Thyroxine replacement by colonic route and absorption kinetics: case report

Ricardo-Raziel Peña-González; Jonathan Quiroz-Alvarez; Jocelyn Sánchez-Paredes; Juan-Carlos  Juárez-Vanegas; Daniel-Eduardo Aguilera-Callejas; Antonio Segovia; Agustín Etchegaray-Dondé; Francisco Higuera-Hidalgo

doi:10.18203/2349-2902.isj20240004

Authors

Ricardo-Raziel Peña-González Department of General Surgery, Hospital General de México, Mexico City, Mexico
Jonathan Quiroz-Alvarez Department of General Surgery, Hospital General de México, Mexico City, Mexico
Jocelyn Sánchez-Paredes Department of General Surgery, Hospital General de México, Mexico City, Mexico
Juan-Carlos Juárez-Vanegas Department of General Surgery, Hospital General de México, Mexico City, Mexico
Daniel-Eduardo Aguilera-Callejas Department of General Surgery, Hospital General de México, Mexico City, Mexico
Antonio Segovia Department of Endocrinology, Hospital General de México, Mexico City, Mexico
Agustín Etchegaray-Dondé Department of General Surgery, Hospital General de México, Mexico City, Mexico
Francisco Higuera-Hidalgo Department of General Surgery, Hospital General de México, Mexico City, Mexico

DOI:

https://doi.org/10.18203/2349-2902.isj20240004

Keywords:

Enema, Hypothyroidism, Thyroxine

Abstract

In the literature there are only 2 reports of replacement of thyroid hormones by colonic route. The objective of this study is to present a clinical case where thyroid hormone replacement was performed through the application of enemas with levothyroxine. 78-year-old patient with hypothyroidism is presented who attended to the emergency room with intestinal occlusion, which presented refractory hypothyroidism secondary to intestinal occlusion and she underwent hormone replacement with enemas with levothyroxine. The kinetics of colonic absorption of thyroid hormones takes twice as long to reach the plateau of serum levels with respect to absorption in jejunum and ileum.

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