Primary spinal glioblastoma multiforme: a case report

Authors

  • Aaqid Siraj Syed Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India https://orcid.org/0009-0009-9128-1023
  • Sanjana Sehgal Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India
  • Sanjeev K. Pandey Department of Neurosurgery, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Brijesh K. Tiwari Department of Neurosurgery, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Ranjit Kumar Department of Neurosurgery, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Meenu Gupta Department of Radiotherapy, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India

DOI:

https://doi.org/10.18203/2349-2902.isj20241410

Keywords:

Spinal cord, Glioblastoma, Temozolomide, RT, Surgery

Abstract

Spinal cord glioblastoma multiforme (GBM) is an uncommon disease within spinal tumours. According to our review of literature, less than 200 patients have been reported so far. Here we highlight the case of a 35 year female who complained of mild and intermittent lower back pain that radiates to bilateral thighs and was associated with tingling and numbness over both feet. The patient was evaluated and operated elsewhere with L1-L2 laminectomy and micro-surgical excision and it was reported as a case of myxopapillary ependymoma. However, immunohistochemical (IHC) stains were positive for GBM grade IV. A residual tumour was seen in postoperative magnetic resonance imaging (MRI) at our institute. Subsequently, the patient was subjected to adjuvant radiotherapy (RT) and regular Temozolomide chemotherapy following near-total resection of the mass. Aggressive management of this condition with timely chemo radiation is needed to enhance survival and assure a decent quality of life.

References

Mori K, Imai S, Shimizu J, Taga T, Ishida M, Matsusue Y. Spinal glioblastoma multiforme of the conus medullaris with holocordal and intracranial spread in a child: a case report and review of the literature. Spine J. 2022;12(1):e1-6.

Balériaux DL. Spinal cord tumors. Eur Radiol. 1999;9(7):1252-8.

Cacchione A, Mastronuzzi A, Cefalo MG, Colafati GS, Diomedi-Camassei F, Rizzi M, et al. Pediatric spinal glioblastoma of the conus medullaris: a case report of long survival. Chin J Cancer. 2016;35(1):44.

Shen C-X, Wu J-F, Zhao W, Cai Z-W, Cai R-Z, Chen C-M. Primary spinal glioblastoma multiforme: A case report and review of the literature. Medicine (Baltimore). 2017;96(16):e6634.

Koeller KK, Rosenblum RS, Morrison AL. Neoplasms of the spinal cord and filum terminale: radiologic-pathologic correlation. Radiographics. 2000;20(6):1721-49.

Farzin M, Hajiabadi M, Rahmani M, Kolahdouzan K. Mixed malignant glioblastoma and schwannoma in spinal cord with metachronous ependymoma: A case report. Clin Case Rep. 2021;9(6):e04162.

Kotecha R, Mehta MP, Chang EL, Brown PD, Suh JH, Lo SS, et al. Updates in the management of intradural spinal cord tumors: a radiation oncology focus. Neuro Oncol. 2019;21(6):707-18.

Ononiwu C, Mehta V, Bettegowda C, Jallo G. Pediatric spinal glioblastoma multiforme: current treatment strategies and possible predictors of survival. Childs Nerv Syst. 2012;28(5):715-20.

Konar SK, Maiti TK, Bir SC, Kalakoti P, Bollam P, Nanda A. Predictive factors determining the overall outcome of primary spinal glioblastoma multiforme: An integrative survival analysis. World Neurosurg. 2016;86:341-8.e1-3.

Behmanesh B, Setzer M, Konczalla J, Harter P, Quick-Weller J, Imoehl L, et al. Management of patients with primary intramedullary spinal cord glioblastoma. World Neurosurg. 2017;98:198-202.

Bonde V, Balasubramaniam S, Goel A. Glioblastoma multiforme of the conus medullaris with holocordal spread. J Clin Neurosci. 2008;15(5):601-3.

Kim WH, Yoon SH, Kim C-Y, Kim K-J, Lee MM, Choe G, et al. Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review. J Neurooncol. 2011;101(2):247-54.

Jagtap V, Shashank B. Spinal glioblastoma multiforme with brain and spinal seeding: treatment approach from various view points | Int J Curr Res. 20179(5):50025-8.

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-96.

Chaurasia A, Park S-H, Seo J-W, Park C-K. Immunohistochemical analysis of ATRX, IDH1 and p53 in glioblastoma and their correlations with patient survival. J Korean Med Sci. 2016;31(8):1208-14.

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 2016;131(6):803-20.

Young RM, Jamshidi A, Davis G, Sherman JH. Current trends in the surgical management and treatment of adult glioblastoma. Ann Transl Med. 2015;3(9):121.

Mayer RR, Warmouth GM, Troxell M, Adesina AM, Kass JS. Glioblastoma multiforme of the conus medullaris in a 28-year-old female: a case report and review of the literature. Clin Neurol Neurosurg. 2012;114(3):275-7.

Kaley TJ, Mondesire-Crump I, Gavrilovic IT. Temozolomide or bevacizumab for spinal cord high-grade gliomas. J Neurooncol. 2012;109(2):385-9.

Strik HM, Effenberger O, Schäfer O, Risch U, Wickboldt J, Meyermann R. J Neurooncol. 2000;50(3):239-43.

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Published

2024-05-29

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Section

Case Reports