiomyoma with imaging. Diagnost Intervent Imaging. 2019;100(10):619-34.
Palheta MS, Medeiros FDC, Severiano ARG. Reporting of uterine fibroids on ultrasound examinations: an illustrated report template focused on surgical planning. Radiol Bras. 2023;56(2):86-94.
Wilde S, Scott-Barrett S. Radiological appearances of uterine fibroids. Indian J Radiol Imaging. 2009;19(3):222-31.
Morales HSG, López RR, López GGP, Mondragón PJC, Cortés DV, Hernández HS, et al. Surgical approach to uterine myomatosis in patients with infertility: open, laparoscopic, and robotic surgery; results according to the quantity of fibroids. JBRA Assist Reprod. 2022;26(1):44-9.
De La Cruz M Syl D, Buchanan EM. Uterine Fibroids: Diagnosis and Treatment. Am Fam Physician. 2017;95(2):100-7.
Gao M, Bhosale P, Devine C, Palmquist S, Javadi S. US, MRI, CT Performance and Interpretation of Uterine Masses. Seminars in Ultrasound, CT and MRI. 2023;44(6):541-59.
Fábregues F, Peñarrubia J. Mioma uterino. Manifestaciones clínicas y posibilidades actuales de tratamiento conservador. Med Integral. 2002;40(5):190-5.
