Impact of microporous polysaccharide haemostatic agent on patients undergoing mastectomy or axillary dissection on seroma formation and timing of drain removal

Sarah Mahmood; Alen Maximillian Brodaric; Rajkumar Srinivasan; Ruben Cohen-Hallaleh

doi:10.18203/2349-2902.isj20240674

Authors

Sarah Mahmood Department of General Surgery, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia
Alen Maximillian Brodaric Department of Surgery, Tamworth Rural Referral Hospital, North Tamworth, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia
Rajkumar Srinivasan Department of Surgery, Tamworth Rural Referral Hospital, North Tamworth, NSW, Australia
Ruben Cohen-Hallaleh Department of General Surgery, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia

DOI:

https://doi.org/10.18203/2349-2902.isj20240674

Keywords:

Breast seroma, Mastectomy, ARISTA, ALND

Abstract

Background: Seroma formation is a known complication following mastectomy and axillary lymph node dissection (ALND) leading to morbidity and financial implications for patients. ARISTA^TM AH has been designed to prevent postoperative seromas formation in vitro.

Methods: We performed a single institution, single surgeon retrospective study from January 2017 to December 2022 in patients undergoing mastectomy/axillary dissection to evaluate seroma formation rates and timing of drain removal.

Results: A total of 72 cases were included in our retrospective review of electronic medical records. Of these, 40 patients underwent ipsilateral mastectomies with sentinel node biopsies, 8 patients underwent bilateral mastectomies, and 18 patients underwent axillary dissections without concurrent mastectomy. Our analysis showed a non-significant decrease in seroma formation when ARISTA^TM AH was used intra-operatively (10%) compared to standard care (24%), (p=0.14). The ARISTA^TM AH group had a statistically significantly longer mean drain removal time than the standard care group (12.9 vs 7.6 days, p=0.002).

Conclusions: There was a trend towards lower seroma formation and a significantly longer requirement for drain placement after mastectomy in ARISTA^TM AH group. Further research including randomised controlled multi-centre study evaluating the benefit of topical haemostatic agents in reducing seroma formation in breast surgery is warranted.

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