Asymptomatic marginal zone lymphoma detected on routine mammogram, an unusual presentation


  • Ryan J. Green Department of Surgery, Cairns Base Hospital, Queensland, Australia
  • Sarath Vennam Department of Radiology, Royal Cornwall Hospital, UK
  • Max Ireland Department of Radiology, University Hospital Plymouth, UK
  • Grant Withey Department of Radiology, Townsville University Hospital, Queensland, Australia
  • Amelia Melloy Department of Surgery, Cairns Base Hospital, Queensland, Australia



MZI, Mammogram, Incidental finding, Breast cancer


A patient in her 60 years presented for routine mammographic screening. A lesion was identified, which on biopsy was proven to be marginal zone lymphoma (MZL). MZL is a group of indolent non-Hodgkin’s B-Cell lymphomas. Involvement of breast tissue is rare and can mimic more common breast pathology. In addition, the patient had widespread subcutaneous lesions which is also atypical of the cutaneous form of MZL lymphoma. This case describes the multi-modality radiological findings of this uncommon presentation of diffuse cutaneous MZL.



Cheah CY, Zucca E, Rossi D, Habermann TM. Marginal zone lymphoma: present status and future perspectives. Haematologica. 2022;107(1):35.

Merli M, Arcaini L. Management of marginal zone lymphoma. Hematology Am Soc Hematol Educ Program. 2022;2022(1):676-87.

Sriskandarajah P, Dearden CE. Epidemiology and environmental aspects of marginal zone lymphomas. Best Pract Res Clin Haematol. 2017;30(1-2):84-91.

Cerhan JR, Habermann TM. Epidemiology of Marginal Zone Lymphoma. Ann Lymphoma. 2021;5:1-1.

Olszewski AJ, Castillo JJ. Survival of patients with marginal zone lymphoma: analysis of the Surveillance, Epidemiology, and End Results database. Cancer. 2013;119(3):629-38.

Kolb TM, Lichy J, Newhouse JH. Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. Radiology. 2002;225(1):165-75.

Moura C, Leite MI, Parreira R, Medeiros A. Primary breast lymphoma. J Surg Case Rep. 2020;2020(1).

Reeves RA, Kaufman T. Mammography. Medical Imaging: Principles and Practices. Treasure Island (FL): StatPearls Publishing. 2024;1-22.

Saadatmand S, Geuzinge HA, Rutgers EJT, Mann RM, de Roy van Zuidewijn DBW, Zonderland HM, et al. MRI versus mammography for breast cancer screening in women with familial risk (FaMRIsc): a multicentre, randomised, controlled trial. Lancet Oncol. 2019;20(8):1136-47.

Horvath E, Silva C, Fasce G, Ferrari C, Pinochet MA, Galleguillos C, et al. Parallel Artery and Vein: Sign of Benign Nature of Breast Masses. AJR Am J Roentgenol. 2012;198(1):W76-82.






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